IMR Press / FBL / Volume 25 / Issue 3 / DOI: 10.2741/4811

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Extra-cellular vesicles carry proteome of cancer hallmarks
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1 Computational and Experimental Biology Group, CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ciencias Medicas, Universidade NOVA de Lisboa, Campo dos Martires da Patria, 130, 1169-056 Lisboa, Portugal
2 Systems Oncology Group, Champalimaud Research, Champalimaud Centre for the Unknown, Av. Brasilia, Doca de Pedroucos, 1400-038 Lisbon, Portugal
3 Centre for Clinical Proteomics, Dept of Clinical Biochemistry and Pharmacology, Odense University Hospital, Sdr. Boulevard 29, DK-5000 Odense C
4 ITAV-IPBS-UPS CNRS USR3505, 1 place Pierre Potier, Oncopole entree B, 31106 Toulouse, France
5 Center for Molecular Medicine, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore 560029, India
6 Manipal Academy of Higher Education (MAHE), Manipal 576104, Karnataka, India
7 Institute of Bioinformatics, Discoverer building, ITPL, Bangalore 560066, India
8 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester 55905, MN, USA
Front. Biosci. (Landmark Ed) 2020, 25(3), 398–436; https://doi.org/10.2741/4811
Published: 1 January 2020
(This article belongs to the Special Issue Elucidation of exosomes role in metastasis)
Abstract

Through lateral transfer, extra-cellular vesicles (EVs) transport their DNA, miRNA, mRNA and proteins such as enzymes mediating drug resistance, transporters as well as growth factors to neighboring cells. By virtue of this horizontal transfer, EVs potentially regulate cell growth, migration, angiogenesis and metastasis and increase tissue permeability in cancer. Furthermore, EVs regulate immune factors and allow the tumor cells to evade immune recognition and cell death. To explore if the proteomes of exosomes support functional transfer of cancer hallmarks, in this meta-analysis, we compared EVs and whole cell proteomes from the NCI-60 human tumor cell line panel. We observed a subgroup of proteins in each cancer hallmark signature as highly abundant and consistently expressed in EVs from all cell lines. Among these were oncoproteins frequently targeted in cancer therapies whose presence on EVs could potentially render therapies less effective by serving as decoys.

Keywords
Cancer exosomes
Cancer extracellular microvesicles
Proteomics
Biomarkers
Drug resistance
Review
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