IMR Press / FBL / Volume 25 / Issue 11 / DOI: 10.2741/4887

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Curcumin inhibits high glucose oxidative stress and apoptosis in pancreatic beta cells via CHOP/PCG-1α and pERK1/2
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1 Department of Endocrine, Longhu People's Hospital, Shantou, Guangdong, China
2 Department of Emergency Intensive Care Unit(EICU), First Affiliated Hospital of Medical College of Shantou University, Dongxia S Rd, Jinping Qu, Shantou Shi, Guangdong Sheng, China
3 Department of Endocrine, Chao'an District People's Hospital, Chaozhou, Guangdong, China
4 Department of Pharmaceutics, Gomal University, Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan
5 Department of Endocrinology, Shantou Traditional Chinese Medicine Hospital
6 Department of Endocrinology, Zhujiang Hospital Affiliated to Southern Medical University, Guangzhou, Guangdong, China
Front. Biosci. (Landmark Ed) 2020, 25(11), 1974–1984; https://doi.org/10.2741/4887
Published: 1 June 2020
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)
Abstract

Loss of pancreatic beta-cells by apoptosis appears to play an important role in the development of insulin deficiency and the onset and/or progression of the diabetes mellitus. To this end, we report that curcumin prevents high glucose (HG) induced oxidative stress and apoptosis in mouse pancreatic beta cells. Moreover, curcumin prevents HG induced increase in expression of CHOP, decrease in PCG-1α and phosphorylation of ERK1/2 (pERK1/2) without any effect on the phosphorylation levels of p38 and JNK. Moreover, similar to curcumin, blockade of pERK1/2 reduced the HG induced apoptosis in pancreatic beta cells. Overexpression of CHOP or siRNA knockdown of PCG-1α counteracted the effect of curcumin on HG induced apoptosis and oxidative stress. These results suggest that curcumin acts through CHOP/PCG-1α and ERK1/2 signaling to block the HG induced oxidative stress and apoptosis.

Keywords
Diabetes mellitus; Pancreatic beta cells
Curcumin
Apoptosis; Oxidative stress
CHOP; PGC-1αlpha
MAPK pathway
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