IMR Press / FBL / Volume 24 / Issue 8 / DOI: 10.2741/4792

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Qi-dan-di-huang decoction alleviates diabetic nephropathy by inhibiting the NF-kappaB pathway
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1 School of Traditional Chinese Medicine, Southern Medical University, Guangzhou,510515, Guangdong, China
2 Pharmacy Intravenous Admixture Services, Taian City Central Hospital, Taian, 271000, Shandong, China
3 Department of Cardiology, Taian City Central Hospital, Taian, 271000, Shandong, China
4 Department of Central Laboratory, Taian City Central Hospital, Taian, 271000, Shandong, China
Front. Biosci. (Landmark Ed) 2019, 24(8), 1477–1486; https://doi.org/10.2741/4792
Published: 1 June 2019
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)
Abstract

Diabetic nephropathy (DN) is one of the most serious complications of diabetes mellitus, for which no effective treatment currently exists. We tested the hypothesis that Qi-dan-di-huang (QDDH) might have therapuetic effects in an experimental rat model of DN. The levels of I kappa KinaseAlpha and Beta, p-p65, p-IκB alpha, TGF-β1 and Alpha-SMA were significantly increased in kidneys in DN. QDDH decoction only partially reversed the increased Ikappa KinaseAlpha/Beta, p-p65, p-IKappaB alpha, TGF-Beta1 and alpha-SMA in the kidneys in DN. However, treatment of diabetic rats with QDDH decoction significantly inhibited the production and release of inflammatory cytokines IL-6, IL-1 beta and TNF-alpha into the serum. QDDH decoction also significantly improved the physiologic and biochemical indicators of DN, reduced glycogen and protein deposition in DN and prevented renal fibrosis. Together, the data show that QDDH decoction exerts a protective effect on kidneys in diabetic rats and reverses the inflammatory milieu of the serum in DN.

Keywords
Renal fibrosis
Inflammation
Qi-dan-di-huang decoction
NF-kappaB pathway
Figures
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