IMR Press / FBL / Volume 24 / Issue 8 / DOI: 10.2741/4783

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
MicroRNA-22 regulates thyroid cell growth and lipid accumulation via IL6R
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1 Department of Nephrology, Wenling First People's Hospital of Zhejiang. Wenling, Zhejiang, 317500, People’s Republic of China
*Correspondence: youyao72463@sina.com (Haihong Yan)
Front. Biosci. (Landmark Ed) 2019, 24(8), 1350–1362; https://doi.org/10.2741/4783
Published: 1 June 2019
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)
Abstract

Thyroid stimulating hormone (TSH) is the main regulator of thyroid cell proliferation and endocrine function. Here, we tested the effect of mir-22 in TSH induced proliferation and lipid metabolism of thyroid cells. TSH significantly down-regulated miR-22-3p, promoted proliferation and inhibited apoptosis of thyroid epithelial cells line, FRTL-5; effects that were opposed by overexpression of miR-22-3p. Overexpression of miR-22-3p significantly inhibited TSH- induced expression of lipid metabolic marker genes and increased the expression of lipid catabolism markers and IL6R and led to accumulation of intracellular lipid. IL6R overexpression also led to excessive proliferation, restrained apoptosis and promoted lipid accumulation. In conclusion, miR-22 regulates TSH-induced thyroid cell proliferation and lipid metabolism disorder by impacting IL6R.

Keywords
Thyroid Stimulating Hormone
mir-22
Proliferation
Lipid metabolism
IL-6R
STAT3
HIF-1 alpha
Figures
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