IMR Press / FBL / Volume 24 / Issue 5 / DOI: 10.2741/4759

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
CUEDC2: multifunctional roles in carcinogenesis
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1Department of Gastroenterology, Xiangya Hospital, Central South University, Xiangya Rd, Changsha, Hunan 410008, P. R. China
Front. Biosci. (Landmark Ed) 2019, 24(5), 935–946; https://doi.org/10.2741/4759
Published: 1 March 2019
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)
Abstract
1. ABSTRACT

The ubiquitously expressed multifunctional protein, CUEDC2 (CUE domain-containing 2), is involved in many physiological and pathological processes, including the cell cycle regulation and inflammation. Although it is known that CUEDC2 is expressed disparately in breast cancer, ovarian carcinoma, hepatocellular carcinoma, cholangiocarcinoma, glioma, lung adenocarcinoma, colon cancers, and is involved in the Warburg’s effect, its role in oncogenesis remains to be further explored. In this review, we examine the expression of CUEDC2 in various tumors, and discuss several fundamental signaling pathways that are impacted by CUEDC2.

Keywords
CUEDC2
Tumorigeneses
Cell cycle
Inflammation
Tumor progression
Prognosis
Review
Figures
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