IMR Press / FBL / Volume 24 / Issue 5 / DOI: 10.2741/4755

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Baicalein exerts a protective role in pneumonia caused by Streptococcus pneumoniae
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1 Henan Key Laboratory of Immunology and Targeted Therapy, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang city, Henan Province, China
2 No. 371 Center Hospital of PLA, Xinxiang City, Henan Province, China
Front. Biosci. (Landmark Ed) 2019, 24(5), 849–858; https://doi.org/10.2741/4755
Published: 1 March 2019
(This article belongs to the Special Issue Leader sequences of coronavirus are altered during infection)
Abstract

Streptococcus pneumoniae is the most common pathogenic bacterium of pneumonia and can cause death. Here, we examined the impact of Baicalein on mouse mortality caused by Streptococcus pneumoniae infection. Baicalein protected mice from Streptococcus pneumoniae-induced deaths. Baicalein reduced alveolocapillary membrane permeability, lung infiltration of inflammatory cells, inflammatory cytokine production and pulmonary cell apoptosis. These evidences show that Baicalein is useful in the therapy of a severe form of pneumonia that can cause deaths.

Keywords
Baicalein
Streptococcus pneumoniae pneumonia
Inflammatory cytokines
Inflammatory cells
Figures
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