IMR Press / FBL / Volume 24 / Issue 4 / DOI: 10.2741/4744

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Speckle-interferometry and speckle-correlometry of GB-speckles
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1 Federal Research Center for Virology and Microbiology, Branch in Saratov, Saratov, 410028, Russia
*Correspondence: feodorovav@mail.ru (Valentina A. Feodorova)
Front. Biosci. (Landmark Ed) 2019, 24(4), 700–711; https://doi.org/10.2741/4744
Published: 1 March 2019
(This article belongs to the Special Issue Laser and biological applications)
Abstract

A new method of coding of genetic information using laser speckles has been developed. Specific technique of transforming the nucleotide of gene into a speckle pattern (gene-based speckles or GB-speckles) is suggested. Reference speckle patterns of omp1 gene of typical wild strains of Chlamydia trachomatis of genovars D, E, F, G, and J are generated. This is the first report in which perspectives of the proposed technique in the bacterial gene identification and detection of natural genetic mutations in bacteria as a single nucleotide polymorphism (SNP) are demonstrated. The usage of GB-speckles can be viewed as the next step on the way to the era of digital biology.

Keywords
Chlamydia trachomatis
Genovar
Subtype/typing
Nucleotide sequence
Speckle pattern
Speckle-correlometry
Speckle-interferometry
Figures
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