Ibuprofen as a template molecule for drug design against Ebola virus

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article

Slobodan Paessler¹, Cheng Huang¹, Milan Sencanski², Nevena Veljkovic², Vladimir Perovic², Sanja Glisic², Veljko Veljkovic^3,*

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¹ Department of Pathology, Galveston National Laboratory, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, USA

² Center for Multidisciplinary Research, Institute of Nuclear Sciences Vinca, University of Belgrade, Mihajla Petrovica 12-14, 11001 Belgrade, Serbia

³ Biomed Protection, Galveston, TX, USA

Front. Biosci. (Landmark Ed) 2018, 23(5), 947–953; https://doi.org/10.2741/4627

Published: 1 January 2018

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Abstract

The Ebola virus outbreak in West Africa 2015 and Congo 2017, point out an urgent need for development of drugs against this important pathogen. Previously, by repurposing virtual screening of 6438 drugs from DrugBank, ibuprofen was selected as a possible inhibitor of the Ebola virus infection. The results of an additional docking analysis as well as experimental results showing measurable anti-Ebola effect of ibuprofen in cell culture suggest ibuprofen as a promising molecular template for the development of drugs for treatment of the infection by Ebola virus.

Keywords

Ebola virus

Ibuprofen

Entry Inhibitors

Glycoprotein

Drug Repositioning

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