Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
The role of T cells in the development of Henoch-Schonlein purpura
1 Department of Pediatrics, the First People Hospital of Changzhou and The Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu Province, China
Abstract
Henoch-Schonlein purpura (HSP) is an IgA-mediated disorder that most commonly occurs in children. Its etiology and pathogenesis remain unknown. In recent years, numerous studies have pointed to a dysfunction of T cells in the pathogenesis of HSP. Here, we will review the epidemiology, clinical and molecular characteristics of HSP, as well as abnormalities of Th cell subsets in this disorder. Finally, we will discuss the key factors that are involved in Th cell differentiation as potential novel targets for the prevention and treatment of HSP.
Keywords
- Henoch-Schonlein purpura
- CD4+ T cells
- Differentiation
- Cytokines
- Transcription Factors
- Review