IMR Press / FBL / Volume 23 / Issue 2 / DOI: 10.2741/4593

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Growth factors in the pathogenesis of diabetic foot ulcers

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1 Department of Plastic Surgery, Xiangya Hospital, Central South University, Changsha, China
2 Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, China
3 Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China
4 Institute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, China
Front. Biosci. (Landmark Ed) 2018, 23(2), 310–317; https://doi.org/10.2741/4593
Published: 1 January 2018
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
Abstract

Foot ulcers affect 15% of patients with diabetes, resulting in a great health burden. The occurrence and development of diabetic foot ulcers is associated with neuropathy, peripheral arterial disease, and infection. Several growth factors are involved in these processes, including epidermal growth factor, vascular endothelial growth factor, transforming growth factor-beta, fibroblast growth factor, and erythropoietin, which could promote wound healing of patients with diabetes. Thus, this review discusses the role of these growth factors in the pathogenesis of diabetic foot ulcers, aiming to achieve novel insights into the management of diabetic foot ulcers.

Keywords
Growth factors
Epidermal Growth Factor
Diabetic Foot Ulcers
Review
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