IMR Press / FBL / Volume 23 / Issue 12 / DOI: 10.2741/4705

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Thyroid cancer phenotypes in relation to inflammation and autoimmunity

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1 Endocrinology, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy
2 Division of General Medicine, S. Giuseppe Hospital, Istituto Auxologico Italiano, Piancavallo (VB), Italy
3 Department of Health Sciences, University of Piemonte Orientale, Novara, Italy
Front. Biosci. (Landmark Ed) 2018, 23(12), 2267–2282; https://doi.org/10.2741/4705
Published: 1 June 2018
(This article belongs to the Special Issue Digging deep into thyroid pathophysiology)
Abstract

Thyroid cancer represents the most frequent endocrine neoplasm and is epidemiologically linked to a growing incidence worldwide, which is only in part explained by the increased detection of small cancers in a preclinical stage. Understanding the molecular pathogenesis of well-differentiated thyroid cancers and poorly-differentiated thyroid cancers has prompted interest into the identification of crucial signaling pathways and molecular derangements related to genetic and epigenetic alterations. Increasing attention has been recently focused on inflammation and immunity as major culprit mechanisms involved in thyroid tumourigenesis, through the detection of activated immune cells, pro-inflammatory cytokines, as well as signal integrations between inflammatory and proliferative pathways within the thyroid tumour micro-environment. In addition to playing important roles in tumour surveillance and rejection, the presence of tumour-associated macrophages and the activation of NF-κB signaling pathway are now reckoned as hallmarks and crucial mediator of inflammation-induced growth and progression of thyroid cancer. Thorough understanding of this immunological link and identification of novel molecular targets could provide unprecedented opportunities for research and development of diagnostic, prognostic and treatment strategies for thyroid cancer.

Keywords
Thyroid Cancer
Inflammation
Autoimmunity
Review
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