IMR Press / FBL / Volume 23 / Issue 10 / DOI: 10.2741/4681

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Maternal deprivation promotes hippocampal neuronal apoptosis via ERK1/2 signaling

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1 Department of Admission and Employment, Qiqihar Medical University, Qiqihar, China
2 Xiang Ya Nursing School , Central South University, Changsha, China
3 School of Nursing, Qiqihar Medical University, Qiqihar, China
Front. Biosci. (Landmark Ed) 2018, 23(10), 1923–1932;
Published: 1 June 2018
(This article belongs to the Special Issue Cellular immunology and stem cell biology)

Neonatal maternal deprivation (MD) leads to depressive-like behaviors by promoting hippocampal neuronal apoptosis, but whether and how ERK1/2 signaling participates in MD-induced hippocampal neuronal apoptosis remains unclear. We therefore explored the role of ERK1/2 signaling pathway in neonatal MD-induced depression. Neonatal rats were divided into control group, PD group given intraperitoneal injections of MAPKK inhibitor (PD98059), MD group, and MD+PD group. The neonatal MD model was confirmed by behavioral tests. Compared with controls, MD group showed increased hippocampal neuronal apoptosis, higher mRNA expressions of Bax, caspase-3 and caspase-9mRNAs, and lower expression of Bcl-2 and BDNF. Similarly, compared with controls, MD group showed higher protein expression and wider distribution of Bax, caspase-3, caspase-9 and Cytochrome C but lower protein expression of Bcl-2, p-CREB, BDNF and p-ERK1/2. The changes in the MD group were reversed in the MD+PD group, except that p-ERK1/2 expression was decreased. In conclusion, MD-induced depression is associated with hippocampal neuronal apoptosis, which may be mediated by the ERK1/2 signaling pathway. These findings may provide novel avenues for depression therapy.

Neonatal maternal Deprivation
Signaling Pathway
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