IMR Press / FBL / Volume 22 / Issue 7 / DOI: 10.2741/4537

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Danshen extract regulates the expression of aquaporin 3 in human amniotic epithelial cells

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1 Department of Obstetrics and Gynecology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou 325027, China

Academic Editor: Wei Qin

Front. Biosci. (Landmark Ed) 2017, 22(7), 1138–1147; https://doi.org/10.2741/4537
Published: 1 March 2017
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
Abstract

Danshen extract has been used in the treatment of oligohydramnios, however, the mechanism of its action has not been elucidated. Previously, we demonstrated that down-regulation of AQP3 in fetal membranes may contribute to the development of oligohydramnios. In this study, we investigated the effects of Danshen extract on AQP3 expression in human amniotic epithelial cells from term pregnancies with oligohydramnios or those with those with (those with) normovolemic amniotic fluid. Human amniotic epithelial cells from the oligohydramnios group expressed a lower level of AQP3 mRNA and protein than those with normovolemia. Tweleve hour (Twelvehours) of treatment with Danshen extract, in a dose dependent manner, significantly increased the expression of AQP3 in the two groups. However, human amniotic epithelial cells from the oligohydramnios patients showed a greater sensitivity to the treatment of Danshen extract. These data provide a molecular basis for the treatment of patients with oligohydraminos.

Keywords
Aquaporin 3
oligohydramnios
amniotic epithelial cells
Danshen
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