IMR Press / FBL / Volume 22 / Issue 3 / DOI: 10.2741/4499

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Advances in the treatment of rotator cuff lesions by cytokines

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1 Department of Orthopedics, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine, ZhabeiArea, Shanghai 200072, China
2 Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China

Academic Editor: Fei He

Front. Biosci. (Landmark Ed) 2017, 22(3), 516–529; https://doi.org/10.2741/4499
Published: 1 January 2017
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
Abstract

Rotator cuff tear is one of the most common shoulder injuries, often requiring surgical intervention, including options such as suture repair, autografts, allografts, and synthetic prostheses. While surgery can significantly improve outcomes, an ideal therapeutic strategy has not been found. Often, injuries respond poorly and require prolonged rehabilitation. Recent attention has been focused on biologic pathways which can augment tendon healing, consequently leading to the identification of growth factors. Herein, we review growth factors and their roles in rotator cuff healing.

Keywords
Rotator Cuff Lesion
Cytokines
Rotator Cuff Healing
TGF-beta
Review
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