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Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

1 Jan 2017Review

Multiplex immunoassays in endometriosis: An array of possibilities

Dorien F. O 1,2, Yousef El Aalamat 3,4, Etienne Waelkens 5,6, Bart De Moor 3,4, Thomas D’Hooghe 1,2,7, Amelie Fassbender 1,2,*
Affiliations
Article Info

1 KU Leuven, Department of Development and Regeneration, Organ Systems, Leuven, Belgium

2 Department of Obstetrics and Gynaecology, Leuven University Fertility Centre, University Hospital Leuven, Leuven, Belgium

3 Department of Electrical Engineering (ESAT), STADIUS Center for Dynamical Systems, Signal Processing, and Data Analytics, KU Leuven, Kasteelpark Arenberg 10, Box 2446, 3001 Leuven, Belgium

4 iMinds Medical IT, Kasteelpark Arenberg 10, Box 2446, 3001 Leuven, Belgium

5 KU Leuven, Department of Cellular and Molecular Medicine, Campus Gasthuisberg, Leuven, Belgium

6 SyBioMa, Interfaculty Centre for Systems Biology Based Mass Spectrometry, Campus Gasthuisberg, Leuven, Belgium

7 Division of Reproductive Biology, Institute of Primate Research, Karen, Nairobi, Kenya

Abstract

Multiplex immunoassays range from small-scaled multiplex sandwich ELISAs in a planar or bead-based format to the more expanded antibody arrays employing direct sample labeling. The plethora of data generated from these arrays could be of great interest to understand a complex disorder such as endometriosis. Multiplex immunoassay analysis may provide information on disease pathology and may lead to improved, timely diagnosis. Until now, the use of multiplex immunoassays has been limited in endometriosis. With the constant development of multiplex technologies, future studies should focus on implementing these techniques, and combining them with multivariate statistical analysis. In this review, we provide an overview of multiplex immunoassay methods used in endometriosis studies and the data sets acquired by these methodologies. These data and future studies might provide novel insights for biomarker discovery and investigation of the pathogenesis in endometriosis.

Keywords

  • Endometriosis
  • Multiplex Immunoassay
  • Planar Analytical Sandwich ELISA
  • Bead-based Immunoassay
  • Label-based Antibody Array
  • Biomarker
  • Multivariate Statistics
  • Review

References