IMR Press / FBL / Volume 22 / Issue 3 / DOI: 10.2741/4491

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Drug release kinetics from a drug-eluting stent with asymmetrical coat

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1 Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Niels Jernes Vej 109220 Aalborgo, Denmark
2 Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, 200032 Shanghai, China
3 Shengjing Hospital of China Medical University, 36 Sanhao Street, Heping District, 110004 Shenyang, China
4 Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, No.130, Dongan Road, 200032 Shanghai, China
5 Institute of Chemistry, Chinese Academy of Sciences, Zhongguancun North First Street 2, 100190 Beijing, China
6 Biomedical Research Center, College of Medicine, Qatar University, Shareh AIJamiaa, Postbox 2716, Doha, Qatar

Academic Editor: Fei He

Front. Biosci. (Landmark Ed) 2017, 22(3), 407–415; https://doi.org/10.2741/4491
Published: 1 January 2017
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
Abstract

The aim of this study was to investigate the drug release profiles of biodegradable polymer sirolimus-or paclitaxel-eluting stents with asymmetrical coating (BPSES-A or BPPES-A) both in vitro and in vivo. In vitro, the drug release profile was characterized by measuring the drug concentration by HPLC over a time-course. In vivo, a porcine aorta stenting model was employed. The results showed that the drug release rates of BPSES-A and BPPES-A were slower, more stable and less burst releasing than those of conventionally coated stents (BPSES-C and BPPES-C respectively), both in vitro and in vivo. Based on the in vivo results, the sirolimus and paclitaxel content of the local coronary wall was maintained at a higher and more effective level with BPSES-A and BPPES-A than with BPSES-C and BPPES-C, respectively. The drug levels in peripheral tissue samples were below detection levels. These data demonstrated the effectiveness of both sirolimus and paclitaxel as stent coating agents, and revealed the favorable drug release kinetics and pharmacokinetics of asymmetrical coated stents compared with conventional coated stents.

Keywords
Biodegradable Polymer
Drug-eluting Stent
Drug Release Kinetics
Sirolimus
Paclitaxel
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