IMR Press / FBL / Volume 22 / Issue 2 / DOI: 10.2741/4483

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

New insights into epigenetic modifications in heart failure

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1 Department of Cardiology, Baotou Central Hospital, Baotou, China
2 Department of Surgery, Baotou Central Hospital, Baotou, China
Academic Editor:Fei He
Front. Biosci. (Landmark Ed) 2017, 22(2), 230–247; https://doi.org/10.2741/4483
Published: 1 January 2017
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
Abstract

Heart failure (HF) is a complex syndrome that occurs when the heart is unable to take in and/or eject sufficient blood to meet the needs. HF is generally accompanied by hypertrophic changes of cardiac myocytes, the hallmark of HF. At the molecular level, these changes in cardiomyocyte phenotypes are linked to reprogramming of gene expression. Therefore, understanding the molecular mechanisms involved in these gene expression changes in HF could allow for the development of new therapies for this pathology. One mechanism of gene expression regulation that attracts attention is epigenetic modifications, including DNA methylation, histone methylation and acetylation, microRNA, and long noncoding RNA. In this review, we will discuss diverse functions of these epigenetic modifications in HF, and highlight growing evidence for the important roles of epigenetic changes acting as biomarkers for early diagnosis and prognosis of HF, or even as therapeutic targets in HF.

Keywords
Heart Failure
Cardiac Hypertrophy
DNA Methylation
Histone Methylation
Histone Acetylation
miRNA
lncRNA
Review
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