IMR Press / FBL / Volume 21 / Issue 6 / DOI: 10.2741/4457

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article

Down-regulation and gene hypermethylation of the 14-3-3 gamma in uterine leiomyoma

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1 Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China
Academic Editor:Fei He
Front. Biosci. (Landmark Ed) 2016, 21(6), 1286–1295; https://doi.org/10.2741/4457
Published: 1 June 2016
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
Abstract

We demonstrated that the expression of 14-3-3 gamma was lower in uterine leiomyomas compared to the adjacent normal myometrium. Here, we show that 14-3-3 gamma promoter is methylated more in leiomyomas than myometrium. The level of 14-3-3 gamma protein in leiomyomas did not change in respect to age, size, location, or the type of leiomyoma. ER-alpha, ER-beta, and PR proteins were also higher in leiomyomas and the level of these proteins negatively correlated with the level of 14-3-3 gamma protein. These results suggest that the hypermethylation of the 14-3-3 gene promoter accounts for the decreased 14-3-3 gamma in leiomyomas and that such a low level of expression may be involved in the pathogenesis of leiomyomas.

Keywords
14-3-3 Gamma
Uterine Leiomyoma
Menstrual Cycle
Methylation
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