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Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

1 Jun 2016Review
The function of mechanical loading on chondrogenesis
Zhe Chen 1, Fuhua Yan 1, Yong Lu 1,*
Affiliation
Article Info

1 Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China

Abstract

Articular cartilage is exquisitely sensitive to mechanical loading, one of the most important external factors that regulates its development, integrity and long-term maintenance. Cartilage undergoes degradation by its misuse or overuse. In this review, we elaborate on this role and discuss the application of mechanical stress on chondrocytes and mesenchymal stem cells in order to foster chondrogenesis.

Keywords

  • Articular Cartilage
  • Mechanical Loading
  • Chondrocyte
  • Mesenchymal Stem Cell
  • Chondrogenesis
  • Review

References