IMR Press / FBL / Volume 21 / Issue 6 / DOI: 10.2741/4452

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

The function of mechanical loading on chondrogenesis

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1 Department of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China
Academic Editor:Fei He
Front. Biosci. (Landmark Ed) 2016, 21(6), 1222–1232; https://doi.org/10.2741/4452
Published: 1 June 2016
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
Abstract

Articular cartilage is exquisitely sensitive to mechanical loading, one of the most important external factors that regulates its development, integrity and long-term maintenance. Cartilage undergoes degradation by its misuse or overuse. In this review, we elaborate on this role and discuss the application of mechanical stress on chondrocytes and mesenchymal stem cells in order to foster chondrogenesis.

Keywords
Articular Cartilage
Mechanical Loading
Chondrocyte
Mesenchymal Stem Cell
Chondrogenesis
Review
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