Role of microRNAs in the metastasis of non-small cell lung cancer

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Review

Role of microRNAs in the metastasis of non-small cell lung cancer

Shenglei Li¹, Ming Gao², Zongming Li³, Lijie Song², Xianzheng Gao¹, Jing Han¹, Feng Wang², Yongfang Chen¹, WenCai Li¹, Jianping Yang¹, Xinwei Han^3,*

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¹ Department of Pathology, The First Affliated Hospital of ZhengZhou University, ZhengZhou, 450000, China

² Department of Oncology, The First Affliated Hospital of ZhengZhou University, ZhengZhou, 450000, China

³ Department of Interventional Therapy, The First Affliated Hospital of ZhengZhou University, ZhengZhou, 450000, China

Front. Biosci. (Landmark Ed) 2016, 21(5), 998–1005; https://doi.org/10.2741/4436

Published: 1 June 2016

(This article belongs to the Special Issue Methods for detection of circulating cells in non-small cell lung cancer)

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Abstract

Lung cancer is the leading cause of cancer death. Non-small cell lung cancer (NSCLC), including the squamous cell carcinoma, large cell carcinoma and adenocarcinoma subtypes, accounts for more than 80% of primary lung cancer cases. Understanding the mechanisms underlying NSCLC metastasis is essential for the improvement of anticancer therapies. Recent studies have shown that microRNAs (miRNAs) play very important roles in the progression of NSCLC from its initial stages to metastasis. This review discusses these central roles of miRNAs in the NSCLC metastasis.

Keywords

Non-Small Cell Lung Cancer

MicroRNAs

Metastasis

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