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Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

1 Jun 2016Review

Role of microRNAs in the metastasis of non-small cell lung cancer

Shenglei Li 1, Ming Gao 2, Zongming Li 3, Lijie Song 2, Xianzheng Gao 1, Jing Han 1, Feng Wang 2, Yongfang Chen 1, WenCai Li 1, Jianping Yang 1, Xinwei Han 3,*
Affiliations
Article Info

1 Department of Pathology, The First Affliated Hospital of ZhengZhou University, ZhengZhou, 450000, China

2 Department of Oncology, The First Affliated Hospital of ZhengZhou University, ZhengZhou, 450000, China

3 Department of Interventional Therapy, The First Affliated Hospital of ZhengZhou University, ZhengZhou, 450000, China

Abstract

Lung cancer is the leading cause of cancer death. Non-small cell lung cancer (NSCLC), including the squamous cell carcinoma, large cell carcinoma and adenocarcinoma subtypes, accounts for more than 80% of primary lung cancer cases. Understanding the mechanisms underlying NSCLC metastasis is essential for the improvement of anticancer therapies. Recent studies have shown that microRNAs (miRNAs) play very important roles in the progression of NSCLC from its initial stages to metastasis. This review discusses these central roles of miRNAs in the NSCLC metastasis.

Keywords

  • Non-Small Cell Lung Cancer
  • MicroRNAs
  • Metastasis
  • Review

References