IMR Press / FBL / Volume 21 / Issue 5 / DOI: 10.2741/4435

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Expression and function of peroxiredoxins in gynecological malignancies

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1 Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China
Academic Editor:Wei Qin
Front. Biosci. (Landmark Ed) 2016, 21(5), 986–997; https://doi.org/10.2741/4435
Published: 1 June 2016
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
Abstract

A large family of peroxiredoxin proteins plays essential roles in the regulation of multiple redox-sensitive cellular activities related to cell signaling, cell proliferation and apoptosis. The involvement of these proteins in protecting cells from oxidative damage, induced by reactive oxygen species, points to their potential role in human cancers. According to some studies, the peroxiredoxin proteins in gynecological malignancies, promote tumors development and progression, whereas others indicate that peroxiredoxin proteins function as onco-suppressors in these cancers. Here, we review the utilization of peroxiredoxin proteins as novel biomarkers for screening and early diagnosis of gynecological malignancies, and as the specific therapy targets and prognostic factors as well.

Keywords
Peroxiredoxins
Gynecological Malignancies
Review
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