IMR Press / FBL / Volume 21 / Issue 5 / DOI: 10.2741/4426

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Traumatic brain injury: a review of characteristics, molecular basis and management

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1 Neurosurgical Department, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China
Academic Editor:Wei Qin
Front. Biosci. (Landmark Ed) 2016, 21(5), 890–899;
Published: 1 June 2016
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)

Traumatic brain injury (TBI) is a critical cause of hospitalization, disability, and death worldwide. The global increase in the incidence of TBI poses a significant socioeconomic burden. Guidelines for the management of acute TBI mostly pertain to emergency treatment. Comprehensive gene expression analysis is currently available for several animal models of TBI, along with enhanced understanding of the molecular mechanisms activated during injury and subsequent recovery. The current review focuses on the characteristics, molecular basis and management of TBI.

Traumatic Brain Injury; Excitotoxicity; Intracranial Pressure; Diagnosis and Management
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