Information
References
Contents
Download
[1]A. Hayutin: Global demographic shifts create challenges and opportunities. PREA Quarterly, (Fall), 46-53 (2007)
[2]A. M. Minino: Death in the United States, 2011. NCHS Data Brief (115), 1-8 (2013)
[3]World Health Organization: Description of the global burden of NCDs, their risk factors and determinants. Global status report on noncommunicable diseases 2010 (April), 1-176 (2011)
[4]K. Maiese: SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer. World J Stem Cells, 7(2), 235-42 (2015)
[5]A. Martin, C. A. Tegla, C. D. Cudrici, A. M. Kruszewski, P. Azimzadeh, D. Boodhoo, A. P. Mekala, V. Rus and H. Rus: Role of SIRT1 in autoimmune demyelination and neurodegeneration. Immunol Res, 61 (3), 187-97 (2015)
[6]K. Maiese: Driving neural regeneration through the mammalian target of rapamycin. Neural Regen Res, 9(15), 1413-7 (2014)
[7]K. Maiese: Taking aim at Alzheimer’s disease through the mammalian target of rapamycin. Ann Med, 46(8), 587-596 (2014)
[8]K. Maiese, Z. Z. Chong, J. Hou and Y. C. Shang: New strategies for Alzheimer’s disease and cognitive impairment. Oxid Med Cell Longev, 2(5), 279-89 (2009)
[9]A. Agis-Torres, M. Solhuber, M. Fernandez and J. M. Sanchez-Montero: Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease. Curr Neuropharmacol, 12(1), 2-36 (2014)
[10]C. M. Filley, Y. D. Rollins, C. A. Anderson, D. B. Arciniegas, K. L. Howard, J. R. Murrell, P. J. Boyer, B. K. Kleinschmidt-DeMasters and B. Ghetti: The genetics of very early onset al zheimer disease. Cogn Behav Neurol, 20(3), 149-56 (2007)
[11]Z. Z. Chong, Y. C. Shang, S. Wang and K. Maiese: Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin. Prog Neurobiol, 99(2), 128-148 (2012)
[12]A. K. Mishra, M. S. Ur Rasheed, S. Shukla, M. K. Tripathi, A. Dixit and M. P. Singh: Aberrant Autophagy and Parkinsonism: Does Correction Rescue from Disease Progression? Mol Neurobiol (2014)
[13]K. Maiese: Cutting through the Complexities of mTOR for the Treatment of Stroke. Curr Neurovasc Res, 11 (2), 177-186 (2014)
[14]V. P. Nakka, P. Prakash-Babu and R. Vemuganti: Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries. Mol Neurobiol (2014)
[15]W. Chen, Y. Sun, K. Liu and X. Sun: Autophagy: a double-edged sword for neuronal survival after cerebral ischemia. Neural Regen Res, 9 (12), 1210-6 (2014)
[16]K. Maiese: mTOR: Driving apoptosis and autophagy for neurocardiac complications of diabetes mellitus. World J Diabetes, 6(2), 217-24 (2015)
[17]A. M. Minino and S. L. Murphy: Death in the United States, 2010. NCHS Data Brief (99), 1-8 (2012)
[18]N. Esser, N. Paquot and A. J. Scheen: Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease. Expert Opin Investig Drugs, 24(3), 283-307 (2015)
[19]K. Maiese: New Insights for Oxidative Stress and Diabetes Mellitus. Oxid Med Cell Longev, 2015(Article ID 875961) (2015)
[20]Z. Z. Chong, F. Li and K. Maiese: Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol, 75(3), 207-46 (2005)
[21]G. Harish, A. Mahadevan, N. Pruthi, S. K. Sreenivasamurthy, V. N. Puttamallesh, T. S. Keshava Prasad, S. K. Shankar and M. S. M: Characterization of traumatic brain injury in human brains reveals distinct cellular and molecular changes in contusion and pericontusion. J Neurochem (2015)
[22]J. Lee, X. Gu, L. Wei, Z. Wei, T. A. Dix and S. P. Yu: Therapeutic Effects of Pharmacologically induced Hypothermia against Traumatic Brain Injury in Mice. J Neurotrauma (2014)
[23]K. Maiese: Coma and impaired consciousness. The Merck Manual, 19th Professional Edition (2011)
[24]J. W. Wang, H. D. Wang, Z. X. Cong, X. M. Zhou, J. G. Xu, Y. Jia and Y. Ding: Puerarin ameliorates oxidative stress in a rodent model of traumatic brain injury. J Surg Res, 186(1), 328-37 (2014)
[25]P. R. Kumar, M. M. Essa, S. Al-Adawi, G. Dradekh, M. A. Memon, M. Akbar and T. Manivasagam: Omega-3 Fatty acids could alleviate the risks of traumatic brain injury - a mini review. J Tradit Complement Med, 4(2), 89-92 (2014)
[26]D. C. Costa, N. Alva, L. Trigueros, A. Gamez, T. Carbonell and R. Rama: Intermittent hypobaric hypoxia induces neuroprotection in kainate-induced oxidative stress in rats. J Mol Neurosci, 50(3), 402-10 (2013)
[27]L. Dong, S. Zhou, X. Yang, Q. Chen, Y. He and W. Huang: Magnolol protects against oxidative stress-mediated neural cell damage by modulating mitochondrial dysfunction and PI3K/Akt signaling. J Mol Neurosci, 50(3), 469-81 (2013)
[28]M. B. Gomes and C. A. Negrato: Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases. Diabetol Metab Syndr, 6(1), 80 (2014)
[29]K. Maiese, Z. Z. Chong, J. Hou and Y. C. Shang: Oxidative stress: Biomarkers and novel therapeutic pathways. Exp Gerontol, 45(3), 217-34 (2010)
[30]J. Mehla, M. Pahuja, P. Gupta, S. Dethe, A. Agarwal and Y. K. Gupta: Clitoria ternatea ameliorated the intracerebroventricularly injected streptozotocin induced cognitive impairment in rats: behavioral and biochemical evidence. Psychopharmacology (Berl), 230(4), 589-605 (2013)
[31]M. B. Nejm, A. A. Haidar, M. J. Marques, A. E. Hirata, F. N. Nogueira, E. A. Cavalheiro, F. A. Scorza and R. M. Cysneiros: Fish oil provides protection against the oxidative stress in pilocarpine model of epilepsy. Metab Brain Dis (2015)
[32]D. Radak, I. Resanovic and E. R. Isenovic: Link Between Oxidative Stress and Acute Brain Ischemia. Angiology (2013)
[33]A. Uzdensky, E. Berezhnaya, A. Khaitin, V. Kovaleva, M. Komandirov, M. Neginskaya, M. Rudkovskii and S. Sharifulina: Protection of the Crayfish Mechanoreceptor Neuron and Glial Cells from Photooxidative Injury by Modulators of Diverse Signal Transduction Pathways. Mol Neurobiol (2015)
[34]Y. J. Xin, B. Yuan, B. Yu, Y. Q. Wang, J. J. Wu, W. H. Zhou and Z. Qiu: Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress. Sci Rep, 5, 7645 (2015)
[35]M. Bajda, N. Guzior, M. Ignasik and B. Malawska: Multi-target-directed ligands in Alzheimer’s disease treatment. Curr Med Chem, 18(32), 4949-75 (2011)
[36]Y. Y. Cao, L. Wang, H. Ge, X. L. Lu, Z. Pei, Q. Gu and J. Xu: Salvianolic acid A, a polyphenolic derivative from Salvia miltiorrhiza bunge, as a multifunctional agent for the treatment of Alzheimer’s disease. Mol Divers, 17(3), 515-24 (2013)
[37]V. Exil, L. Ping, Y. Yu, S. Chakraborty, S. W. Caito, K. S. Wells, P. Karki, E. Lee and M. Aschner: Activation of MAPK and FoxO by manganese (Mn) in rat neonatal primary astrocyte cultures. PLoS One, 9(5), e94753 (2014)
[38]P. Grammas, D. Tripathy, A. Sanchez, X. Yin and J. Luo: Brain microvasculature and hypoxia-related proteins in Alzheimer’s disease. Int J Clin Exp Pathol, 4(6), 616-27 (2011)
[39]S. L. Sensi, P. Paoletti, J. Y. Koh, E. Aizenman, A. I. Bush and M. Hershfinkel: The Neurophysiology and Pathology of Brain Zinc. J Neurosci, 31(45), 16076-16085 (2011)
[40]M. M. Aranha, D. M. Santos, S. Sola, C. J. Steer and C. M. Rodrigues: miR-34a regulates mouse neural stem cell differentiation. PLoS One, 6(8), e21396 (2011)
[41]Z. Z. Chong, Y. C. Shang, S. Wang and K. Maiese: SIRT1: New avenues of discovery for disorders of oxidative stress. Expert Opin Ther Targets, 16(2), 167-78 (2012)
[42]W. Duan: Targeting sirtuin-1 in Huntington’s disease: rationale and current status. CNS Drugs, 27(5), 345-52 (2013)
[43]J. Li, L. Feng, Y. Xing, Y. Wang, L. Du, C. Xu, J. Cao, Q. Wang, S. Fan, Q. Liu and F. Fan: Radioprotective and antioxidant effect of resveratrol in hippocampus by activating sirt1. Int J Mol Sci, 15(4), 5928-39 (2014)
[44]D. J. Liu, D. Hammer, D. Komlos, K. Y. Chen, B. L. Firestein and A. Y. Liu: SIRT1 knockdown promotes neural differentiation and attenuates the heat shock response. J Cell Physiol, 229(9), 1224-35 (2014)
[45]S. Saharan, D. J. Jhaveri and P. F. Bartlett: SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus. J Neurosci Res, 91(5), 642-59 (2013)
[46]Q. Sun, N. Jia, W. Wang, H. Jin, J. Xu and H. Hu: Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-beta25-35 in rat cortical neurons. Biochem Biophys Res Commun, 448(1), 89-94 (2014)
[47]S. Wang, Z. Z. Chong, Y. C. Shang and K. Maiese: WISP1 neuroprotection requires FoxO3a post-translational modulation with autoregulatory control of SIRT1. Curr Neurovasc Res, 10(1), 54-60 (2013)
[48]H. Xiong, M. Dai, Y. Ou, J. Pang, H. Yang, Q. Huang, S. Chen, Z. Zhang, Y. Xu, Y. Cai, M. Liang, X. Zhang, L. Lai and Y. Zheng: SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss. Exp Gerontol, 51, 8-14 (2014)
[49]C. Canto, A. A. Sauve and P. Bai: Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. Mol Aspects Med, 34(6), 1168-201 (2013)
[50]Z. Z. Chong, S. H. Lin, F. Li and K. Maiese: The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through Akt, Bad, PARP, and mitochondrial associated “anti-apoptotic” pathways. Curr Neurovasc Res, 2(4), 271-85 (2005)
[51]I. K. Kim, K. J. Lee, S. Rhee, S. B. Seo and J. H. Pak: Protective effects of peroxiredoxin 6 overexpression on amyloid beta-induced apoptosis in PC12 cells. Free Radic Res, 47(10), 836-46 (2013)
[52]S. H. Kwon, S. I. Hong, S. X. Ma, S. Y. Lee and C. G. Jang: 3’,4’,7-trihydroxyflavone prevents apoptotic cell death in neuronal cells from hydrogen peroxide-induced oxidative stress. Food Chem Toxicol (2015)
[53]K. Maiese and Z. Z. Chong: Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain. Trends Pharmacol Sci, 24 (5), 228-32 (2003)
[54]K. Maiese, Z. Z. Chong, J. Hou and Y. C. Shang: The vitamin nicotinamide: translating nutrition into clinical care. Molecules, 14(9), 3446-85 (2009)
[55]L. L. Pan, X. H. Liu, Y. L. Jia, D. Wu, Q. H. Xiong, Q. H. Gong, Y. Wang and Y. Z. Zhu: A novel compound derived from danshensu inhibits apoptosis via upregulation of heme oxygenase-1 expression in SH-SY5Y cells. Biochim Biophys Acta, 1830(4), 2861-71 (2013)
[56]R. Pan, C. Chen, W. L. Liu and K. J. Liu: Zinc promotes the death of hypoxic astrocytes by upregulating hypoxia-induced hypoxia-inducible factor-1alpha expression via poly(ADP-ribose) polymerase-1. CNS Neurosci Ther, 19(7), 511-20 (2013)
[57]C. S. Siegel and L. D. McCullough: NAD+ and nicotinamide: sex differences in cerebral ischemia. Neuroscience, 237, 223-31 (2013)
[58]E. Turunc Bayrakdar, G. Armagan, Y. Uyanikgil, L. Kanit, E. Koylu and A. Yalcin: Ex vivo protective effects of nicotinamide and 3-aminobenzamide on rat synaptosomes treated with Abeta(1-42). Cell Biochem Funct (2014)
[59]E. Turunc Bayrakdar, Y. Uyanikgil, L. Kanit, E. Koylu and A. Yalcin: Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Abeta(1-42)-induced rat model of Alzheimer’s disease. Free Radic Res, 48(2), 146-58 (2014)
[60]T. Chen, L. Zhang, Y. Qu, K. Huo, X. Jiang and Z. Fei: The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med, 29(4), 630-6 (2012)
[61]Z. Z. Chong, J. Kang, F. Li and K. Maiese: mGluRI Targets Microglial Activation and Selectively Prevents Neuronal Cell Engulfment Through Akt and Caspase Dependent Pathways. Curr Neurovasc Res, 2(3), 197-211 (2005)
[62]Z. Z. Chong, F. Li and K. Maiese: GroupI Metabotropic Receptor Neuroprotection Requires Akt and Its Substrates that Govern FOXO3a, Bim, and beta-Catenin During Oxidative Stress. Curr Neurovasc Res, 3(2), 107-17 (2006)
[63]S. Dolan, M. D. Gunn, C. Crossan and A. M. Nolan: Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep. Behav Pharmacol, 22(5-6), 582-8 (2011)
[64]H. Domin, K. Golembiowska, D. Jantas, K. Kaminska, B. Zieba and M. Smialowska: GroupIII mGlu Receptor Agonist, ACPT-I, Exerts Potential Neuroprotective Effects In vitro and In vivo. Neurotox Res (2014)
[65]H. Domin, D. Jantas and M. Smialowska: Neuroprotective effects of the allosteric agonist of metabotropic glutamate receptor 7 AMN082 on oxygen-glucose deprivation-and kainate-induced neuronal cell death. Neurochem Int (2015)
[66]D. Jantas, A. Greda, S. Golda, M. Korostynski, B. Grygier, A. Roman, A. Pilc and W. Lason: Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: the impact of cell differentiation state. Neuropharmacology, 83, 36-53 (2014)
[67]S. H. Lin and K. Maiese: The metabotropic glutamate receptor system protects against ischemic free radical programmed cell death in rat brain endothelial cells. J Cereb Blood Flow Metab, 21(3), 262-75. (2001)
[68]K. Maiese, Z. Z. Chong, Y. C. Shang and J. Hou: Therapeutic promise and principles: Metabotropic glutamate receptors. Oxid Med Cell Longev, 1(1), 1-14 (2008)
[69]K. Maiese, A. Vincent, S. H. Lin and T. Shaw: Group I and Group III metabotropic glutamate receptor subtypes provide enhanced neuroprotection. J Neurosci Res, 62(2), 257-272 (2000)
[70]S. Nasrniya and M. R. Bigdeli: Ischemic tolerance induced by normobaric hyperoxia and evaluation of group I and II metabotropic glutamate receptors. Curr Neurovasc Res, 10(1), 21-8 (2013)
[71]W. Y. Wang, H. Wang, Y. Luo, L. J. Jia, J. N. Zhao, H. H. Zhang, Z. W. Ma, Q. S. Xue and B. W. Yu: The effects of metabotropic glutamate receptor 7 allosteric agonist N,N’-dibenzhydrylethane-1,2-diamine dihydrochloride on developmental sevoflurane neurotoxicity: role of extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase signaling pathway. Neuroscience, 205, 167-77 (2012)
[72]C. J. Williams and D. T. Dexter: Neuroprotective and symptomatic effects of targeting group III mGlu receptors in neurodegenerative disease. J Neurochem, 129(1), 4-20 (2014)
[73]I. Aksu, M. Ates, B. Baykara, M. Kiray, A. R. Sisman, E. Buyuk, B. Baykara, C. Cetinkaya, H. Gumus and N. Uysal: Anxiety correlates to decreased blood and prefrontal cortex IGF-1 levels in streptozotocin induced diabetes. Neurosci Lett, 531(2), 176-81 (2012)
[74]S. Cardoso, R. X. Santos, S. C. Correia, C. Carvalho, M. S. Santos, I. Baldeiras, C. R. Oliveira and P. I. Moreira: Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance. Neurobiol Dis, 49C, 1-12 (2012)
[75]D. Kapogiannis, A. Boxer, J. B. Schwartz, E. L. Abner, A. Biragyn, U. Masharani, L. Frassetto, R. C. Petersen, B. L. Miller and E. J. Goetzl: Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer’s disease. FASEB J (2014)
[76]K. Maiese, Z. Z. Chong, Y. C. Shang and S. Wang: Novel directions for diabetes mellitus drug discovery. Expert Opin Drug Discov, 8(1), 35-48 (2013)
[77]X. Y. Mao, D. F. Cao, X. Li, J. Y. Yin, Z. B. Wang, Y. Zhang, C. X. Mao, H. H. Zhou and Z. Q. Liu: Huperzine A ameliorates cognitive deficits in streptozotocin-induced diabetic rats. Int J Mol Sci, 15(5), 7667-83 (2014)
[78]Z. Zhao, G. Huang, B. Wang and Y. Zhong: Inhibition of NF-kappaB activation by Pyrrolidine dithiocarbamate partially attenuates hippocampal MMP-9 activation and improves cognitive deficits in streptozotocin-induced diabetic rats. Behav Brain Res, 238, 44-7 (2013)
[79]A. Alttoa, K. Koiv, T. A. Hinsley, A. Brass and J. Harro: Differential gene expression in a rat model of depression based on persistent differences in exploratory activity. Eur Neuropsychopharmacol, 20(5), 288-300 (2010)
[80]A. O. Estevez, K. L. Morgan, N. J. Szewczyk, D. Gems and M. Estevez: The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans. Neurotoxicology, 41, 28-43 (2014)
[81]R. Lakhani, K. R. Vogel, A. Till, J. Liu, S. F. Burnett, K. M. Gibson and S. Subramani: Defects in GABA metabolism affect selective autophagy pathways and are alleviated by mTOR inhibition. EMBO Mol Med (2014)
[82]S. Semaan, J. Wu, Y. Gan, Y. Jin, G. H. Li, J. F. Kerrigan, Y. C. Chang and Y. Huang: Hyperactivation of BDNF-TrkB Signaling Cascades in Human Hypothalamic Hamartoma (HH): A Potential Mechanism Contributing to Epileptogenesis. CNS Neurosci Ther (2014)
[83]K. Y. Yoo, S. H. Kwon, C. H. Lee, B. Yan, J. H. Park, J. H. Ahn, J. H. Choi, T. G. Ohk, J. H. Cho and M. H. Won: FoxO3a changes in pyramidal neurons and expresses in non-pyramidal neurons and astrocytes in the gerbil hippocampal CA1 region after transient cerebral ischemia. Neurochem Res, 37(3), 588-95 (2012)
[84]P. K. Bahia, V. Pugh, K. Hoyland, V. Hensley, M. Rattray and R. J. Williams: Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity. J Neurochem, 123(1), 182-91 (2012)
[85]J. Chen, H. Mao, H. Zou, W. Jin, L. Ni, K. Ke, M. Cao and W. Shi: Up-regulation of ski-interacting protein in rat brain cortex after traumatic brain injury. J Mol Histol, 44(1), 1-10 (2013)
[86]Z. Z. Chong, S. H. Lin and K. Maiese: The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential. J Cereb Blood Flow Metab, 24(7), 728-43 (2004)
[87]M. De Butte-Smith, R. S. Zukin and A. M. Etgen: Effects of global ischemia and estradiol pretreatment on phosphorylation of Akt, CREB and STAT3 in hippocampal CA1 of young and middle-aged female rats. Brain Res, 1471, 118-28 (2012)
[88]A. Domanskyi, H. Alter, M. A. Vogt, P. Gass and I. A. Vinnikov: Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance. Front Cell Neurosci, 8, 275 (2014)
[89]E. C. Genin, N. Caron, R. Vandenbosch, L. Nguyen and B. Malgrange: Concise review: forkhead pathway in the control of adult neurogenesis. Stem Cells, 32(6), 1398-407 (2014)
[90]F. Gilels, S. T. Paquette, J. Zhang, I. Rahman and P. M. White: Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice. J Neurosci, 33(47), 18409-24 (2013)
[91]F. Li, Z. Z. Chong and K. Maiese: Navigating novel mechanisms of cellular plasticity with the NAD+ precursor and nutrient nicotinamide. Front Biosci, 9, 2500-2520 (2004)
[92]W. Liu, X. Liu, H. Yang, X. Zhu, H. Yi, X. Zhu and J. Zhang: Phosphorylated retinoblastoma protein (p-Rb) is involved in neuronal apoptosis after traumatic brain injury in adult rats. J Mol Histol, 44(2), 147-58 (2013)
[93]K. Maiese: FoxO proteins in the nervous system. Anal Cell Pathol (Amst), 2015(Article ID 569392) (2015)
[94]K. Maiese, Z. Z. Chong and Y. C. Shang: OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins. Trends Mol Med, 14(5), 219-27 (2008)
[95]S. Peng, S. Zhao, F. Yan, J. Cheng, L. Huang, H. Chen, Q. Liu, X. Ji and Z. Yuan: HDAC2 selectively regulates FOXO3a-mediated gene transcription during oxidative stress-induced neuronal cell death. J Neurosci, 35(3), 1250-9 (2015)
[96]M. Sertbas, K. Ulgen and T. Cakir: Systematic analysis of transcription-level effects of neurodegenerative diseases on human brain metabolism by a newly reconstructed brain-specific metabolic network. FEBS Open Bio, 4, 542-53 (2014)
[97]T. Tanaka and M. Iino: Knockdown of Sec8 promotes cell-cycle arrest at G/S phase by inducing p21 via control of FOXO proteins. FEBS J (2013)
[98]Q. Xie, Y. Hao, L. Tao, S. Peng, C. Rao, H. Chen, H. You, M. Q. Dong and Z. Yuan: Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death. EMBO Rep, 13(4), 371-377 (2012)
[99]E. Zeldich, C. D. Chen, T. A. Colvin, E. A. Bove-Fenderson, J. Liang, T. B. Tucker Zhou, D. A. Harris and C. R. Abraham: The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem, 289(35), 24700-15 (2014)
[100]M. Albiero, N. Poncina, M. Tjwa, S. Ciciliot, L. Menegazzo, G. Ceolotto, S. Vigili de Kreutzenberg, R. Moura, M. Giorgio, P. Pelicci, A. Avogaro and G. P. Fadini: Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and Sirt1. Diabetes, 63(4), 1353-65 (2014)
[101]D. Angelis, T. D. Fontanez-Nieves and M. Delivoria-Papadopoulos: The Role of Src Kinase in the Caspase-1 Pathway After Hypoxia in the Brain of Newborn Piglets. Neurochem Res (2014)
[102]Z. Z. Chong, S. H. Lin, J. Q. Kang and K. Maiese: The tyrosine phosphatase SHP2 modulates MAP kinase p38 and caspase 1 and 3 to foster neuronal survival. Cell Mol Neurobiol, 23(4-5), 561-78 (2003)
[103]Z. Z. Chong and K. Maiese: The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury. Histol Histopathol, 22(11), 1251-67 (2007)
[104]Y. S. Huang, C. Y. Cheng, S. H. Chueh, D. Y. Hueng, Y. F. Huang, C. M. Chu, S. T. Wu, M. C. Tai, C. M. Liang, M. H. Liao, C. C. Chen, L. H. Shen and K. H. Ma: Involvement of SHP2 in focal adhesion, migration and differentiation of neural stem cells. Brain Dev, 34(8), 674-84 (2012)
[105]A. Jalsrai, T. Numakawa, Y. Ooshima, N. Adachi and H. Kunugi: Phosphatase-mediated intracellular signaling contributes to neuroprotection by flavonoids of Iris tenuifolia. Am J Chin Med, 42(1), 119-30 (2014)
[106]A. Jo, H. Park, S. H. Lee, S. H. Ahn, H. J. Kim, E. M. Park and Y. H. Choi: SHP-2 Binds to Caveolin-1 and Regulates Src Activity via Competitive Inhibition of CSK in Response to H2O2 in Astrocytes. PLoS One, 9(3), e91582 (2014)
[107]J. H. Yun, S. J. Park, A. Jo, J. L. Kang, I. Jou, J. S. Park and Y. H. Choi: Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes. Exp Mol Med, 43(12), 660-8 (2011)
[108]J. A. Burket, A. D. Benson, A. H. Tang and S. I. Deutsch: Rapamycin improves sociability in the BTBR T(+)Itpr3(tf)/J mouse model of autism spectrum disorders. Brain Res Bull, 100, 70-5 (2014)
[109]A. Chen, L. J. Xiong, Y. Tong and M. Mao: Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3K/Akt/mTOR pathway. Mol Med Rep, 8(4), 1011-6 (2013)
[110]A. Francois, A. Rioux-Bilan, N. Quellard, B. Fernandez, T. Janet, D. Chassaing, M. Paccalin, F. Terro and G. Page: Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice. J Neuroinflammation, 11(1), 139 (2014)
[111]C. Gubern, S. Camos, O. Hurtado, R. Rodriguez, V. G. Romera, M. Sobrado, R. Canadas, M. A. Moro, I. Lizasoain, J. Serena, J. Mallolas and M. Castellanos: Characterization of Gcf2/Lrrfip1 in experimental cerebral ischemia and its role as a modulator of Akt, mTOR and beta-catenin signaling pathways. Neuroscience, 268C, 48-65 (2014)
[112]M. Hadamitzky, A. Herring, K. Keyvani, R. Doenlen, U. Krugel, K. Bosche, K. Orlowski, H. Engler and M. Schedlowski: Acute systemic rapamycin induces neurobehavioral alterations in rats. Behav Brain Res, 273, 16-22 (2014)
[113]A. Jenwitheesuk, C. Nopparat, S. Mukda, P. Wongchitrat and P. Govitrapong: Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways. Int J Mol Sci, 15(9), 16848-84 (2014)
[114]M. Ka, G. Condorelli, J. R. Woodgett and W. Y. Kim: mTOR regulates brain morphogenesis by mediating GSK3 signaling. Development, 141(21), 4076-86 (2014)
[115]M. N. Kamarudin, N. A. Mohd Raflee, S. S. Syed Hussein, J. Y. Lo, H. Supriady and H. Abdul Kadir: (R)-(+)-alpha-Lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3beta pathway and suppression of NF-kappabeta-cytokines. Drug Des Devel Ther, 8, 1765-80 (2014)
[116]K. Maiese, Z. Z. Chong, Y. C. Shang and S. Wang: mTOR: on target for novel therapeutic strategies in the nervous system. Trends Mol Med, 19(1), 51-60 (2013)
[117]H. E. Moon, K. Byun, H. W. Park, J. H. Kim, J. Hur, J. S. Park, J. K. Jun, H. S. Kim, S. L. Paek, I. K. Kim, J. H. Hwang, J. W. Kim, D. G. Kim, Y. C. Sung, G. Y. Koh, C. W. Song, B. Lee and S. H. Paek: COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway. Exp Neurobiol, 24(1), 55-70 (2015)
[118]J. Romine, X. Gao, X. M. Xu, K. F. So and J. Chen: The proliferation of amplifying neural progenitor cells is impaired in the aging brain and restored by the mTOR pathway activation. Neurobiol Aging, 36(4), 1716-26 (2015)
[119]N. S. Rozas, J. B. Redell, J. McKenna, 3rd, A. N. Moore, M. J. Gambello and P. K. Dash: Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation. Biochem Biophys Res Commun, 457(4), 635-9 (2015)
[120]X. Zhong, R. Lin, Z. Li, J. Mao and L. Chen: Effects of Salidroside on Cobalt Chloride-Induced Hypoxia Damage and mTOR Signaling Repression in PC12 Cells. Biol Pharm Bull, 37(7), 1199-206 (2014)
[121]S. Lanfranconi, F. Locatelli, S. Corti, L. Candelise, G. P. Comi, P. L. Baron, S. Strazzer, N. Bresolin and A. Bersano: Growth factors in ischemic stroke. J Cell Mol Med, 15(8), 1645-87 (2011)
[122]K. Maiese: Programming apoptosis and autophagy with novel approaches for diabetes mellitus. Curr Neurovasc Res, 12(2), 173-88 (2015)
[123]K. Maiese and L. Boccone: Neuroprotection by peptide growth factors against anoxia and nitric oxide toxicity requires modulation of protein kinase C. J Cereb Blood Flow Metab, 15(3), 440-9 (1995)
[124]D. Mittal, A. Ali, S. Md, S. Baboota, J. K. Sahni and J. Ali: Insights into direct nose to brain delivery: current status and future perspective. Drug Deliv, 21(2), 75-86 (2014)
[125]S. S. Newton, N. M. Fournier and R. S. Duman: Vascular growth factors in neuropsychiatry.Cell Mol Life Sci, 70(10), 1739-52 (2013)
[126]K. Maiese, F. Li and Z. Z. Chong: New avenues of exploration for erythropoietin. Jama, 293(1), 90-5 (2005)
[127]N. Imai, A. Kawamura, M. Higuchi, M. Oh-eda, T. Orita, T. Kawaguchi and N. Ochi: Physicochemical and biological comparison of recombinant human erythropoietin with human urinary erythropoietin. J Biochem (Tokyo), 107(3), 352-9. (1990)
[128]R. Castaneda-Arellano, C. Beas-Zarate, A. I. Feria-Velasco, E. W. Bitar-Alatorre and M. C. Rivera-Cervantes: From neurogenesis to neuroprotection in the epilepsy: signalling by erythropoietin. Front Biosci (Landmark Ed), 19, 1445-55 (2014)
[129]K. Maiese, Z. Z. Chong and Y. C. Shang: Raves and risks for erythropoietin. Cytokine Growth Factor Rev, 19(2), 145-155 (2008)
[130]L. Wang, L. Di and C. T. Noguchi: Erythropoietin, a novel versatile player regulating energy metabolism beyond the erythroid system. Int J Biol Sci, 10(8), 921-39 (2014)
[131]Y. Zhang, L. Wang, S. Dey, M. Alnaeeli, S. Suresh, H. Rogers, R. Teng and C. T. Noguchi: Erythropoietin action in stress response, tissue maintenance and metabolism. Int J Mol Sci, 15(6), 10296-333 (2014)
[132]K. Maiese, Z. Z. Chong, Y. C. Shang and S. Wang: Erythropoietin: new directions for the nervous system. Int J Mol Sci, 13(9), 11102-29 (2012)
[133]K. Maiese, Z. Z. Chong, F. Li and Y. C. Shang: Erythropoietin: elucidating new cellular targets that broaden therapeutic strategies. Prog Neurobiol, 85(2), 194-213 (2008)
[134]C. Bernard: Remarques sur le sécrétion du sucre dans la foie, faites à l’occasion de la communication de M Lehman. Comptes rendus Academies de Sciences, 40, 589-592 (1855)
[135]P. Carnot and C. DeFlandre: Sur l’activite hemopoietique de serum au cours de la regeneration du sang. C R Acad Sci (Paris) 143, 384-386 (1906)
[136]A. J. Erslev: In vitro production of erythropoietin by kidneys perfused with a serum-free solution. Blood, 44(1), 77-85 (1974)
[137]C. Gibelli: Uber den wert des serums anamisch gemachten tiere bei der regeneration des blutes. Arch Exp Pathol Pharmacol, 65, 284-302 (1911)
[138]G. Sandor: Uber die blutbidende wirkung des serums von tieren, die in verdunnter luft gehalten wuren. Z Gesante Exp Med, 82, 633-646 (1932)
[139]K. Jacobs, C. Shoemaker, R. Rudersdorf, S. D. Neill, R. J. Kaufman, A. Mufson, J. Seehra, S. S. Jones, R. Hewick, E. F. Fritsch, M. Kawakita, T. Shimizu and T. Miyake: Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature, 313(6005), 806-10. (1985)
[140]F. K. Lin, S. Suggs, C. H. Lin, J. K. Browne, R. Smalling, J. C. Egrie, K. K. Chen, G. M. Fox, F. Martin, Z. Stabinsky, S. Badrawi, P.-H. Lai and E. Goldwasser: Cloning and expression of the human erythropoietin gene. Proc Natl Acad Sci U S A, 82(22), 7580-4 (1985)
[141]F. Li, Z. Z. Chong and K. Maiese: Erythropoietin on a Tightrope: Balancing Neuronal and Vascular Protection between Intrinsic and Extrinsic Pathways. Neurosignals, 13(6), 265-89 (2004)
[142]A. Palazzuoli, G. Ruocco, M. Pellegrini, C. De Gori, G. Del Castillo, N. Giordano and R. Nuti: The role of erythropoietin stimulating agents in anemic patients with heart failure: solved and unresolved questions. Ther Clin Risk Manag, 10, 641-50 (2014)
[143]E. M. Moore, R. Bellomo and A. D. Nichol: Erythropoietin as a novel brain and kidney protective agent. Anaesth Intensive Care, 39(3), 356-72 (2011)
[144]C. Caprara and C. Grimm: From oxygen to erythropoietin: relevance of hypoxia for retinal development, health and disease. Prog Retin Eye Res, 31(1), 89-119 (2012)
[145]Z. Z. Chong, J. Q. Kang and K. Maiese: Angiogenesis and plasticity: role of erythropoietin in vascular systems.J Hematother Stem Cell Res, 11(6), 863-71 (2002)
[146]S. Kato, M. Aoyama, H. Kakita, H. Hida, I. Kato, T. Ito, T. Goto, M. H. Hussein, K. Sawamoto, H. Togari and K. Asai: Endogenous erythropoietin from astrocyte protects the oligodendrocyte precursor cell against hypoxic and reoxygenation injury. J Neurosci Res, 89(10), 1566-74 (2011)
[147]K. Maiese, F. Li and Z. Z. Chong: Erythropoietin in the brain: can the promise to protect be fulfilled? Trends Pharmacol Sci, 25(11), 577-583 (2004)
[148]S. B. Krantz: Erythropoietin. Blood, 77(3), 419-34. (1991)
[149]K. Maiese, Z. Z. Chong, J. Hou and Y. C. Shang: Erythropoietin and oxidative stress. Curr Neurovasc Res, 5(2), 125-42 (2008)
[150]E. Tsuda, G. Kawanishi, M. Ueda, S. Masuda and R. Sasaki: The role of carbohydrate in recombinant human erythropoietin. Eur J Biochem, 188(2), 405-11. (1990)
[151]E. Uchida, K. Morimoto, N. Kawasaki, Y. Izaki, A. Abdu Said and T. Hayakawa: Effect of active oxygen radicals on protein and carbohydrate moieties of recombinant human erythropoietin. Free Radic Res, 27(3), 311-23. (1997)
[152]T. Toyoda, T. Itai, T. Arakawa, K. H. Aoki and H. Yamaguchi: Stabilization of human recombinant erythropoietin through interactions with the highly branched N-glycans. J Biochem (Tokyo), 128(5), 731-7. (2000)
[153]F. F. Wang, C. K. Kung and E. Goldwasser: Some chemical properties of human erythropoietin. Endocrinology, 116(6), 2286-92. (1985)
[154]K. Reissmann: Studies on the mechanism of erythropoietin stimulation in parabiotic rats during hypoxia. Blood, 5, 347-380 (1950)
[155]K. Maiese: Triple play: Promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus. Biomed Pharmacother, 62(4), 218-232 (2008)
[156]K. Maiese: Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease. Neural Regen Res, 10(4), 518-528 (2015)
[157]A. Guven Bagla, E. Ercan, H. F. Asgun, M. Ickin, F. Ercan, O. Yavuz, S. Bagla and A. Kaplan: Experimental acute myocardial infarction in rats: HIF-1alpha, caspase-3, erythropoietin and erythropoietin receptor expression and the cardioprotective effects of two different erythropoietin doses. Acta Histochem, 115(7), 658-68 (2013)
[158]K. Nishimura, M. Tokida, H. Katsuyama, H. Nakagawa and S. Matsuo: The effect of hemin-induced oxidative stress on erythropoietin production in HepG2 cells. Cell Biol Int (2014)
[159]A. A. Ali, J. A. Coulter, C. H. Ogle, M. M. Migaud, D. G. Hirst, T. Robson and H. O. McCarthy: The contribution of N(2)O(3) to the cytotoxicity of the nitric oxide donor DETA/NO: an emerging role for S-nitrosylation. Biosci Rep, 33(2) (2013)
[160]A. Deng, M. A. Arndt, J. Satriano, P. Singh, T. Rieg, S. Thomson, T. Tang and R. C. Blantz: Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade. Am J Physiol Renal Physiol, 299(6), F1365-73 (2010)
[161]N. Singh, G. Sharma, V. Mishra and R. Raghubir: Hypoxia Inducible Factor-1: Its Potential Role In Cerebral Ischemia. Cell Mol Neurobiol (2012)
[162]K. Teramo, M. A. Kari, M. Eronen, H. Markkanen and V. Hiilesmaa: High amniotic fluid erythropoietin levels are associated with an increased frequency of fetal and neonatal morbidity in type 1 diabetic pregnancies. Diabetologia, 47(10), 1695-703 (2004)
[163]S. J. Korzeniewski, E. Allred, J. W. Logan, R. N. Fichorova, S. Engelke, K. C. Kuban, T. M. O’Shea, N. Paneth, M. Holm, O. Dammann and A. Leviton: Elevated endogenous erythropoietin concentrations are associated with increased risk of brain damage in extremely preterm neonates. PLoS One, 10(3), e0115083 (2015)
[164]S. Masuda, M. Chikuma and R. Sasaki: Insulin-like growth factors and insulin stimulate erythropoietin production in primary cultured astrocytes. Brain Res, 746(1-2), 63-70 (1997)
[165]A. Symeonidis, A. Kouraklis-Symeonidis, A. Psiroyiannis, M. Leotsinidis, V. Kyriazopoulou, P. Vassilakos, A. Vagenakis and N. Zoumbos: Inappropriately low erythropoietin response for the degree of anemia in patients with noninsulin-dependent diabetes mellitus. Ann Hematol, 85(2), 79-85 (2006)
[166]C. F. Tsai, Y. H. Kuo, W. L. Yeh, C. Y. Wu, H. Y. Lin, S. W. Lai, Y. S. Liu, L. H. Wu, J. K. Lu and D. Y. Lu: Regulatory Effects of Caffeic Acid Phenethyl Ester on Neuroinflammation in Microglial Cells. Int J Mol Sci, 16(3), 5572-5589 (2015)
[167]N. Diez-Padrisa, R. Aguilar, S. Machevo, L. Morais, T. Nhampossa, C. O’Callaghan-Gordo, D. Nhalungo, C. Menendez, A. Roca, P. L. Alonso and Q. Bassat: Erythropoietin levels are not independently associated with malaria-attributable severe disease in mozambican children. PLoS ONE, 6(8), e24090 (2011)
[168]C. Stoppe, M. Coburn, A. Fahlenkamp, J. Ney, S. Kraemer, R. Rossaint and A. Goetzenich: Elevated serum concentrations of erythropoietin after xenon anaesthesia in cardiac surgery: secondary analysis of a randomized controlled trial. Br J Anaesth, 114 (4), 701-3 (2015)
[169]N. Kaushal, S. Hegde, J. Lumadue, R. F. Paulson and K. S. Prabhu: The regulation of erythropoiesis by selenium in mice. Antioxid Redox Signal, 14(8), 1403-12 (2011)
[170]Z. Z. Chong, J. Q. Kang and K. Maiese: Erythropoietin: cytoprotection in vascular and neuronal cells. Curr Drug Targets Cardiovasc Haematol Disord, 3(2), 141-54 (2003)
[171]C. L. Li, J. Jiang, Y. Q. Fan, G. S. Fu, J. A. Wang and W. M. Fan: Knockout of the tumor necrosis factor a receptor 1 gene can up-regulate erythropoietin receptor during myocardial ischemia-reperfusion injury in mice. Chin Med J (Engl), 122(5), 566-70 (2009)
[172]Z. Z. Chong, J. Q. Kang and K. Maiese: Hematopoietic factor erythropoietin fosters neuroprotection through novel signal transduction cascades. J Cereb Blood Flow Metab, 22(5), 503-14 (2002)
[173]Z. Z. Chong, F. Li and K. Maiese: Activating Akt and the brain’s resources to drive cellular survival and prevent inflammatory injury. Histol Histopathol, 20(1), 299-315 (2005)
[174]Z. Z. Chong, Y. C. Shang, S. Wang and K. Maiese: ACritical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR. Future Neurol, 7(6), 733-748 (2012)
[175]Y. Fong, Y. C. Lin, C. Y. Wu, H. M. Wang, L. L. Lin, H. L. Chou, Y. N. Teng, S. S. Yuan and C. C. Chiu: The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/beta-catenin-Foxo3a axis. ScientificWorldJournal, 2014, 937051 (2014)
[176]S. Al Sweidi, M. G. Sanchez, M. Bourque, M. Morissette, D. Dluzen and T. Di Paolo: Oestrogen receptors and signalling pathways: implications for neuroprotective effects of sex steroids in Parkinson’s disease. J Neuroendocrinol, 24(1), 48-61 (2012)
[177]K. K. Ambacher, K. B. Pitzul, M. Karajgikar, A. Hamilton, S. S. Ferguson and S. P. Cregan: The JNK-and AKT/GSK3beta-Signaling Pathways Converge to Regulate Puma Induction and Neuronal Apoptosis Induced by Trophic Factor Deprivation. PLoS ONE, 7(10), e46885 (2012)
[178]R. M. Uranga, S. Katz and G. A. Salvador: Enhanced phosphatidylinositol 3-kinase (PI3K)/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress. J Biol Chem, 288 (27), 19773-84 (2013)
[179]X. Zhou, L. Wang, M. Wang, L. Xu, L. Yu, T. Fang and M. Wu: Emodin-induced microglial apoptosis is associated with TRB3 induction. Immunopharmacol Immunotoxicol, 33(4), 594-602 (2011)
[180]J. Branchu, O. Biondi, F. Chali, T. Collin, F. Leroy, K. Mamchaoui, J. Makoukji, C. Pariset, P. Lopes, C. Massaad, C. Chanoine and F. Charbonnier: Shift from extracellular signal-regulated kinase to AKT/cAMP response element-binding protein pathway increases survival-motor-neuron expression in spinal-muscular-atrophy-like mice and patient cells. J Neurosci, 33(10), 4280-94 (2013)
[181]B. Chen, J. A. Van Winkle, P. D. Lyden, J. H. Brown and N. H. Purcell: PHLPP1 gene deletion protects the brain from ischemic injury. J Cereb Blood Flow Metab, 33(2), 196-204 (2013)
[182]L. Bing, J. Wu, J. Zhang, Y. Chen, Z. Hong and H. Zu: DHT Inhibits the Abeta25-35-Induced Apoptosis by Regulation of Seladin-1, Survivin, XIAP, bax, and bcl-xl Expression Through a Rapid PI3-K/Akt Signaling in C6 Glial Cell Lines. Neurochem Res (2014)
[183]Z. Z. Chong, F. Li and K. Maiese: Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways. Cell Signal, 19(6), 1150-62 (2007)
[184]V. Echeverria, R. Zeitlin, S. Burgess, S. Patel, A. Barman, G. Thakur, M. Mamcarz, L. Wang, D. B. Sattelle, D. A. Kirschner, T. Mori, R. M. Leblanc, R. Prabhakar and G. W. Arendash: Cotinine Reduces Amyloid-beta Aggregation and Improves Memory in Alzheimer’s Disease Mice. J Alzheimers Dis (2011)
[185]J. Liang, L. Liu and D. Xing: Photobiomodulation by low-power laser irradiation attenuates Abeta-induced cell apoptosis through the Akt/GSK3beta/beta-catenin pathway. Free Radic Biol Med, 53(7), 1459-67 (2012)
[186]Y. C. Shang, Z. Z. Chong, S. Wang and K. Maiese: Prevention of beta-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL. Aging (Albany NY), 4(3), 187-201 (2012)
[187]Y. C. Shang, Z. Z. Chong, S. Wang and K. Maiese: Tuberous sclerosis protein 2 (TSC2) modulates CCN4 cytoprotection during apoptotic amyloid toxicity in microglia. Curr Neurovasc Res, 10(1), 29-38 (2013)
[188]Y. Wang, Y. X. Wang, T. Liu, P. Y. Law, H. H. Loh, Y. Qiu and H. Z. Chen: mu-Opioid Receptor Attenuates Abeta Oligomers-Induced Neurotoxicity Through mTOR Signaling. CNS Neurosci Ther (2014)
[189]Z. Xue, Y. Guo, S. Zhang, L. Huang, Y. He, R. Fang and Y. Fang: Beta-asarone attenuates amyloid beta-induced autophagy via Akt/mTOR pathway in PC12 cells. Eur J Pharmacol, 741, 195-204 (2014)
[190]S. Zara, M. De Colli, M. Rapino, S. Pacella, C. Nasuti, P. Sozio, A. Di Stefano and A. Cataldi: Ibuprofen and lipoic acid conjugate neuroprotective activity is mediated by Ngb/Akt intracellular signaling pathway in Alzheimer’s disease rat model. Gerontology, 59(3), 250-60 (2013)
[191]K. W. Zeng, X. M. Wang, H. Ko, H. C. Kwon, J. W. Cha and H. O. Yang: Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid beta-protein via the PI3K/Akt/Bad/Bcl(XL)-regulated mitochondrial apoptotic pathway. Eur J Pharmacol, 672(1-3), 45-55 (2011)
[192]J. Zhang, X. Feng, J. Wu, H. Xu, G. Li, D. Zhu, Q. Yue, H. Liu, Y. Zhang, D. Sun, H. Wang and J. Sun: Neuroprotective effects of resveratrol on damages of mouse cortical neurons induced by beta-amyloid through activation of SIRT1/Akt1 pathway. Biofactors, 40(2), 258-267 (2013)
[193]Z. Zhu, J. Yan, W. Jiang, X. G. Yao, J. Chen, L. Chen, C. Li, L. Hu, H. Jiang and X. Shen: Arctigenin effectively ameliorates memory impairment in Alzheimer’s disease model mice targeting both beta-amyloid production and clearance. J Neurosci, 33(32), 13138-49 (2013)
[194]Z. Z. Chong and K. Maiese: Erythropoietin involves the phosphatidylinositol 3-kinase pathway, 14-3-3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity. Br J Pharmacol, 150(7), 839-50 (2007)
[195]Y. F. Ji, L. Zhou, Y. J. Xie, S. M. Xu, J. Zhu, P. Teng, C. Y. Shao, Y. Wang, J. H. Luo and Y. Shen: Upregulation of glutamate transporter GLT-1 by mTOR-Akt-NF-small ka, CyrillicB cascade in astrocytic oxygen-glucose deprivation. Glia, 61(12), 1959-75 (2013)
[196]F. Li, Z. Z. Chong and K. Maiese: Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen synthase kinase-3beta, beta-catenin, and nuclear factor-kappaB. Curr Neurovasc Res, 3(3), 187-201 (2006)
[197]S. Wang, Z. Z. Chong, Y. C. Shang and K. Maiese: Wnt1 inducible signaling pathway protein 1 (WISP1) blocks neurodegeneration through phosphoinositide 3 kinase/Akt1 and apoptotic mitochondrial signaling involving Bad, Bax, Bim, and Bcl-xL. Curr Neurovasc Re s, 9 (1), 20-31 (2012)
[198]F. Zhang, T. Ding, L. Yu, Y. Zhong, H. Dai and M. Yan: Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells. J Pharm Pharmacol, 64(1), 120-7 (2012)
[199]Z. Z. Chong, J. Q. Kang and K. Maiese: Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation, 106(23), 2973-9 (2002)
[200]Z. Rong, R. Pan, Y. Xu, C. Zhang, Y. Cao and D. Liu: Hesperidin pretreatment protects hypoxia-ischemic brain injury in neonatal rat. Neuroscience, 255, 292-9 (2013)
[201]B. N. Seo, J. M. Ryu, S. P. Yun, J. H. Jeon, S. S. Park, K. B. Oh, J. K. Park and H. J. Han: Delphinidin prevents hypoxia-induced mouse embryonic stem cell apoptosis through reduction of intracellular reactive oxygen species-mediated activation of JNK and NF-kappaB, and Akt inhibition. Apoptosis, 18(7), 811-24 (2013)
[202]J. Su, Y. Tang, H. Zhou, L. Liu and Q. Dong: Tissue kallikrein protects neurons from hypoxia/reoxygenation-induced cell injury through Homer1b/c. Cell Signal, 24(11), 2205-15 (2012)
[203]S. Busch, A. Kannt, M. Kolibabka, A. Schlotterer, Q. Wang, J. Lin, Y. Feng, S. Hoffmann, N. Gretz and H. P. Hammes: Systemic treatment with erythropoietin protects the neurovascular unit in a rat model of retinal neurodegeneration. PLoS One, 9(7), e102013 (2014)
[204]Z. Z. Chong, J. Hou, Y. C. Shang, S. Wang and K. Maiese: EPO Relies upon Novel Signaling of Wnt1 that Requires Akt1, FoxO3a, GSK-3beta, and beta-Catenin to Foster Vascular Integrity During Experimental Diabetes. Curr Neurovasc Res, 8(2), 103-20 (2011)
[205]F. Das, N. Dey, B. Venkatesan, B. S. Kasinath, N. Ghosh-Choudhury and G. G. Choudhury: High glucose upregulation of early-onset Parkinson’s disease protein DJ-1 integrates the PRAS40/TORC1 axis to mesangial cell hypertrophy. Cell Signal, 23(8), 1311-9 (2011)
[206]J. Hou, Z. Z. Chong, Y. C. Shang and K. Maiese: FoxO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling. Mol Cell Endocrinol, 321(2), 194-206 (2010)
[207]J. Hou, Z. Z. Chong, Y. C. Shang and K. Maiese: Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation. Curr Neurovasc Res, 7(2), 95-112 (2010)
[208]R. Kimura, M. Okouchi, T. Kato, K. Imaeda, N. Okayama, K. Asai and T. Joh: Epidermal growth factor receptor transactivation is necessary for glucagon-like peptide-1 to protect PC12 cells from apoptosis. Neuroendocrinology, 97(4), 300-8 (2013)
[209]Z. Y. Chang, M. K. Yeh, C. H. Chiang, Y. H. Chen and D. W. Lu: Erythropoietin protects adult retinal ganglion cells against NMDA-, trophic factor withdrawal-, and TNF-alpha-induced damage. PLoS One, 8(1), e55291 (2013)
[210]Z. Z. Chong, J. Q. Kang and K. Maiese: Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways. Br J Pharmacol, 138(6), 1107-1118 (2003)
[211]M. S. Kwon, M. H. Kim, S. H. Kim, K. D. Park, S. H. Yoo, I. U. Oh, S. Pak and Y. J. Seo: Erythropoietin exerts cell protective effect by activating PI3K/Akt and MAPK pathways in C6 Cells. Neurol Res, 36(3), 215-23 (2014)
[212]A. Parvin, R. Pranap, U. Shalini, A. Devendran, J. E. Baker and A. Dhanasekaran: Erythropoietin protects cardiomyocytes from cell death during hypoxia/reperfusion injury through activation of survival signaling pathways. PLoS One, 9(9), e107453 (2014)
[213]Y. Yu, S. R. Shiou, Y. Guo, L. Lu, M. Westerhoff, J. Sun, E. O. Petrof and E. C. Claud: Erythropoietin protects epithelial cells from excessive autophagy and apoptosis in experimental neonatal necrotizing enterocolitis. PLoS One, 8(7), e69620 (2013)
[214]J. Kang, J. Y. Yun, J. Hur, J. A. Kang, J. I. Choi, S. B. Ko, J. Lee, J. Y. Kim, I. C. Hwang, Y. B. Park and H. S. Kim: Erythropoietin priming improves the vasculogenic potential of G-CSF mobilized human peripheral blood mononuclear cells. Cardiovasc Res, 104(1), 171-82 (2014)
[215]Z. Z. Chong, S. H. Lin, J. Q. Kang and K. Maiese: Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8. J Neurosci Res, 71(5), 659-69 (2003)
[216]W. Fu, X. Liao, J. Ruan, X. Li, L. Chen, B. Wang, K. Wang and J. Zhou: Recombinant human erythropoietin preconditioning attenuates liver ischemia reperfusion injury through the phosphatidylinositol-3 kinase/AKT/endothelial nitric oxide synthase pathway. J Surg Res, 183(2), 876-84 (2013)
[217]R. Ma, N. Xiong, C. Huang, Q. Tang, B. Hu, J. Xiang and G. Li: Erythropoietin protects PC12 cells from beta-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway. Neuropharmacology, 56(6-7), 1027-34 (2009)
[218]T. Maurice, M. H. Mustafa, C. Desrumaux, E. Keller, G. Naert, C. G.-B. M. de la, Y. Rodriguez Cruz and J. C. Garcia Rodriguez: Intranasal formulation of erythropoietin (EPO) showed potent protective activity against amyloid toxicity in the Abeta(2)(5)(-)(3)(5) non-transgenic mouse model of Alzheimer’s disease. J Psychopharmacol, 27(11), 1044-57 (2013)
[219]Z. K. Sun, H. Q. Yang, J. Pan, H. Zhen, Z. Q. Wang, S. D. Chen and J. Q. Ding: Protective effects of erythropoietin on tau phosphorylation induced by beta-amyloid. J Neurosci Res, 86(13), 3018-27 (2008)
[220]Y. Bennis, G. Sarlon-Bartoli, B. Guillet, L. Lucas, L. Pellegrini, L. Velly, M. Blot-Chabaud, F. Dignat-Georges, F. Sabatier and P. Pisano: Priming of late endothelial progenitor cells with erythropoietin before transplantation requires the CD131 receptor subunit and enhances their angiogenic potential. J Thromb Haemost, 10(9), 1914-28 (2012)
[221]J. Hou, S. Wang, Y. C. Shang, Z. Z. Chong and K. Maiese: Erythropoietin Employs Cell Longevity Pathways of SIRT1 to Foster Endothelial Vascular Integrity During Oxidant Stress. Curr Neurovasc Res, 8(3), 220-35 (2011)
[222]A. I. Khan, S. M. Coldewey, N. S. Patel, M. Rogazzo, M. Collino, M. M. Yaqoob, P. Radermacher, A. Kapoor and C. Thiemermann: Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the beta-common receptor. Dis Model Mech, 6(4), 1021-30 (2013)
[223]Y. Nakazawa, T. Nishino, Y. Obata, M. Nakazawa, A. Furusu, K. Abe, M. Miyazaki, T. Koji and S. Kohno: Recombinant human erythropoietin attenuates renal tubulointerstitial injury in murine adriamycin-induced nephropathy. J Nephrol, 26(3), 527-33 (2013)
[224]K. H. Su, S. K. Shyue, Y. R. Kou, L. C. Ching, A. N. Chiang, Y. B. Yu, C. Y. Chen, C. C. Pan and T. S. Lee: beta Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase. J Cell Physiol, 226(12), 3330-9 (2011)
[225]H. Toba, Y. Kojima, J. Wang, K. Noda, W. Tian, M. Kobara and T. Nakata: Erythropoietin attenuated vascular dysfunction and inflammation by inhibiting NADPH oxidase-derived superoxide production in nitric oxide synthase-inhibited hypertensive rat aorta. Eur J Pharmacol, 691(1-3), 190-7 (2012)
[226]H. Toba, N. Sawai, M. Morishita, S. Murata, M. Yoshida, K. Nakashima, Y. Morita, M. Kobara and T. Nakata: Chronic treatment with recombinant human erythropoietin exerts renoprotective effects beyond hematopoiesis in streptozotocin-induced diabetic rat. Eur J Pharmacol, 612(1-3), 106-14 (2009)
[227]Y. C. Shang, Z. Z. Chong, S. Wang and K. Maiese: Erythropoietin and Wnt1 Govern Pathways of mTOR, Apaf-1, and XIAP in Inflammatory Microglia. Curr Neurovasc Res, 8(4), 270-285 (2011)
[228]J. Shen, Y. Wu, J. Y. Xu, J. Zhang, S. H. Sinclair, M. Yanoff, G. Xu, W. Li and G. T. Xu: ERK-and Akt-dependent neuroprotection by erythropoietin (EPO) against glyoxal-AGEs via modulation of Bcl-xL, Bax, and BAD. Invest Ophthalmol Vis Sci, 51(1), 35-46 (2010)
[229]G. B. Wang, Y. L. Ni, X. P. Zhou and W. F. Zhang: The AKT/mTOR pathway mediates neuronal protective effects of erythropoietin in sepsis. Mol Cell Biochem, 385(1-2), 125-32 (2014)
[230]K. Maiese: Forkhead Transcription Factors: Vital Elements in Biology and Medicine. Advances in Experimental Medicine and Biology, Springer Science and Business Media, 665(2010)
[231]W. H. Biggs, 3rd, W. K. Cavenee and K. C. Arden: Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm Genome, 12(6), 416-25 (2001)
[232]H. Huang and D. J. Tindall: Dynamic FoxO transcription factors. J Cell Sci, 120(Pt 15), 2479-87 (2007)
[233]K. Maiese, Z. Z. Chong, Y. C. Shang and J. Hou: FoxO proteins: cunning concepts and considerations for the cardiovascular system. Clin Sci (Lond), 116(3), 191-203 (2009)
[234]K. Maiese, Z. Z. Chong and Y. C. Shang: “Sly as a FOXO”: New paths with Forkhead signaling in the brain. Curr Neurovasc Res, 4 (4), 295-302 (2007)
[235]D. L. Trinh, D. W. Scott, R. D. Morin, M. Mendez-Lago, J. An, S. J. Jones, A. J. Mungall, Y. Zhao, J. Schein, C. Steidl, J. M. Connors, R. D. Gascoyne and M. A. Marra: Analysis of FOXO1 mutations in diffuse large B-cell lymphoma. Blood, 121(18), 3666-74 (2013)
[236]S. Carbajo-Pescador, J. L. Mauriz, A. Garcia-Palomo and J. Gonzalez-Gallego: FoxO proteins: regulation and molecular targets in liver cancer. Curr Med Chem, 21(10), 1231-46 (2014)
[237]M. E. Chamorro, S. D. Wenker, D. M. Vota, D. C. Vittori and A. B. Nesse: Signaling pathways of cell proliferation are involved in the differential effect of erythropoietin and its carbamylated derivative. Biochim Biophys Acta, 1833(8), 1960-8 (2013)
[238]P. Scodelaro Bilbao and R. Boland: Extracellular ATP regulates FoxO family of transcription factors and cell cycle progression through PI3K/Akt in MCF-7 cells. Biochim Biophys Acta, 1830(10), 4456-69 (2013)
[239]G. Z. Tao, N. Lehwald, K. Y. Jang, J. Baek, B. Xu, M. B. Omary and K. G. Sylvester: Wnt/beta-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3. J Biol Chem, 288(24), 17214-24 (2013)
[240]C. P. Wong, T. Kaneda, A. H. Hadi and H. Morita: Ceramicine B, a limonoid with anti-lipid droplets accumulation activity from Chisocheton ceramicus. J Nat Med, 68(1), 22-30 (2014)
[241]H. Matsuzaki, H. Daitoku, M. Hatta, H. Aoyama, K. Yoshimochi and A. Fukamizu: Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci U S A, 102(32), 11278-83 (2005)
[242]G. Xu, J. Liu, K. Yoshimoto, G. Chen, T. Iwata, N. Mizusawa, Z. Duan, C. Wan and J. Jiang: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces expression of p27(kip(1)) and FoxO3a in female rat cerebral cortex and PC12 cells. Toxicol Lett, 226(3), 294-302 (2014)
[243]Y. C. Shang, Z. Z. Chong, J. Hou and K. Maiese: Wnt1, FoxO3a, and NF-kappaB oversee microglial integrity and activation during oxidant stress. Cell Signal, 22(9), 1317-29 (2010)
[244]A. Wilk, K. Urbanska, S. Yang, J. Y. Wang, S. Amini, L. Del Valle, F. Peruzzi, L. Meggs and K. Reiss: Insulin-like growth factor-I-forkhead box O transcription factor 3a counteracts high glucose/tumor necrosis factor-alpha-mediated neuronal damage: implications for human immunodeficiency virus encephalitis. J Neurosci Res, 89(2), 183-98 (2011)
[245]N. Hariharan, Y. Maejima, J. Nakae, J. Paik, R. A. Depinho and J. Sadoshima: Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circ Res, 107(12), 1470-82 (2010)
[246]S. Iyer, L. Han, S. M. Bartell, H. N. Kim, I. Gubrij, R. de Cabo, C. A. O’Brien, S. C. Manolagas and M. Almeida: Sirtuin1 (Sirt1) promotes cortical bone formation by preventing beta-catenin sequestration by FoxO transcription factors in osteoblast progenitors. J Biol Chem, 289(35), 24069-78 (2014)
[247]J. Shi, N. Yin, L. L. Xuan, C. S. Yao, A. M. Meng and Q. Hou: Vam3, a derivative of resveratrol, attenuates cigarette smoke-induced autophagy. Acta Pharmacol Sin, 33 (7), 888-96 (2012)
[248]Y. Akasaki, O. Alvarez-Garcia, M. Saito, B. Carames, Y. Iwamoto and M. K. Lotz: FOXO transcription factors support oxidative stress resistance in human chondrocytes. Arthritis Rheumatol, 66(12), 3349-3358 (2014)
[249]V. Balan, G. S. Miller, L. Kaplun, K. Balan, Z. Z. Chong, F. Li, A. Kaplun, M. F. VanBerkum, R. Arking, D. C. Freeman, K. Maiese and G. Tzivion: Life span extension and neuronal cell protection by Drosophila nicotinamidase. J Biol Chem, 283(41), 27810-9 (2008)
[250]Z. Z. Chong, S. Wang, Y. C. Shang and K. Maiese: Targeting cardiovascular disease with novel SIRT1 pathways. Future Cardiol, 8(1), 89-100 (2012)
[251]K. Maiese, Z. Z. Chong, Y. C. Shang and S. Wang: Translating cell survival and cell longevity into treatment strategies with SIRT1. Rom J Morphol Embryol, 52(4), 1173-85 (2011)
[252]A. F. Paraiso, K. L. Mendes and S. H. Santos: Brain activation of SIRT1: role in neuropathology. Mol Neurobiol, 48(3), 681-9 (2013)
[253]W. Wang, C. Yan, J. Zhang, R. Lin, Q. Lin, L. Yang, F. Ren, J. Zhang, M. Ji and Y. Li: SIRT1 inhibits TNF-alpha-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1. Apoptosis, 18 (6), 689-701 (2013)
[254]G. Arunachalam, S. M. Samuel, I. Marei, H. Ding and C. R. Triggle: Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1. Br J Pharmacol, 171(2), 523-35 (2014)
[255]N. D’Onofrio, M. Vitiello, R. Casale, L. Servillo, A. Giovane and M. L. Balestrieri: Sirtuins in vascular diseases: Emerging roles and therapeutic potential. Biochim Biophys Acta, 1852(7), 1311-1322 (2015)
[256]Y. Liu, H. Chen and D. Liu: Mechanistic perspectives of calorie restriction on vascular homeostasis. Sci China Life Sci, 57(8), 742-754 (2014)
[257]S. Xu, P. Bai, P. J. Little and P. Liu: Poly(ADP-ribose) polymerase 1 (PARP1) in atherosclerosis: from molecular mechanisms to therapeutic implications. Med Res Rev, 34 (3), 644-75 (2014)
[258]G. Favero, L. Franceschetti, L. F. Rodella and R. Rezzani: Sirtuins, aging, and cardiovascular risks. Age (Dordr), 37(4), 9804 (2015)
[259]N. Ferrara, B. Rinaldi, G. Corbi, V. Conti, P. Stiuso, S. Boccuti, G. Rengo, F. Rossi and A. Filippelli: Exercise Training Promotes SIRT1 Activity in Aged Rats. Rejuvenation Res, 11(1), 139-150 (2008)
[260]R. R. Alcendor, S. Gao, P. Zhai, D. Zablocki, E. Holle, X. Yu, B. Tian, T. Wagner, S. F. Vatner and J. Sadoshima: Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res, 100(10), 1512-21 (2007)
[261]S. Xiong, G. Salazar, N. Patrushev and R. W. Alexander: FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression. J Biol Chem, 286(7), 5289-99 (2011)
[262]E. H. Hong, S. J. Lee, J. S. Kim, K. H. Lee, H. D. Um, J. H. Kim, S. J. Kim, J. I. Kim and S. G. Hwang: Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase. J Biol Chem, 285(2), 1283-95 (2010)
[263]Z. Gao, J. Zhang, I. Kheterpal, N. Kennedy, R. J. Davis and J. Ye: Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J Biol Chem, 286(25), 22227-34 (2011)
[264]T. Kozako, A. Aikawa, T. Shoji, T. Fujimoto, M. Yoshimitsu, S. Shirasawa, H. Tanaka, S. Honda, H. Shimeno, N. Arima and S. Soeda: High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells. Int J Cancer, 131(9), 2044-55 (2012)
[265]X. F. Qi, Y. J. Li, Z. Y. Chen, S. K. Kim, K. J. Lee and D. Q. Cai: Involvement of the FoxO3a pathway in the ischemia/reperfusion injury of cardiac microvascular endothelial cells. Exp Mol Pathol, 95(2), 242-7 (2013)
[266]Y. Yang, Y. Su, D. Wang, Y. Chen, T. Wu, G. Li, X. Sun and L. Cui: Tanshinol attenuates the deleterious effects of oxidative stress on osteoblastic differentiation via Wnt/FoxO3a signaling. Oxid Med Cell Longev, 2013, 351895 (2013)
[267]K. Lee, Y. Hu, L. Ding, Y. Chen, Y. Takahashi, R. Mott and J. X. Ma: Therapeutic potential of a monoclonal antibody blocking the Wnt pathway in diabetic retinopathy. Diabetes, 61(11), 2948-57 (2012)
[268]K. Maiese: WISP1: Clinical Insights for a Proliferative and Restorative Member of the CCN Family. Curr Neurovasc Res, 11(4), 378-389 (2014)
[269]X. H. Wang, X. Sun, X. W. Meng, Z. W. Lv, Y. J. Du, Y. Zhu, J. Chen, D. X. Kong and S. Z. Jin: beta-catenin siRNA regulation of apoptosis-and angiogenesis-related gene expression in hepatocellular carcinoma cells: potential uses for gene therapy. Oncol Rep, 24(4), 1093-9 (2010)
[270]J. Du, J. D. Klein, F. Hassounah, J. Zhang, C. Zhang and X. H. Wang: Aging increases CCN1 expression leading to muscle senescence. Am J Physiol Cell Physiol, 306(1), C28-36 (2014)
[271]Y. Fu, H. Chang, X. Peng, Q. Bai, L. Yi, Y. Zhou, J. Zhu and M. Mi: Resveratrol inhibits breast cancer stem-like cells and induces autophagy via suppressing Wnt/beta-catenin signaling pathway. PLoS One, 9(7), e102535 (2014)
[272]N. Shah, Y. Morsi and R. Manasseh: From mechanical stimulation to biological pathways in the regulation of stem cell fate. Cell Biochem Funct, 32(4), 309-325 (2014)
[273]T. J. Sun, R. Tao, Y. Q. Han, G. Xu, J. Liu and Y. F. Han: Therapeutic potential of umbilical cord mesenchymal stem cells with Wnt/beta-catenin signaling pathway pre-activated for the treatment of diabetic wounds. Eur Rev Med Pharmacol Sci, 18(17), 2460-4 (2014)
[274]A. Maeda, M. Ono, K. Holmbeck, L. Li, T. M. Kilts, V. Kram, M. L. Noonan, Y. Yoshioka, E. McNerny, M. Tantillo, D. Kohn, K. M. Lyons, P. G. Robey and M. F. Young: WNT1 induced secreted protein-1 (WISP1): A novel regulator of bone turnover and Wnt signaling. J Biol Chem (2015)
[275]F. L’Episcopo, C. Tirolo, S. Caniglia, N. Testa, M. C. Morale, M. F. Serapide, S. Pluchino and B. Marchetti: Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson’s disease. J Mol Cell Biol, 6 (1), 13-26 (2014)
[276]B. Marchetti and S. Pluchino: Wnt your brain be inflamed? Yes, it Wnt! Trends Mol Med, 19 (3), 144-56 (2013)
[277]D. Ortiz-Masia, J. Cosin-Roger, S. Calatayud, C. Hernandez, R. Alos, J. Hinojosa, N. Apostolova, A. Alvarez and M. D. Barrachina: Hypoxic macrophages impair autophagy in epithelial cells through Wnt1: relevance in IBD. Mucosal Immunol, 7(4), 929-38 (2014)
[278]D. J. Klinke, 2nd: Induction of Wnt-inducible signaling protein-1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study. PLoS Comput Biol, 10 (1), e1003409 (2014)
[279]K. Knoblich, H. X. Wang, C. Sharma, A. L. Fletcher, S. J. Turley and M. E. Hemler: Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits beta-catenin degradation. Cell Mol Life Sci, 71(7), 1305-14 (2014)
[280]K. Maiese, F. Li, Z. Z. Chong and Y. C. Shang: The Wnt signaling pathway: Aging gracefully as a protectionist? Pharmacol Ther, 118(1), 58-81 (2008)
[281]H. Y. Park, K. Toume, M. A. Arai, S. K. Sadhu, F. Ahmed and M. Ishibashi: Calotropin: a cardenolide from calotropis gigantea that inhibits Wnt signaling by increasing casein kinase 1alpha in colon cancer cells. Chembiochem, 15(6), 872-8 (2014)
[282]S. Bayod, P. Felice, P. Andres, P. Rosa, A. Camins, M. Pallas and A. M. Canudas: Downregulation of canonical Wnt signaling in hippocampus of SAMP8 mice. Neurobiol Aging (2014)
[283]S. Bayod, I. Menella, S. Sanchez-Roige, J. F. Lalanza, R. M. Escorihuela, A. Camins, M. Pallas and A. M. Canudas: Wnt pathway regulation by long-term moderate exercise in rat hippocampus. Brain Res, 1543, 38-48 (2014)
[284]D. C. Berwick and K. Harvey: The regulation and deregulation of Wnt signaling by PARK genes in health and disease. J Mol Cell Biol, 6(1), 3-12 (2014)
[285]C. Gonzalez-Fernandez, C. M. Fernandez-Martos, S. Shields, E. Arenas and F. J. Rodriguez: Wnts are expressed in the spinal cord of adult mice and are differentially induced after injury. J Neurotrauma (2013)
[286]D. Xu, W. Zhao, G. Pan, M. Qian, X. Zhu, W. Liu, G. Cai and Z. Cui: Expression of Nemo-like kinase after spinal cord injury in rats. J Mol Neurosci, 52(3), 410-8 (2014)
[287]N. Tabatadze, C. Tomas, R. McGonigal, B. Lin, A. Schook and A. Routtenberg: Wnt transmembrane signaling and long-term spatial memory. Hippocampus, 22(6), 1228-41 (2012)
[288]W. Loilome, P. Bungkanjana, A. Techasen, N. Namwat, P. Yongvanit, A. Puapairoj, N. Khuntikeo and G. J. Riggins: Activated macrophages promote Wnt/beta-catenin signaling in cholangiocarcinoma cells. Tumour Biol (2014)
[289]V. Murahovschi, O. Pivovarova, I. Ilkavets, R. M. Dmitrieva, S. Docke, F. Keyhani-Nejad, O. Gogebakan, M. Osterhoff, M. Kemper, S. Hornemann, M. Markova, N. Kloting, M. Stockmann, M. O. Weickert, V. Lamounier-Zepter, P. Neuhaus, A. Konradi, S. Dooley, C. von Loeffelholz, M. Bluher, A. F. Pfeiffer and N. Rudovich: WISP1 is a novel adipokine linked to inflammation in obesity. Diabetes (2014)
[290]S. Wang, Z. Sun, X. Zhang, Z. Li, M. Wu, W. Zhao, H. Wang, T. Chen, H. Yan and J. Zhu: Wnt1 Positively Regulates CD36 Expression via TCF4 and PPAR-gamma in Macrophages. Cell Physiol Biochem, 35(4), 1289-1302 (2015)
[291]F. L’Episcopo, C. Tirolo, N. Testa, S. Caniglia, M. C. Morale, M. Deleidi, M. F. Serapide, S. Pluchino and B. Marchetti: Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson’s Disease Involves Cross Talk between Inflammatory and Wnt/beta-Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair. J Neurosci, 32(6), 2062-2085 (2012)
[292]L. Wei, L. Ding, M. S. Mo, M. Lei, L. Zhang, K. Chen and P. Xu: Wnt3a protects SH-SY5Y cells against 6-hydroxydopamine toxicity by restoration of mitochondria function. Transl Neurodegener, 4, 11 (2015)
[293]F. Pilar-Cuellar, R. Vidal, A. Diaz, E. Castro, S. dos Anjos, J. Pascual-Brazo, R. Linge, V. Vargas, H. Blanco, B. Martinez-Villayandre, A. Pazos and E. M. Valdizan: Neural plasticity and proliferation in the generation of antidepressant effects: hippocampal implication. Neural Plast, 2013, 537265 (2013)
[294]Z. Z. Chong, Y. C. Shang, J. Hou and K. Maiese: Wnt1 neuroprotection translates into improved neurological function during oxidant stress and cerebral ischemia through AKT1 and mitochondrial apoptotic pathways. Oxid Med Cell Longev, 3(2), 153-65 (2010)
[295]X. S. Xing, F. Liu and Z. Y. He: Akt regulates beta-catenin in a rat model of focal cerebral ischemia-reperfusion injury. Mol Med Rep (2014)
[296]Y. Xing, X. Zhang, K. Zhao, L. Cui, L. Wang, L. Dong, Y. Li, Z. Liu, C. Wang, X. Zhang, C. Zhu, H. Qiao, Y. Ji and X. Cao: Beneficial effects of sulindac in focal cerebral ischemia: a positive role in Wnt/beta-catenin pathway. Brain Res, 1482, 71-80 (2012)
[297]E. M. Kawamoto, M. Gleichmann, L. M. Yshii, S. Lima Lde, M. P. Mattson and C. Scavone: Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults. Braz J Med Biol Res, 45(1), 58-67 (2012)
[298]N. Pecina-Slaus: Wnt signal transduction pathway and apoptosis: a review. Cancer Cell Int, 10, 22 (2010)
[299]Y. Peng, B. H. Jiang, P. H. Yang, Z. Cao, X. Shi, M. C. Lin, M. L. He and H. F. Kung: Phosphatidylinositol 3-kinase signaling is involved in neurogenesis during Xenopus embryonic development. J Biol Chem, 279(27), 28509-14 (2004)
[300]S. Wang, Z. Z. Chong, Y. C. Shang and K. Maiese: WISP1 (CCN4) autoregulates its expression and nuclear trafficking of beta-catenin during oxidant stress with limited effects upon neuronal autophagy. Curr Neurovasc Res, 9(2), 89-99 (2012)
[301]B. Berschneider, D. C. Ellwanger, H. A. Baarsma, C. Thiel, C. Shimbori, E. S. White, M. Kolb, P. Neth and M. Konigshoff: miR-92a regulates TGF-beta1-induced WISP1 expression in pulmonary fibrosis. Int J Biochem Cell Biol, 53, 432-41 (2014)
[302]S. Schneider, P. Kloimstein, J. Pammer, W. Brannath, M. Grasl and B. M. Erovic: New diagnostic markers in salivary gland tumors. Eur Arch Otorhinolaryngol, 271(7), 1999-2007 (2014)
[303]M. H. van den Bosch, A. B. Blom, P. L. van Lent, H. M. van Beuningen, E. N. Blaney Davidson, P. M. van der Kraan and W. B. van den Berg: Canonical Wnt signaling skews TGF-beta signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8. Cell Signal, 26(5), 951-8 (2014)
[304]H. Liu, J. Yin, H. Wang, G. Jiang, M. Deng, G. Zhang, X. Bu, S. Cai, J. Du and Z. He: FOXO3a modulates WNT/beta-catenin signaling and suppresses epithelial-to-mesenchymal transition in prostate cancer cells. Cell Signal, 27(3), 510-8 (2015)
[305]M. Almeida, L. Han, M. Martin-Millan, C. A. O’Brien and S. C. Manolagas: Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor-to forkhead box O-mediated transcription. J Biol Chem, 282(37), 27298-305 (2007)
[306]Y. Kashii, M. Uchida, K. Kirito, M. Tanaka, K. Nishijima, M. Toshima, T. Ando, K. Koizumi, T. Endoh, K. Sawada, M. Momoi, Y. Miura, K. Ozawa and N. Komatsu: Amember of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction. Blood, 96(3), 941-9. (2000)
[307]W. J. Bakker, T. B. van Dijk, M. Parren-van Amelsvoort, A. Kolbus, K. Yamamoto, P. Steinlein, R. G. Verhaak, T. W. Mak, H. Beug, B. Lowenberg and M. von Lindern: Differential regulation of Foxo3a target genes in erythropoiesis. Mol Cell Biol, 27(10), 3839-3854 (2007)
[308]D. Bouscary, F. Pene, Y. E. Claessens, O. Muller, S. Chretien, M. Fontenay-Roupie, S. Gisselbrecht, P. Mayeux and C. Lacombe: Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation. Blood, 101(9), 3436-43 (2003)
[309]D. L. Mahmud, G. A. M, D. K. Deb, L. C. Platanias, S. Uddin and A. Wickrema: Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells. Oncogene, 21(10), 1556-62 (2002)
[310]Z. Z. Chong, Y. C. Shang, S. Wang and K. Maiese: PRAS40 Is an Integral Regulatory Component of Erythropoietin mTOR Signaling and Cytoprotection. PLoS ONE, 7(9), e45456 (2012)
[311]W. J. Bakker, M. Blazquez-Domingo, A. Kolbus, J. Besooyen, P. Steinlein, H. Beug, P. J. Coffer, B. Lowenberg, M. von Lindern and T. B. van Dijk: FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. J Cell Biol, 164(2), 175-84 (2004)
[312]K. Maiese, J. Hou, Z. Z. Chong and Y. C. Shang: Erythropoietin, forkhead proteins, and oxidative injury: biomarkers and biology. ScientificWorldJournal, 9, 1072-104 (2009)
[313]H. Zhao, R. Wang, X. Wu, J. Liang, Z. Qi, X. Liu, L. Min, X. Ji and Y. Luo: Erythropoietin delivered via intra-arterial infusion reduces endoplasmic reticulum stress in brain microvessels of rats following cerebral ischemia and reperfusion. J Neuroimmune Pharmaco l, 10 (1), 153-61 (2015)
[314]L. Wang, R. Teng, L. Di, H. Rogers, H. Wu, J. B. Kopp and C. T. Noguchi: PPARalpha and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders. Diabetes, 62(12), 4122-31 (2013)
[315]L. Wang, Y. Jia, H. Rogers, Y. P. Wu, S. Huang and C. T. Noguchi: GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1). J Biol Chem, 287(36), 30157-69 (2012)
[316]Z. Z. Chong, Y. C. Shang and K. Maiese: Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling. Curr Neurovasc Re s, 4 (3), 194-204 (2007)
[317]L. Danielyan, R. Schafer, A. Schulz, T. Ladewig, A. Lourhmati, M. Buadze, A. L. Schmitt, S. Verleysdonk, D. Kabisch, K. Koeppen, G. Siegel, B. Proksch, T. Kluba, A. Eckert, C. Kohle, T. Schoneberg, H. Northoff, M. Schwab and C. H. Gleiter: Survival, neuron-like differentiation and functionality of mesenchymal stem cells in neurotoxic environment: the critical role of erythropoietin. Cell Death Differ, 16(12), 1599-614 (2009)
[318]X. Chen, C. C. Wang, S. M. Song, S. Y. Wei, J. S. Li, S. L. Zhao and B. Li: The administration of erythropoietin attenuates kidney injury induced by ischemia/reperfusion with increased activation of Wnt/beta-catenin signaling. J Formos Med Assoc, 114(5), 430-7 (2015)
[319]K. Maiese: MicroRNAs and Stem Cells to the Rescue. Curr Neurovasc Res (2015)
[320]S. C. Johnson, M. Sangesland, M. Kaeberlein and P. S. Rabinovitch: Modulating mTOR in aging and health. Interdiscip Top Gerontol, 40, 107-27 (2015)
[321]J. Neasta, S. Barak, S. B. Hamida and D. Ron: mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse. J Neurochem, 130(2), 172-84 (2014)
[322]C. Wang, J. T. Yu, D. Miao, Z. C. Wu, M. S. Tan and L. Tan: Targeting the mTOR Signaling Network for Alzheimer’s Disease Therapy. Mol Neurobiol, 49(1), 120-35 (2014)
[323]Z. Z. Chong, Y. C. Shang, L. Zhang, S. Wang and K. Maiese: Mammalian target of rapamycin: hitting the bull’s -eye for neurological disorders. Oxid Med Cell Longev, 3(6), 374-91 (2010)
[324]Z. Z. Chong and K. Maiese: Mammalian Target of Rapamycin Signaling in Diabetic Cardiovascular Disease. Cardiovasc Diabetol, 11(1), 45 (2012)
[325]A. K. Saha, X. J. Xu, E. Lawson, R. Deoliveira, A. E. Brandon, E. W. Kraegen and N. B. Ruderman: Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. Diabetes, 59 (10), 2426-34 (2010)
[326]P. B. Martinez de Morentin, N. Martinez-Sanchez, J. Roa, J. Ferno, R. Nogueiras, M. Tena-Sempere, C. Dieguez and M. Lopez: Hypothalamic mTOR: the rookie energy sensor. Curr Mol Med, 14(1), 3-21 (2014)
[327]Z. Cai, B. Li, K. Li and B. Zhao: Down-regulation of amyloid-beta through AMPK activation by inhibitors of GSK-3beta in SH-SY5Y and SH-SY5Y-AbetaPP695 cells. J Alzheimers Dis, 29(1), 89-98 (2012)
[328]H. Zhao, Z. C. Wang, K. F. Wang and X. Y. Chen: Abeta peptide secretion is reduced by Radix Polygalaeinduced autophagy via activation of the AMPK/mTOR pathway. Mol Med Rep (2015)
[329]L. L. Du, D. M. Chai, L. N. Zhao, X. H. Li, F. C. Zhang, H. B. Zhang, L. B. Liu, K. Wu, R. Liu, J. Z. Wang and X. W. Zhou: AMPK Activation Ameliorates Alzheimer’s Disease-Like Pathology and Spatial Memory Impairment in a Streptozotocin-Induced Alzheimer’s Disease Model in Rats. J Alzheimers Dis (2014)
[330]T. Jiang, J. T. Yu, X. C. Zhu, H. F. Wang, M. S. Tan, L. Cao, Q. Q. Zhang, L. Gao, J. Q. Shi, Y. D. Zhang and L. Tan: Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy. Br J Pharmacol, 171(13), 3146-57 (2014)
[331]N. Moroz, J. J. Carmona, E. Anderson, A. C. Hart, D. A. Sinclair and T. K. Blackwell: Dietary restriction involves NAD-dependent mechanisms and a shift toward oxidative metabolism. Aging Cell, 13 (6), 1075-1085 (2014)
[332]E. Russo, F. Andreozzi, R. Iuliano, V. Dattilo, T. Procopio, G. Fiume, S. Mimmi, N. Perrotti, R. Citraro, G. Sesti, A. Constanti and G. De Sarro: Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release. Brain Behav Immu n, 42, 157-168 (2014)
[333]F. Y. Guan, J. Gu, W. Li, M. Zhang, Y. Ji, J. Li, L. Chen and G. M. Hatch: Compound K protects pancreatic islet cells against apoptosis through inhibition of the AMPK/JNK pathway in type 2 diabetic mice and in MIN6 beta-cells. Life Sci, 107(1-2), 42-9 (2014)
[334]L. Chen, B. Xu, L. Liu, Y. Luo, J. Yin, H. Zhou, W. Chen, T. Shen, X. Han and S. Huang: Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Lab Invest, 90 (5), 762-73 (2010)
[335]A. Salminen, K. Kaarniranta, A. Haapasalo, H. Soininen and M. Hiltunen: AMP-activated protein kinase: a potential player in Alzheimer’s disease. J Neurochem, 118(4), 460-74 (2011)
[336]G. Marfia, L. Madaschi, F. Marra, M. Menarini, D. Bottai, A. Formenti, C. Bellardita, A. M. Di Giulio, S. Carelli and A. Gorio: Adult neural precursors isolated from post mortem brain yield mostly neurons: an erythropoietin-dependent process. Neurobiol Dis, 43(1), 86-98 (2011)
[337]K. P. Sanghera, N. Mathalone, R. Baigi, E. Panov, D. Wang, X. Zhao, H. Hsu, H. Wang, V. Tropepe, M. Ward and S. R. Boyd: The PI3K/Akt/mTOR pathway mediates retinal progenitor cell survival under hypoxic and superoxide stress. Mol Cell Neurosci, 47(2), 145-53 (2011)
[338]M. G. Ryou, G. R. Choudhury, W. Li, A. Winters, F. Yuan, R. Liu and S. H. Yang: Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress. Neuroscience, 301, 193-203 (2015)
[339]L. Wang, L. Di and C. T. Noguchi: AMPK is involved in mediation of erythropoietin influence on metabolic activity and reactive oxygen species production in white adipocytes. Int J Biochem Cell Biol, 54, 1-9 (2014)
[340]M. Andreucci, G. Fuiano, P. Presta, G. Lucisano, F. Leone, L. Fuiano, V. Bisesti, P. Esposito, D. Russo, B. Memoli, T. Faga and A. Michael: Downregulation of cell survival signalling pathways and increased cell damage in hydrogen peroxide-treated human renal proximal tubular cells by alpha-erythropoietin. Cell Prolif, 42 (4), 554-61 (2009)
[341]X. Guo, Y. Chen, Q. Liu, J. Wu, L. Wang, X. Tang, W. Zhao and H. Zhang: Ac-cel, a novel antioxidant, protects against hydrogen peroxide-induced injury in PC12 cells via attenuation of mitochondrial dysfunction. J Mol Neurosc i, 50 (3), 453-61 (2013)
[342]K. Maiese, Z. Z. Chong, Y. C. Shang and S. Wang: Targeting disease through novel pathways of apoptosis and autophagy. Expert Opin Ther Targets, 16(12), 1203-14 (2012)
[343]B. Favaloro, N. Allocati, V. Graziano, C. Di Ilio and V. De Laurenzi: Role of Apoptosis in disease. Aging (Albany NY), 4(5), 330-49 (2012)
[344]J. Folch, F. Junyent, E. Verdaguer, C. Auladell, J. G. Pizarro, C. Beas-Zarate, M. Pallas and A. Camins: Role of cell cycle re-entry in neurons: a common apoptotic mechanism of neuronal cell death. Neurotox Res, 22(3), 195-207 (2012)
[345]A. Q. Nguyen, B. H. Cherry, G. F. Scott, M. G. Ryou and R. T. Mallet: Erythropoietin: Powerful protection of ischemic and post-ischemic brain. Exp Biol Med (Maywood) (2014)
[346]S. Shao, Y. Yang, G. Yuan, M. Zhang and X. Yu: Signaling molecules involved in lipid-induced pancreatic Beta-cell dysfunction. Dna Cell Bio l, 32 (2), 41-9 (2013)
[347]J. Q. Kang, Z. Z. Chong and K. Maiese: Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation. Mol Pharmacol, 64(3), 557-69 (2003)
[348]K. Schutters and C. Reutelingsperger: Phosphatidylserine targeting for diagnosis and treatment of human diseases. Apoptosis, 15 (9), 1072-82 (2010)
[349]G. Viola, R. Bortolozzi, E. Hamel, S. Moro, P. Brun, I. Castagliuolo, M. G. Ferlin and G. Basso: MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells. Biochem Pharmacol, 83(1), 16-26 (2012)
[350]S. R. Haldar, A. Chakrabarty, S. Chowdhury, A. Haldar, S. Sengupta and M. Bhattacharyya: Oxidative Stress-Related Genes in Type 2 Diabetes: Association Analysis and Their Clinical Impact. Biochem Genet (2015)
[351]K. Maiese, Z. Z. Chong, S. Wang and Y. C. Shang: Oxidant Stress and Signal Transduction in the Nervous System with the PI 3-K, Akt, and mTOR Cascade. Int J Mol Sc i, 13 (11), 13830-66 (2013)
[352]H. E. Palma, P. Wolkmer, M. Gallio, M. M. Correa, R. Schmatz, G. R. Thome, L. B. Pereira, V. S. Castro, A. B. Pereira, A. Bueno, L. S. de Oliveira, D. Rosolen, T. R. Mann, B. S. de Cecco, D. L. Graca, S. T. Lopes and C. M. Mazzanti: Oxidative stress parameters in blood, liver, and kidney of diabetic rats treated with curcumin and/or insulin. Mol Cell Biochem, 386(1-2), 199-210 (2014)
[353]C. Bowes Rickman, S. Farsiu, C. A. Toth and M. Klingeborn: Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging. Invest Ophthalmol Vis Sci, 54(14), ORSF68-80 (2013)
[354]J. A. Miret and S. Munne-Bosch: Plant amino acid-derived vitamins: biosynthesis and function. Amino Acids, 46(4), 809-24 (2014)
[355]Y. J. Xu, P. S. Tappia, N. S. Neki and N. S. Dhalla: Prevention of diabetes-induced cardiovascular complications upon treatment with antioxidants. Heart Fail Rev, 19(1), 113-21 (2014)
[356]J. M. Yousef and A. M. Mohamed: Prophylactic role of B vitamins against bulk and zinc oxide nano-particles toxicity induced oxidative DNA damage and apoptosis in rat livers. Pak J Pharm Sci, 28(1), 175-84 (2015)
[357]K. Rjiba-Touati, I. Ayed-Boussema, Y. Guedri, A. Achour, H. Bacha and S. Abid-Essefi: Effect of recombinant human erythropoietin on mitomycin C-induced oxidative stress and genotoxicity in rat kidney and heart tissues. Hum Exp Toxicol (2015)
[358]L. Moreira, J. M. Beirao, I. Beirao and P. P. Costa: Oligomeric TTR V30M aggregates compromise cell viability, erythropoietin gene expression and promoter activity in the human hepatoma cell line Hep3B. Amyloid, 1-7 (2015)
[359]T. Yu, L. Li, T. Chen, Z. Liu, H. Liu and Z. Li: Erythropoietin attenuates advanced glycation endproducts-induced toxicity of schwann cells in vitro. Neurochem Res, 40(4), 698-712 (2015)
[360]X. Zhang, S. Dong, Y. Qin and X. Bian: Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms. Mol Med Rep, 11(5), 3317-29 (2015)
[361]T. Ishii, T. Asai, T. Fukuta, D. Oyama, N. Yasuda, Y. Agato, K. Shimizu, T. Minamino and N. Oku: A single injection of liposomal asialo-erythropoietin improves motor function deficit caused by cerebral ischemia/reperfusion. Int J Pharm, 439(1-2), 269-74 (2012)
[362]Z. Z. Chong, F. Li and K. Maiese: Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity. Curr Neurovasc Res, 2(5), 387-99 (2005)
[363]P. Esmaeili Tazangi, S. M. Moosavi, M. Shabani and M. Haghani: Erythropoietin improves synaptic plasticity and memory deficits by decrease of the neurotransmitter release probability in the rat model of Alzheimer’s disease. Pharmacol Biochem Behav, 130, 15-21 (2015)
[364]S. T. Lee, K. Chu, J. E. Park, K. H. Jung, D. Jeon, J. Y. Lim, S. K. Lee, M. Kim and J. K. Roh: Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimer’s disease models. J Neurochem, 120(1), 115-24 (2012)
[365]P. E. Sanchez, R. P. Fares, J. J. Risso, C. Bonnet, S. Bouvard, M. Le-Cavorsin, B. Georges, C. Moulin, A. Belmeguenai, J. Bodennec, A. Morales, J. M. Pequignot, E. E. Baulieu, R. A. Levine and L. Bezin: Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons. Proc Natl Acad Sci U S A, 106(24), 9848-53 (2009)
[366]J. Soliz, J. J. Thomsen, C. Soulage, C. Lundby and M. Gassmann: Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin. Am J Physiol Regul Integr Comp Physiol, 296(6), R1837-46 (2009)
[367]C. Caprara, C. Britschgi, M. Samardzija and C. Grimm: The erythropoietin receptor is not required for the development, function, and aging of rods and cells in the retinal periphery. Mol Vis, 20, 307-24 (2014)
[368]W. Shen, S. H. Chung, M. R. Irhimeh, S. Li, S. R. Lee and M. C. Gillies: Systemic Administration of Erythropoietin Inhibits Retinopathy in RCS Rats. PLoS One, 9(8), e104759 (2014)
[369]D. Choi, S. A. Schroer, S. Y. Lu, L. Wang, X. Wu, Y. Liu, Y. Zhang, H. Y. Gaisano, K. U. Wagner, H. Wu, R. Retnakaran and M. Woo: Erythropoietin protects against diabetes through direct effects on pancreatic beta cells. J Exp Med, 207 (13), 2831-42 (2010)
[370]T. Yu, L. Li, Y. Bi, Z. Liu, H. Liu and Z. Li: Erythropoietin attenuates oxidative stress and apoptosis in Schwann cells isolated from streptozotocin-induced diabetic rats. J Pharm Pharmacol (2014)
[371]Z. Z. Chong, J. Q. Kang and K. Maiese: Apaf-1, Bcl-xL, Cytochrome c, and Caspase-9 Form the Critical Elements for Cerebral Vascular Protection by Erythropoietin. J Cereb Blood Flow Metab, 23(3), 320-30 (2003)
[372]K. R. Dimitrova and I. M. Leitman: Intramyocardial transplantation of endothelial progenitor cells and erythropoietin: a new scope for the treatment of cardiovascular disease. J Surg Res, 183 (2), 550-2 (2013)
[373]E. Gammella, C. Leuenberger, M. Gassmann and L. Ostergaard: Evidence of synergistic/additive effects of sildenafil and erythropoietin in enhancing survival and migration of hypoxic endothelial cells. Am J Physiol Lung Cell Mol Physiol, 304(4), L230-9 (2013)
[374]S. Hamed, D. Egozi, D. Kruchevsky, L. Teot, A. Gilhar and Y. Ullmann: Erythropoietin improves the survival of fat tissue after its transplantation in nude mice. PLoS ONE, 5(11), e13986 (2010)
[375]S. Hamed, Y. Ullmann, D. Egozi, E. Daod, E. Hellou, M. Ashkar, A. Gilhar and L. Teot: Fibronectin potentiates topical erythropoietin-induced wound repair in diabetic mice. J Invest Dermatol, 131(6), 1365-74 (2011)
[376]M. Kamianowska, M. Szczepanski and E. Skrzydlewska: Effects of erythropoietin on ICAM-1 and PECAM-1 expressions on human umbilical vein endothelial cells subjected to oxidative stress. Cell Biochem Funct, 29(6), 437-41 (2011)
[377]W. S. Bond and T. S. Rex: Evidence That Erythropoietin Modulates Neuroinflammation through Differential Action on Neurons, Astrocytes, and Microglia. Front Immunol, 5, 523 (2014)
[378]M. M. Loeliger, A. Mackintosh, R. De Matteo, R. Harding and S. M. Rees: Erythropoietin protects the developing retina in an ovine model of endotoxin-induced retinal injury. Invest Ophthalmol Vis Sci, 52(5), 2656-61 (2011)
[379]N. Miljus, S. Heibeck, M. Jarrar, M. Micke, D. Ostrowski, H. Ehrenreich and R. Heinrich: Erythropoietin-mediated protection of insect brain neurons involves JAK and STAT but not PI3K transduction pathways. Neuroscience, 258, 218-27 (2014)
[380]S. Pankratova, B. Gu, D. Kiryushko, I. Korshunova, L. B. Kohler, M. Rathje, E. Bock and V. Berezin: Anew agonist of the erythropoietin receptor, Epobis, induces neurite outgrowth and promotes neuronal survival. J Neurochem, 121(6), 915-23 (2012)
[381]S. D. Wenker, M. E. Chamorro, D. C. Vittori and A. B. Nesse: Protective action of erythropoietin on neuronal damage induced by activated microglia. FEBS J, 280(7), 1630-42 (2013)
[382]T. F. Zhou and J. G. Yu: Recombinant human erythropoietin attenuates neuronal apoptosis and cognitive defects via JAK2/STAT3 signaling in experimental endotoxemia. J Surg Res, 183 (1), 304-12 (2013)
[383]A. Lourhmati, G. H. Buniatian, C. Paul, S. Verleysdonk, R. Buecheler, M. Buadze, B. Proksch, M. Schwab, C. H. Gleiter and L. Danielyan: Age-dependent astroglial vulnerability to hypoxia and glutamate: the role for erythropoietin. PLoS One, 8(10), e77182 (2013)
[384]R. Schafer, L. Mueller, R. Buecheler, B. Proksch, M. Schwab, C. H. Gleiter and L. Danielyan: Interplay between Endothelin and Erythropoietin in Astroglia: The Role in Protection against Hypoxia. Int J Mol Sci, 15 (2), 2858-75 (2014)
[385]M. Yamada, C. Burke, P. Colditz, D. W. Johnson and G. C. Gobe: Erythropoietin protects against apoptosis and increases expression of non-neuronal cell markers in the hypoxia-injured developing brain. J Pathol, 224 (1), 101-9 (2011)
[386]N. Kaneko, E. Kako and K. Sawamoto: Enhancement of ventricular-subventricular zone-derived neurogenesis and oligodendrogenesis by erythropoietin and its derivatives. Front Cell Neurosci, 7, 235 (2013)
[387]Y. Xu, Y. Tian, H. J. Wei, J. Chen, J. F. Dong, A. Zacharek and J. N. Zhang: Erythropoietin increases circulating endothelial progenitor cells and reduces the formation and progression of cerebral aneurysm in rats. Neuroscience, 181, 292-9 (2011)
[388]M. H. Hussein, G. A. Daoud, H. Kakita, S. Kato, T. Goto, M. Kamei, K. Goto, M. Nobata, Y. Ozaki, T. Ito, S. Fukuda, I. Kato, S. Suzuki, H. Sobajima, F. Hara, T. Hashimoto and H. Togari: High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns. Free Radic Res, 44(4), 422-9 (2010)
[389]K. H. Park, N. Y. Choi, S. H. Koh, H. H. Park, Y. S. Kim, M. J. Kim, S. J. Lee, H. J. Yu, K. Y. Lee, Y. J. Lee and H. T. Kim: L-DOPA neurotoxicity is prevented by neuroprotective effects of erythropoietin. Neurotoxicology, 32(6), 879-87 (2011)
[390]Z. Y. Wang, L. J. Shen, L. Tu, D. N. Hu, G. Y. Liu, Z. L. Zhou, Y. Lin, L. H. Chen and J. Qu: Erythropoietin protects retinal pigment epithelial cells from oxidative damage. Free Radic Biol Med, 46(8), 1032-41 (2009)
[391]J. Dang, R. Jia, Y. Tu, S. Xiao and G. Ding: Erythropoietin prevents reactive oxygen species generation and renal tubular cell apoptosis at high glucose level. Biomed Pharmacothe r, 64 (10), 681-5 (2010)
[392]A. Francois, F. Terro, N. Quellard, B. Fernandez, D. Chassaing, T. Janet, A. Rioux-Bilan, M. Paccalin and G. Page: Impairment of autophagy in the central nervous system during lipopolysaccharide-induced inflammatory stress in mice. Mol Brain, 7(1), 56 (2014)
[393]H. Vakifahmetoglu-Norberg, H. G. Xia and J. Yuan: Pharmacologic agents targeting autophagy. J Clin Invest, 125(1), 5-13 (2015)
[394]C. He, H. Zhu, H. Li, M. H. Zou and Z. Xie: Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes. Diabetes, 62(4), 1270-81 (2013)
[395]K. A. Kim, Y. J. Shin, M. Akram, E. S. Kim, K. W. Choi, H. Suh, C. H. Lee and O. N. Bae: High glucose condition induces autophagy in endothelial progenitor cells contributing to angiogenic impairment. Biol Pharm Bull, 37 (7), 1248-52 (2014)
[396]Y. M. Lim, H. Lim, K. Y. Hur, W. Quan, H. Y. Lee, H. Cheon, D. Ryu, S. H. Koo, H. L. Kim, J. Kim, M. Komatsu and M. S. Lee: Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes. Nat Commun, 5, 4934 (2014)
[397]A. Bargiela, E. Cerro-Herreros, J. M. Fernandez-Costa, J. J. Vilchez, B. Llamusi and R. Artero: Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model. Dis Model Mech, 8(7), 679-90 (2015)
[398]W. Dong, R. Wang, L. N. Ma, B. L. Xu, J. S. Zhang, Z. W. Zhao, Y. L. Wang and X. Zhang: Influence of age-related learning and memory capacity of mice: different effects of a high and low caloric diet. Aging Clin Exp Res (2015)
[399]I. Bendix, C. Schulze, C. Haefen, A. Gellhaus, S. Endesfelder, R. Heumann, U. Felderhoff-Mueser and M. Sifringer: Erythropoietin modulates autophagy signaling in the developing rat brain in an in vivo model of oxygen-toxicity. Int J Mol Sci, 13(10), 12939-51 (2012)
[400]W. Jang, H. J. Kim, H. Li, K. D. Jo, M. K. Lee and H. O. Yang: The Neuroprotective Effect of Erythropoietin on Rotenone-Induced Neurotoxicity in SH-SY5Y Cells Through the Induction of Autophagy. Mol Neurobiol (2015)
[401]R. Bierer, M. C. Peceny, C. H. Hartenberger and R. K. Ohls: Erythropoietin concentrations and neurodevelopmental outcome in preterm infants. Pediatrics, 118(3), e635-40 (2006)
[402]R. H. Leuchter, L. Gui, A. Poncet, C. Hagmann, G. A. Lodygensky, E. Martin, B. Koller, A. Darque, H. U. Bucher and P. S. Huppi: Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age. JAMA, 312(8), 817-24 (2014)
[403]C. S. Robertson, H. J. Hannay, J. M. Yamal, S. Gopinath, J. C. Goodman, B. C. Tilley, A. Baldwin, L. Rivera Lara, H. Saucedo-Crespo, O. Ahmed, S. Sadasivan, L. Ponce, J. Cruz-Navarro, H. Shahin, I. P. Aisiku, P. Doshi, A. Valadka, L. Neipert, J. M. Waguspack, M. L. Rubin, J. S. Benoit and P. Swank: Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial. JAMA, 312(1), 36-47 (2014)
[404]S. C. Cramer and M. D. Hill: Human choriogonadotropin and epoetin alfa in acute ischemic stroke patients (REGENESIS-LED trial). Int J Strok e, 9 (3), 321-7 (2014)
[405]R. Castelli, G. L. Deliliers, R. Colombo, G. Moreo, P. Gallipoli and G. Pantaleo: Biosimilar epoetin in elderly patients with low-risk myelodysplastic syndromes improves anemia, quality of life, and brain function. Ann Hematol, 93(9), 1523-9 (2014)
[406]W. Jang, J. Park, K. J. Shin, J. S. Kim, J. S. Kim, J. Youn, J. W. Cho, E. Oh, J. Y. Ahn, K. W. Oh and H. T. Kim: Safety and efficacy of recombinant human erythropoietin treatment of non-motor symptoms in Parkinson’s disease. J Neurol Sci, 337(1-2), 47-54 (2014)
[407]S. S. Najjar, S. V. Rao, C. Melloni, S. V. Raman, T. J. Povsic, L. Melton, G. W. Barsness, K. Prather, J. F. Heitner, R. Kilaru, L. Gruberg, V. Hasselblad, A. B. Greenbaum, M. Patel, R. J. Kim, M. Talan, L. Ferrucci, D. L. Longo, E. G. Lakatta and R. A. Harrington: Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. Jama, 305(18), 1863-72 (2011)
[408]N. Taniguchi, T. Nakamura, T. Sawada, K. Matsubara, K. Furukawa, M. Hadase, Y. Nakahara and H. Matsubara: Erythropoietin prevention trial of coronary restenosis and cardiac remodeling after ST-elevated acute myocardial infarction (EPOC-AMI): a pilot, randomized, placebo-controlled study. Circ J, 74(11), 2365-71 (2010)
[409]Y. Wen, J. Xu, X. Ma and Q. Gao: High-dose erythropoietin in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials. Am J Cardiovasc Drugs, 13(6), 435-42 (2013)
[410]M. W. Bergmann, S. Haufe, F. von Knobelsdorff-Brenkenhoff, H. Mehling, R. Wassmuth, I. Munch, A. Busjahn, J. Schulz-Menger, J. Jordan, F. C. Luft and R. Dietz: Apilot study of chronic, low-dose epoetin-{beta} following percutaneous coronary intervention suggests safety, feasibility, and efficacy in patients with symptomatic ischaemic heart failure. Eur J Heart Fail, 13(5), 560-8 (2011)
[411]B. D. Hedley, A. L. Allan and A. Xenocostas: The role of erythropoietin and erythropoiesis-stimulating agents in tumor progression. Clin Cancer Res, 17(20), 6373-80 (2011)
[412]K. Maiese, F. Li and Z. Z. Chong: Erythropoietin and cancer. JAMA, 293(15), 1858-1859 (2005)
[413]C. Zhang, Z. Li, Q. Cao, C. Qin, H. Cai, H. Zhou, J. Qian, L. Tao, X. Ju and C. Yin: Association of erythropoietin gene rs576236 polymorphism and risk of adrenal tumors in a Chinese population. J Biomed Res, 28(6), 456-461 (2014)
[414]M. Li, Q. Li, Y. H. Zhang, Z. Y. Tian, H. X. Ma, J. Zhao, S. Q. Xie and C. J. Wang: Antitumor effects and preliminary systemic toxicity of ANISpm in vivo and in vitro. Anticancer Drugs, 24(1), 32-42 (2013)
[415]K. Maiese: Therapeutic targets for cancer: current concepts with PI 3-K, Akt, & mTOR. Indian J Med Res, 137 (2), 243-6 (2013)
[416]R. Malla, C. R. Ashby, Jr., N. K. Narayanan, B. Narayanan, J. S. Faridi and A. K. Tiwari: Proline-rich AKT substrate of 40-kDa (PRAS40) in the pathophysiology of cancer. Biochem Biophys Res Commun (2015)
[417]F. Barbieri, M. Albertelli, F. Grillo, A. Mohamed, A. Saveanu, A. Barlier, D. Ferone and T. Florio: Neuroendocrine tumors: insights into innovative therapeutic options and rational development of targeted therapies. Drug Discov Today, 19(4), 458-468 (2014)
[418]V. N. Kolev, Q. G. Wright, C. M. Vidal, J. E. Ring, I. M. Shapiro, J. Ricono, D. T. Weaver, M. V. Padval, J. A. Pachter and Q. Xu: PI3K/mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells. Cancer Res, 75(2), 446-55 (2015)
[419]K. Maiese: Neuronal Activity, Mitogens, and mTOR: Overcoming the Hurdles for the Treatment of Glioblastoma Multiforme. J Transl Sci, 1(1), 2 (2015)
[420]Z. H. Yang, R. Zheng, Y. Gao, Q. Zhang and H. Zhang: Abnormal gene expression and gene fusion in lung adenocarcinoma with high-throughput RNA sequencing. Cancer Gene The r, 21 (2), 74-82 (2014)
[421]B. Zhou, J. S. Damrauer, S. T. Bailey, T. Hadzic, Y. Jeong, K. Clark, C. Fan, L. Murphy, C. Y. Lee, M. A. Troester, C. R. Miller, J. Jin, D. Darr, C. M. Perou, R. L. Levine, M. Diehn and W. Y. Kim: Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal. J Clin Invest, 124 (2), 553-63 (2014)
[422]H. Skali, H. H. Parving, P. S. Parfrey, E. A. Burdmann, E. F. Lewis, P. Ivanovich, S. R. Keithi-Reddy, J. B. McGill, J. J. McMurray, A. K. Singh, S. D. Solomon, H. Uno and M. A. Pfeffer: Stroke in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia treated with Darbepoetin Alfa: the trial to reduce cardiovascular events with Aranesp therapy (TREAT) experience. Circulation, 124(25), 2903-8 (2011)
[423]T. Frietsch, M. H. Maurer, J. Vogel, M. Gassmann, W. Kuschinsky and K. F. Waschke: Reduced cerebral blood flow but elevated cerebral glucose metabolic rate in erythropoietin overexpressing transgenic mice with excessive erythrocytosis. J Cereb Blood Flow Metab, 27(3), 469-76 (2007)
[424]S. M. Bode-Boger, R. H. Boger, M. Kuhn, J. Radermacher and J. C. Frolich: Recombinant human erythropoietin enhances vasoconstrictor tone via endothelin-1 and constrictor prostanoids. Kidney Int, 50(4), 1255-61. (1996)
[425]T. De Palo, M. Giordano, F. Palumbo, R. Bellantuono, G. Messina, V. Colella and A. D. Caringella: Clinical experience with darbepoietin alfa (NESP) in children undergoing hemodialysis. Pediatr Nephrol, 19(3), 337-40 (2004)
[426]F. Semeraro, A. Cancarini, F. Morescalchi, M. R. Romano, R. dell’Omo, G. Ruggeri, L. Agnifili and C. Costagliola: Serum and intraocular concentrations of erythropoietin and vascular endothelial growth factor in patients with type 2 diabetes and proliferative retinopathy. Diabetes Metab, 40(6), 445-51 (2014)
[427]O. O. Ogunshola, M. Moransard and M. Gassmann: Constitutive excessive erythrocytosis causes inflammation and increased vascular permeability in aged mouse brain. Brain Re s, 1531, 48-57 (2013)
[428]Y. C. Shang, Z. Z. Chong, S. Wang and K. Maiese: WNT1 Inducible Signaling Pathway Protein 1 (WISP1) Targets PRAS40 to Govern beta-Amyloid Apoptotic Injury of Microglia. Curr Neurovasc Res, 9(4), 239-249 (2012)
[429]N. Shahani, W. Pryor, S. Swarnkar, N. Kholodilov, G. Thinakaran, R. E. Burke and S. Subramaniam: Rheb GTPase regulates beta-secretase levels and amyloid beta generation. J Biol Chem, 289(9), 5799-808 (2014)
[430]T. Ma, C. A. Hoeffer, E. Capetillo-Zarate, F. Yu, H. Wong, M. T. Lin, D. Tampellini, E. Klann, R. D. Blitzer and G. K. Gouras: Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer’s disease. PLoS One, 5(9) (2010)
[431]T. Jiang, J. T. Yu, X. C. Zhu, M. S. Tan, H. F. Wang, L. Cao, Q. Q. Zhang, J. Q. Shi, L. Gao, H. Qin, Y. D. Zhang and L. Tan: Temsirolimus promotes autophagic clearance of amyloid-beta and provides protective effects in cellular and animal models of Alzheimer’s disease. Pharmacol Res, 81C, 54-63 (2014)
Article Metrics
Download
- Contents
Information
Download
Contents
Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
1 Cellular and Molecular Signaling, Newark, New Jersey 07101, USA
Abstract
Globally, greater than 30 million individuals are afflicted with disorders of the nervous system accompanied by tens of thousands of new cases annually with limited, if any, treatment options. Erythropoietin (EPO) offers an exciting and novel therapeutic strategy to address both acute and chronic neurodegenerative disorders. EPO governs a number of critical protective and regenerative mechanisms that can impact apoptotic and autophagic programmed cell death pathways through protein kinase B (Akt), sirtuins, mammalian forkhead transcription factors, and wingless signaling. Translation of the cytoprotective pathways of EPO into clinically effective treatments for some neurodegenerative disorders has been promising, but additional work is necessary. In particular, development of new treatments with erythropoiesis-stimulating agents such as EPO brings several important challenges that involve detrimental vascular outcomes and tumorigenesis. Future work that can effectively and safely harness the complexity of the signaling pathways of EPO will be vital for the fruitful treatment of disorders of the nervous system.
Keywords
- Akt
- AMPK
- apoptosis
- autophagy
- erythropoietin
- forkhead
- FoxO
- mTOR
- oxidative stress
- rapamycin
- sirtuin
- SIRT1
- stem cells
- trauma
- WISP1
- Wnt
- Review
References
- [1] A. Hayutin: Global demographic shifts create challenges and opportunities. PREA Quarterly, (Fall), 46-53 (2007)
- [2] A. M. Minino: Death in the United States, 2011. NCHS Data Brief (115), 1-8 (2013)
- [3] World Health Organization: Description of the global burden of NCDs, their risk factors and determinants. Global status report on noncommunicable diseases 2010 (April), 1-176 (2011)
- [4] K. Maiese: SIRT1 and stem cells: In the forefront with cardiovascular disease, neurodegeneration and cancer. World J Stem Cells, 7(2), 235-42 (2015)
- [5] A. Martin, C. A. Tegla, C. D. Cudrici, A. M. Kruszewski, P. Azimzadeh, D. Boodhoo, A. P. Mekala, V. Rus and H. Rus: Role of SIRT1 in autoimmune demyelination and neurodegeneration. Immunol Res, 61 (3), 187-97 (2015)
- [6] K. Maiese: Driving neural regeneration through the mammalian target of rapamycin. Neural Regen Res, 9(15), 1413-7 (2014)
- [7] K. Maiese: Taking aim at Alzheimer’s disease through the mammalian target of rapamycin. Ann Med, 46(8), 587-596 (2014)
- [8] K. Maiese, Z. Z. Chong, J. Hou and Y. C. Shang: New strategies for Alzheimer’s disease and cognitive impairment. Oxid Med Cell Longev, 2(5), 279-89 (2009)
- [9] A. Agis-Torres, M. Solhuber, M. Fernandez and J. M. Sanchez-Montero: Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer’s Disease. Curr Neuropharmacol, 12(1), 2-36 (2014)
- [10] C. M. Filley, Y. D. Rollins, C. A. Anderson, D. B. Arciniegas, K. L. Howard, J. R. Murrell, P. J. Boyer, B. K. Kleinschmidt-DeMasters and B. Ghetti: The genetics of very early onset al zheimer disease. Cogn Behav Neurol, 20(3), 149-56 (2007)
- [11] Z. Z. Chong, Y. C. Shang, S. Wang and K. Maiese: Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin. Prog Neurobiol, 99(2), 128-148 (2012)
- [12] A. K. Mishra, M. S. Ur Rasheed, S. Shukla, M. K. Tripathi, A. Dixit and M. P. Singh: Aberrant Autophagy and Parkinsonism: Does Correction Rescue from Disease Progression? Mol Neurobiol (2014)
- [13] K. Maiese: Cutting through the Complexities of mTOR for the Treatment of Stroke. Curr Neurovasc Res, 11 (2), 177-186 (2014)
- [14] V. P. Nakka, P. Prakash-Babu and R. Vemuganti: Crosstalk Between Endoplasmic Reticulum Stress, Oxidative Stress, and Autophagy: Potential Therapeutic Targets for Acute CNS Injuries. Mol Neurobiol (2014)
- [15] W. Chen, Y. Sun, K. Liu and X. Sun: Autophagy: a double-edged sword for neuronal survival after cerebral ischemia. Neural Regen Res, 9 (12), 1210-6 (2014)
- [16] K. Maiese: mTOR: Driving apoptosis and autophagy for neurocardiac complications of diabetes mellitus. World J Diabetes, 6(2), 217-24 (2015)
- [17] A. M. Minino and S. L. Murphy: Death in the United States, 2010. NCHS Data Brief (99), 1-8 (2012)
- [18] N. Esser, N. Paquot and A. J. Scheen: Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease. Expert Opin Investig Drugs, 24(3), 283-307 (2015)
- [19] K. Maiese: New Insights for Oxidative Stress and Diabetes Mellitus. Oxid Med Cell Longev, 2015(Article ID 875961) (2015)
- [20] Z. Z. Chong, F. Li and K. Maiese: Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease. Prog Neurobiol, 75(3), 207-46 (2005)
- [21] G. Harish, A. Mahadevan, N. Pruthi, S. K. Sreenivasamurthy, V. N. Puttamallesh, T. S. Keshava Prasad, S. K. Shankar and M. S. M: Characterization of traumatic brain injury in human brains reveals distinct cellular and molecular changes in contusion and pericontusion. J Neurochem (2015)
- [22] J. Lee, X. Gu, L. Wei, Z. Wei, T. A. Dix and S. P. Yu: Therapeutic Effects of Pharmacologically induced Hypothermia against Traumatic Brain Injury in Mice. J Neurotrauma (2014)
- [23] K. Maiese: Coma and impaired consciousness. The Merck Manual, 19th Professional Edition (2011)
- [24] J. W. Wang, H. D. Wang, Z. X. Cong, X. M. Zhou, J. G. Xu, Y. Jia and Y. Ding: Puerarin ameliorates oxidative stress in a rodent model of traumatic brain injury. J Surg Res, 186(1), 328-37 (2014)
- [25] P. R. Kumar, M. M. Essa, S. Al-Adawi, G. Dradekh, M. A. Memon, M. Akbar and T. Manivasagam: Omega-3 Fatty acids could alleviate the risks of traumatic brain injury - a mini review. J Tradit Complement Med, 4(2), 89-92 (2014)
- [26] D. C. Costa, N. Alva, L. Trigueros, A. Gamez, T. Carbonell and R. Rama: Intermittent hypobaric hypoxia induces neuroprotection in kainate-induced oxidative stress in rats. J Mol Neurosci, 50(3), 402-10 (2013)
- [27] L. Dong, S. Zhou, X. Yang, Q. Chen, Y. He and W. Huang: Magnolol protects against oxidative stress-mediated neural cell damage by modulating mitochondrial dysfunction and PI3K/Akt signaling. J Mol Neurosci, 50(3), 469-81 (2013)
- [28] M. B. Gomes and C. A. Negrato: Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases. Diabetol Metab Syndr, 6(1), 80 (2014)
- [29] K. Maiese, Z. Z. Chong, J. Hou and Y. C. Shang: Oxidative stress: Biomarkers and novel therapeutic pathways. Exp Gerontol, 45(3), 217-34 (2010)
- [30] J. Mehla, M. Pahuja, P. Gupta, S. Dethe, A. Agarwal and Y. K. Gupta: Clitoria ternatea ameliorated the intracerebroventricularly injected streptozotocin induced cognitive impairment in rats: behavioral and biochemical evidence. Psychopharmacology (Berl), 230(4), 589-605 (2013)
- [31] M. B. Nejm, A. A. Haidar, M. J. Marques, A. E. Hirata, F. N. Nogueira, E. A. Cavalheiro, F. A. Scorza and R. M. Cysneiros: Fish oil provides protection against the oxidative stress in pilocarpine model of epilepsy. Metab Brain Dis (2015)
- [32] D. Radak, I. Resanovic and E. R. Isenovic: Link Between Oxidative Stress and Acute Brain Ischemia. Angiology (2013)
- [33] A. Uzdensky, E. Berezhnaya, A. Khaitin, V. Kovaleva, M. Komandirov, M. Neginskaya, M. Rudkovskii and S. Sharifulina: Protection of the Crayfish Mechanoreceptor Neuron and Glial Cells from Photooxidative Injury by Modulators of Diverse Signal Transduction Pathways. Mol Neurobiol (2015)
- [34] Y. J. Xin, B. Yuan, B. Yu, Y. Q. Wang, J. J. Wu, W. H. Zhou and Z. Qiu: Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress. Sci Rep, 5, 7645 (2015)
- [35] M. Bajda, N. Guzior, M. Ignasik and B. Malawska: Multi-target-directed ligands in Alzheimer’s disease treatment. Curr Med Chem, 18(32), 4949-75 (2011)
- [36] Y. Y. Cao, L. Wang, H. Ge, X. L. Lu, Z. Pei, Q. Gu and J. Xu: Salvianolic acid A, a polyphenolic derivative from Salvia miltiorrhiza bunge, as a multifunctional agent for the treatment of Alzheimer’s disease. Mol Divers, 17(3), 515-24 (2013)
- [37] V. Exil, L. Ping, Y. Yu, S. Chakraborty, S. W. Caito, K. S. Wells, P. Karki, E. Lee and M. Aschner: Activation of MAPK and FoxO by manganese (Mn) in rat neonatal primary astrocyte cultures. PLoS One, 9(5), e94753 (2014)
- [38] P. Grammas, D. Tripathy, A. Sanchez, X. Yin and J. Luo: Brain microvasculature and hypoxia-related proteins in Alzheimer’s disease. Int J Clin Exp Pathol, 4(6), 616-27 (2011)
- [39] S. L. Sensi, P. Paoletti, J. Y. Koh, E. Aizenman, A. I. Bush and M. Hershfinkel: The Neurophysiology and Pathology of Brain Zinc. J Neurosci, 31(45), 16076-16085 (2011)
- [40] M. M. Aranha, D. M. Santos, S. Sola, C. J. Steer and C. M. Rodrigues: miR-34a regulates mouse neural stem cell differentiation. PLoS One, 6(8), e21396 (2011)
- [41] Z. Z. Chong, Y. C. Shang, S. Wang and K. Maiese: SIRT1: New avenues of discovery for disorders of oxidative stress. Expert Opin Ther Targets, 16(2), 167-78 (2012)
- [42] W. Duan: Targeting sirtuin-1 in Huntington’s disease: rationale and current status. CNS Drugs, 27(5), 345-52 (2013)
- [43] J. Li, L. Feng, Y. Xing, Y. Wang, L. Du, C. Xu, J. Cao, Q. Wang, S. Fan, Q. Liu and F. Fan: Radioprotective and antioxidant effect of resveratrol in hippocampus by activating sirt1. Int J Mol Sci, 15(4), 5928-39 (2014)
- [44] D. J. Liu, D. Hammer, D. Komlos, K. Y. Chen, B. L. Firestein and A. Y. Liu: SIRT1 knockdown promotes neural differentiation and attenuates the heat shock response. J Cell Physiol, 229(9), 1224-35 (2014)
- [45] S. Saharan, D. J. Jhaveri and P. F. Bartlett: SIRT1 regulates the neurogenic potential of neural precursors in the adult subventricular zone and hippocampus. J Neurosci Res, 91(5), 642-59 (2013)
- [46] Q. Sun, N. Jia, W. Wang, H. Jin, J. Xu and H. Hu: Activation of SIRT1 by curcumin blocks the neurotoxicity of amyloid-beta25-35 in rat cortical neurons. Biochem Biophys Res Commun, 448(1), 89-94 (2014)
- [47] S. Wang, Z. Z. Chong, Y. C. Shang and K. Maiese: WISP1 neuroprotection requires FoxO3a post-translational modulation with autoregulatory control of SIRT1. Curr Neurovasc Res, 10(1), 54-60 (2013)
- [48] H. Xiong, M. Dai, Y. Ou, J. Pang, H. Yang, Q. Huang, S. Chen, Z. Zhang, Y. Xu, Y. Cai, M. Liang, X. Zhang, L. Lai and Y. Zheng: SIRT1 expression in the cochlea and auditory cortex of a mouse model of age-related hearing loss. Exp Gerontol, 51, 8-14 (2014)
- [49] C. Canto, A. A. Sauve and P. Bai: Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes. Mol Aspects Med, 34(6), 1168-201 (2013)
- [50] Z. Z. Chong, S. H. Lin, F. Li and K. Maiese: The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through Akt, Bad, PARP, and mitochondrial associated “anti-apoptotic” pathways. Curr Neurovasc Res, 2(4), 271-85 (2005)
- [51] I. K. Kim, K. J. Lee, S. Rhee, S. B. Seo and J. H. Pak: Protective effects of peroxiredoxin 6 overexpression on amyloid beta-induced apoptosis in PC12 cells. Free Radic Res, 47(10), 836-46 (2013)
- [52] S. H. Kwon, S. I. Hong, S. X. Ma, S. Y. Lee and C. G. Jang: 3’,4’,7-trihydroxyflavone prevents apoptotic cell death in neuronal cells from hydrogen peroxide-induced oxidative stress. Food Chem Toxicol (2015)
- [53] K. Maiese and Z. Z. Chong: Nicotinamide: necessary nutrient emerges as a novel cytoprotectant for the brain. Trends Pharmacol Sci, 24 (5), 228-32 (2003)
- [54] K. Maiese, Z. Z. Chong, J. Hou and Y. C. Shang: The vitamin nicotinamide: translating nutrition into clinical care. Molecules, 14(9), 3446-85 (2009)
- [55] L. L. Pan, X. H. Liu, Y. L. Jia, D. Wu, Q. H. Xiong, Q. H. Gong, Y. Wang and Y. Z. Zhu: A novel compound derived from danshensu inhibits apoptosis via upregulation of heme oxygenase-1 expression in SH-SY5Y cells. Biochim Biophys Acta, 1830(4), 2861-71 (2013)
- [56] R. Pan, C. Chen, W. L. Liu and K. J. Liu: Zinc promotes the death of hypoxic astrocytes by upregulating hypoxia-induced hypoxia-inducible factor-1alpha expression via poly(ADP-ribose) polymerase-1. CNS Neurosci Ther, 19(7), 511-20 (2013)
- [57] C. S. Siegel and L. D. McCullough: NAD+ and nicotinamide: sex differences in cerebral ischemia. Neuroscience, 237, 223-31 (2013)
- [58] E. Turunc Bayrakdar, G. Armagan, Y. Uyanikgil, L. Kanit, E. Koylu and A. Yalcin: Ex vivo protective effects of nicotinamide and 3-aminobenzamide on rat synaptosomes treated with Abeta(1-42). Cell Biochem Funct (2014)
- [59] E. Turunc Bayrakdar, Y. Uyanikgil, L. Kanit, E. Koylu and A. Yalcin: Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Abeta(1-42)-induced rat model of Alzheimer’s disease. Free Radic Res, 48(2), 146-58 (2014)
- [60] T. Chen, L. Zhang, Y. Qu, K. Huo, X. Jiang and Z. Fei: The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med, 29(4), 630-6 (2012)
- [61] Z. Z. Chong, J. Kang, F. Li and K. Maiese: mGluRI Targets Microglial Activation and Selectively Prevents Neuronal Cell Engulfment Through Akt and Caspase Dependent Pathways. Curr Neurovasc Res, 2(3), 197-211 (2005)
- [62] Z. Z. Chong, F. Li and K. Maiese: GroupI Metabotropic Receptor Neuroprotection Requires Akt and Its Substrates that Govern FOXO3a, Bim, and beta-Catenin During Oxidative Stress. Curr Neurovasc Res, 3(2), 107-17 (2006)
- [63] S. Dolan, M. D. Gunn, C. Crossan and A. M. Nolan: Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep. Behav Pharmacol, 22(5-6), 582-8 (2011)
- [64] H. Domin, K. Golembiowska, D. Jantas, K. Kaminska, B. Zieba and M. Smialowska: GroupIII mGlu Receptor Agonist, ACPT-I, Exerts Potential Neuroprotective Effects In vitro and In vivo. Neurotox Res (2014)
- [65] H. Domin, D. Jantas and M. Smialowska: Neuroprotective effects of the allosteric agonist of metabotropic glutamate receptor 7 AMN082 on oxygen-glucose deprivation-and kainate-induced neuronal cell death. Neurochem Int (2015)
- [66] D. Jantas, A. Greda, S. Golda, M. Korostynski, B. Grygier, A. Roman, A. Pilc and W. Lason: Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: the impact of cell differentiation state. Neuropharmacology, 83, 36-53 (2014)
- [67] S. H. Lin and K. Maiese: The metabotropic glutamate receptor system protects against ischemic free radical programmed cell death in rat brain endothelial cells. J Cereb Blood Flow Metab, 21(3), 262-75. (2001)
- [68] K. Maiese, Z. Z. Chong, Y. C. Shang and J. Hou: Therapeutic promise and principles: Metabotropic glutamate receptors. Oxid Med Cell Longev, 1(1), 1-14 (2008)
- [69] K. Maiese, A. Vincent, S. H. Lin and T. Shaw: Group I and Group III metabotropic glutamate receptor subtypes provide enhanced neuroprotection. J Neurosci Res, 62(2), 257-272 (2000)
- [70] S. Nasrniya and M. R. Bigdeli: Ischemic tolerance induced by normobaric hyperoxia and evaluation of group I and II metabotropic glutamate receptors. Curr Neurovasc Res, 10(1), 21-8 (2013)
- [71] W. Y. Wang, H. Wang, Y. Luo, L. J. Jia, J. N. Zhao, H. H. Zhang, Z. W. Ma, Q. S. Xue and B. W. Yu: The effects of metabotropic glutamate receptor 7 allosteric agonist N,N’-dibenzhydrylethane-1,2-diamine dihydrochloride on developmental sevoflurane neurotoxicity: role of extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase signaling pathway. Neuroscience, 205, 167-77 (2012)
- [72] C. J. Williams and D. T. Dexter: Neuroprotective and symptomatic effects of targeting group III mGlu receptors in neurodegenerative disease. J Neurochem, 129(1), 4-20 (2014)
- [73] I. Aksu, M. Ates, B. Baykara, M. Kiray, A. R. Sisman, E. Buyuk, B. Baykara, C. Cetinkaya, H. Gumus and N. Uysal: Anxiety correlates to decreased blood and prefrontal cortex IGF-1 levels in streptozotocin induced diabetes. Neurosci Lett, 531(2), 176-81 (2012)
- [74] S. Cardoso, R. X. Santos, S. C. Correia, C. Carvalho, M. S. Santos, I. Baldeiras, C. R. Oliveira and P. I. Moreira: Insulin-induced recurrent hypoglycemia exacerbates diabetic brain mitochondrial dysfunction and oxidative imbalance. Neurobiol Dis, 49C, 1-12 (2012)
- [75] D. Kapogiannis, A. Boxer, J. B. Schwartz, E. L. Abner, A. Biragyn, U. Masharani, L. Frassetto, R. C. Petersen, B. L. Miller and E. J. Goetzl: Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer’s disease. FASEB J (2014)
- [76] K. Maiese, Z. Z. Chong, Y. C. Shang and S. Wang: Novel directions for diabetes mellitus drug discovery. Expert Opin Drug Discov, 8(1), 35-48 (2013)
- [77] X. Y. Mao, D. F. Cao, X. Li, J. Y. Yin, Z. B. Wang, Y. Zhang, C. X. Mao, H. H. Zhou and Z. Q. Liu: Huperzine A ameliorates cognitive deficits in streptozotocin-induced diabetic rats. Int J Mol Sci, 15(5), 7667-83 (2014)
- [78] Z. Zhao, G. Huang, B. Wang and Y. Zhong: Inhibition of NF-kappaB activation by Pyrrolidine dithiocarbamate partially attenuates hippocampal MMP-9 activation and improves cognitive deficits in streptozotocin-induced diabetic rats. Behav Brain Res, 238, 44-7 (2013)
- [79] A. Alttoa, K. Koiv, T. A. Hinsley, A. Brass and J. Harro: Differential gene expression in a rat model of depression based on persistent differences in exploratory activity. Eur Neuropsychopharmacol, 20(5), 288-300 (2010)
- [80] A. O. Estevez, K. L. Morgan, N. J. Szewczyk, D. Gems and M. Estevez: The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans. Neurotoxicology, 41, 28-43 (2014)
- [81] R. Lakhani, K. R. Vogel, A. Till, J. Liu, S. F. Burnett, K. M. Gibson and S. Subramani: Defects in GABA metabolism affect selective autophagy pathways and are alleviated by mTOR inhibition. EMBO Mol Med (2014)
- [82] S. Semaan, J. Wu, Y. Gan, Y. Jin, G. H. Li, J. F. Kerrigan, Y. C. Chang and Y. Huang: Hyperactivation of BDNF-TrkB Signaling Cascades in Human Hypothalamic Hamartoma (HH): A Potential Mechanism Contributing to Epileptogenesis. CNS Neurosci Ther (2014)
- [83] K. Y. Yoo, S. H. Kwon, C. H. Lee, B. Yan, J. H. Park, J. H. Ahn, J. H. Choi, T. G. Ohk, J. H. Cho and M. H. Won: FoxO3a changes in pyramidal neurons and expresses in non-pyramidal neurons and astrocytes in the gerbil hippocampal CA1 region after transient cerebral ischemia. Neurochem Res, 37(3), 588-95 (2012)
- [84] P. K. Bahia, V. Pugh, K. Hoyland, V. Hensley, M. Rattray and R. J. Williams: Neuroprotective effects of phenolic antioxidant tBHQ associate with inhibition of FoxO3a nuclear translocation and activity. J Neurochem, 123(1), 182-91 (2012)
- [85] J. Chen, H. Mao, H. Zou, W. Jin, L. Ni, K. Ke, M. Cao and W. Shi: Up-regulation of ski-interacting protein in rat brain cortex after traumatic brain injury. J Mol Histol, 44(1), 1-10 (2013)
- [86] Z. Z. Chong, S. H. Lin and K. Maiese: The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential. J Cereb Blood Flow Metab, 24(7), 728-43 (2004)
- [87] M. De Butte-Smith, R. S. Zukin and A. M. Etgen: Effects of global ischemia and estradiol pretreatment on phosphorylation of Akt, CREB and STAT3 in hippocampal CA1 of young and middle-aged female rats. Brain Res, 1471, 118-28 (2012)
- [88] A. Domanskyi, H. Alter, M. A. Vogt, P. Gass and I. A. Vinnikov: Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance. Front Cell Neurosci, 8, 275 (2014)
- [89] E. C. Genin, N. Caron, R. Vandenbosch, L. Nguyen and B. Malgrange: Concise review: forkhead pathway in the control of adult neurogenesis. Stem Cells, 32(6), 1398-407 (2014)
- [90] F. Gilels, S. T. Paquette, J. Zhang, I. Rahman and P. M. White: Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice. J Neurosci, 33(47), 18409-24 (2013)
- [91] F. Li, Z. Z. Chong and K. Maiese: Navigating novel mechanisms of cellular plasticity with the NAD+ precursor and nutrient nicotinamide. Front Biosci, 9, 2500-2520 (2004)
- [92] W. Liu, X. Liu, H. Yang, X. Zhu, H. Yi, X. Zhu and J. Zhang: Phosphorylated retinoblastoma protein (p-Rb) is involved in neuronal apoptosis after traumatic brain injury in adult rats. J Mol Histol, 44(2), 147-58 (2013)
- [93] K. Maiese: FoxO proteins in the nervous system. Anal Cell Pathol (Amst), 2015(Article ID 569392) (2015)
- [94] K. Maiese, Z. Z. Chong and Y. C. Shang: OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins. Trends Mol Med, 14(5), 219-27 (2008)
- [95] S. Peng, S. Zhao, F. Yan, J. Cheng, L. Huang, H. Chen, Q. Liu, X. Ji and Z. Yuan: HDAC2 selectively regulates FOXO3a-mediated gene transcription during oxidative stress-induced neuronal cell death. J Neurosci, 35(3), 1250-9 (2015)
- [96] M. Sertbas, K. Ulgen and T. Cakir: Systematic analysis of transcription-level effects of neurodegenerative diseases on human brain metabolism by a newly reconstructed brain-specific metabolic network. FEBS Open Bio, 4, 542-53 (2014)
- [97] T. Tanaka and M. Iino: Knockdown of Sec8 promotes cell-cycle arrest at G/S phase by inducing p21 via control of FOXO proteins. FEBS J (2013)
- [98] Q. Xie, Y. Hao, L. Tao, S. Peng, C. Rao, H. Chen, H. You, M. Q. Dong and Z. Yuan: Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death. EMBO Rep, 13(4), 371-377 (2012)
- [99] E. Zeldich, C. D. Chen, T. A. Colvin, E. A. Bove-Fenderson, J. Liang, T. B. Tucker Zhou, D. A. Harris and C. R. Abraham: The neuroprotective effect of Klotho is mediated via regulation of members of the redox system. J Biol Chem, 289(35), 24700-15 (2014)
- [100] M. Albiero, N. Poncina, M. Tjwa, S. Ciciliot, L. Menegazzo, G. Ceolotto, S. Vigili de Kreutzenberg, R. Moura, M. Giorgio, P. Pelicci, A. Avogaro and G. P. Fadini: Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and Sirt1. Diabetes, 63(4), 1353-65 (2014)
- [101] D. Angelis, T. D. Fontanez-Nieves and M. Delivoria-Papadopoulos: The Role of Src Kinase in the Caspase-1 Pathway After Hypoxia in the Brain of Newborn Piglets. Neurochem Res (2014)
- [102] Z. Z. Chong, S. H. Lin, J. Q. Kang and K. Maiese: The tyrosine phosphatase SHP2 modulates MAP kinase p38 and caspase 1 and 3 to foster neuronal survival. Cell Mol Neurobiol, 23(4-5), 561-78 (2003)
- [103] Z. Z. Chong and K. Maiese: The Src homology 2 domain tyrosine phosphatases SHP-1 and SHP-2: diversified control of cell growth, inflammation, and injury. Histol Histopathol, 22(11), 1251-67 (2007)
- [104] Y. S. Huang, C. Y. Cheng, S. H. Chueh, D. Y. Hueng, Y. F. Huang, C. M. Chu, S. T. Wu, M. C. Tai, C. M. Liang, M. H. Liao, C. C. Chen, L. H. Shen and K. H. Ma: Involvement of SHP2 in focal adhesion, migration and differentiation of neural stem cells. Brain Dev, 34(8), 674-84 (2012)
- [105] A. Jalsrai, T. Numakawa, Y. Ooshima, N. Adachi and H. Kunugi: Phosphatase-mediated intracellular signaling contributes to neuroprotection by flavonoids of Iris tenuifolia. Am J Chin Med, 42(1), 119-30 (2014)
- [106] A. Jo, H. Park, S. H. Lee, S. H. Ahn, H. J. Kim, E. M. Park and Y. H. Choi: SHP-2 Binds to Caveolin-1 and Regulates Src Activity via Competitive Inhibition of CSK in Response to H2O2 in Astrocytes. PLoS One, 9(3), e91582 (2014)
- [107] J. H. Yun, S. J. Park, A. Jo, J. L. Kang, I. Jou, J. S. Park and Y. H. Choi: Caveolin-1 is involved in reactive oxygen species-induced SHP-2 activation in astrocytes. Exp Mol Med, 43(12), 660-8 (2011)
- [108] J. A. Burket, A. D. Benson, A. H. Tang and S. I. Deutsch: Rapamycin improves sociability in the BTBR T(+)Itpr3(tf)/J mouse model of autism spectrum disorders. Brain Res Bull, 100, 70-5 (2014)
- [109] A. Chen, L. J. Xiong, Y. Tong and M. Mao: Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3K/Akt/mTOR pathway. Mol Med Rep, 8(4), 1011-6 (2013)
- [110] A. Francois, A. Rioux-Bilan, N. Quellard, B. Fernandez, T. Janet, D. Chassaing, M. Paccalin, F. Terro and G. Page: Longitudinal follow-up of autophagy and inflammation in brain of APPswePS1dE9 transgenic mice. J Neuroinflammation, 11(1), 139 (2014)
- [111] C. Gubern, S. Camos, O. Hurtado, R. Rodriguez, V. G. Romera, M. Sobrado, R. Canadas, M. A. Moro, I. Lizasoain, J. Serena, J. Mallolas and M. Castellanos: Characterization of Gcf2/Lrrfip1 in experimental cerebral ischemia and its role as a modulator of Akt, mTOR and beta-catenin signaling pathways. Neuroscience, 268C, 48-65 (2014)
- [112] M. Hadamitzky, A. Herring, K. Keyvani, R. Doenlen, U. Krugel, K. Bosche, K. Orlowski, H. Engler and M. Schedlowski: Acute systemic rapamycin induces neurobehavioral alterations in rats. Behav Brain Res, 273, 16-22 (2014)
- [113] A. Jenwitheesuk, C. Nopparat, S. Mukda, P. Wongchitrat and P. Govitrapong: Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways. Int J Mol Sci, 15(9), 16848-84 (2014)
- [114] M. Ka, G. Condorelli, J. R. Woodgett and W. Y. Kim: mTOR regulates brain morphogenesis by mediating GSK3 signaling. Development, 141(21), 4076-86 (2014)
- [115] M. N. Kamarudin, N. A. Mohd Raflee, S. S. Syed Hussein, J. Y. Lo, H. Supriady and H. Abdul Kadir: (R)-(+)-alpha-Lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3beta pathway and suppression of NF-kappabeta-cytokines. Drug Des Devel Ther, 8, 1765-80 (2014)
- [116] K. Maiese, Z. Z. Chong, Y. C. Shang and S. Wang: mTOR: on target for novel therapeutic strategies in the nervous system. Trends Mol Med, 19(1), 51-60 (2013)
- [117] H. E. Moon, K. Byun, H. W. Park, J. H. Kim, J. Hur, J. S. Park, J. K. Jun, H. S. Kim, S. L. Paek, I. K. Kim, J. H. Hwang, J. W. Kim, D. G. Kim, Y. C. Sung, G. Y. Koh, C. W. Song, B. Lee and S. H. Paek: COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway. Exp Neurobiol, 24(1), 55-70 (2015)
- [118] J. Romine, X. Gao, X. M. Xu, K. F. So and J. Chen: The proliferation of amplifying neural progenitor cells is impaired in the aging brain and restored by the mTOR pathway activation. Neurobiol Aging, 36(4), 1716-26 (2015)
- [119] N. S. Rozas, J. B. Redell, J. McKenna, 3rd, A. N. Moore, M. J. Gambello and P. K. Dash: Prolonging the survival of Tsc2 conditional knockout mice by glutamine supplementation. Biochem Biophys Res Commun, 457(4), 635-9 (2015)
- [120] X. Zhong, R. Lin, Z. Li, J. Mao and L. Chen: Effects of Salidroside on Cobalt Chloride-Induced Hypoxia Damage and mTOR Signaling Repression in PC12 Cells. Biol Pharm Bull, 37(7), 1199-206 (2014)
- [121] S. Lanfranconi, F. Locatelli, S. Corti, L. Candelise, G. P. Comi, P. L. Baron, S. Strazzer, N. Bresolin and A. Bersano: Growth factors in ischemic stroke. J Cell Mol Med, 15(8), 1645-87 (2011)
- [122] K. Maiese: Programming apoptosis and autophagy with novel approaches for diabetes mellitus. Curr Neurovasc Res, 12(2), 173-88 (2015)
- [123] K. Maiese and L. Boccone: Neuroprotection by peptide growth factors against anoxia and nitric oxide toxicity requires modulation of protein kinase C. J Cereb Blood Flow Metab, 15(3), 440-9 (1995)
- [124] D. Mittal, A. Ali, S. Md, S. Baboota, J. K. Sahni and J. Ali: Insights into direct nose to brain delivery: current status and future perspective. Drug Deliv, 21(2), 75-86 (2014)
- [125] S. S. Newton, N. M. Fournier and R. S. Duman: Vascular growth factors in neuropsychiatry.Cell Mol Life Sci, 70(10), 1739-52 (2013)
- [126] K. Maiese, F. Li and Z. Z. Chong: New avenues of exploration for erythropoietin. Jama, 293(1), 90-5 (2005)
- [127] N. Imai, A. Kawamura, M. Higuchi, M. Oh-eda, T. Orita, T. Kawaguchi and N. Ochi: Physicochemical and biological comparison of recombinant human erythropoietin with human urinary erythropoietin. J Biochem (Tokyo), 107(3), 352-9. (1990)
- [128] R. Castaneda-Arellano, C. Beas-Zarate, A. I. Feria-Velasco, E. W. Bitar-Alatorre and M. C. Rivera-Cervantes: From neurogenesis to neuroprotection in the epilepsy: signalling by erythropoietin. Front Biosci (Landmark Ed), 19, 1445-55 (2014)
- [129] K. Maiese, Z. Z. Chong and Y. C. Shang: Raves and risks for erythropoietin. Cytokine Growth Factor Rev, 19(2), 145-155 (2008)
- [130] L. Wang, L. Di and C. T. Noguchi: Erythropoietin, a novel versatile player regulating energy metabolism beyond the erythroid system. Int J Biol Sci, 10(8), 921-39 (2014)
- [131] Y. Zhang, L. Wang, S. Dey, M. Alnaeeli, S. Suresh, H. Rogers, R. Teng and C. T. Noguchi: Erythropoietin action in stress response, tissue maintenance and metabolism. Int J Mol Sci, 15(6), 10296-333 (2014)
- [132] K. Maiese, Z. Z. Chong, Y. C. Shang and S. Wang: Erythropoietin: new directions for the nervous system. Int J Mol Sci, 13(9), 11102-29 (2012)
- [133] K. Maiese, Z. Z. Chong, F. Li and Y. C. Shang: Erythropoietin: elucidating new cellular targets that broaden therapeutic strategies. Prog Neurobiol, 85(2), 194-213 (2008)
- [134] C. Bernard: Remarques sur le sécrétion du sucre dans la foie, faites à l’occasion de la communication de M Lehman. Comptes rendus Academies de Sciences, 40, 589-592 (1855)
- [135] P. Carnot and C. DeFlandre: Sur l’activite hemopoietique de serum au cours de la regeneration du sang. C R Acad Sci (Paris) 143, 384-386 (1906)
- [136] A. J. Erslev: In vitro production of erythropoietin by kidneys perfused with a serum-free solution. Blood, 44(1), 77-85 (1974)
- [137] C. Gibelli: Uber den wert des serums anamisch gemachten tiere bei der regeneration des blutes. Arch Exp Pathol Pharmacol, 65, 284-302 (1911)
- [138] G. Sandor: Uber die blutbidende wirkung des serums von tieren, die in verdunnter luft gehalten wuren. Z Gesante Exp Med, 82, 633-646 (1932)
- [139] K. Jacobs, C. Shoemaker, R. Rudersdorf, S. D. Neill, R. J. Kaufman, A. Mufson, J. Seehra, S. S. Jones, R. Hewick, E. F. Fritsch, M. Kawakita, T. Shimizu and T. Miyake: Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature, 313(6005), 806-10. (1985)
- [140] F. K. Lin, S. Suggs, C. H. Lin, J. K. Browne, R. Smalling, J. C. Egrie, K. K. Chen, G. M. Fox, F. Martin, Z. Stabinsky, S. Badrawi, P.-H. Lai and E. Goldwasser: Cloning and expression of the human erythropoietin gene. Proc Natl Acad Sci U S A, 82(22), 7580-4 (1985)
- [141] F. Li, Z. Z. Chong and K. Maiese: Erythropoietin on a Tightrope: Balancing Neuronal and Vascular Protection between Intrinsic and Extrinsic Pathways. Neurosignals, 13(6), 265-89 (2004)
- [142] A. Palazzuoli, G. Ruocco, M. Pellegrini, C. De Gori, G. Del Castillo, N. Giordano and R. Nuti: The role of erythropoietin stimulating agents in anemic patients with heart failure: solved and unresolved questions. Ther Clin Risk Manag, 10, 641-50 (2014)
- [143] E. M. Moore, R. Bellomo and A. D. Nichol: Erythropoietin as a novel brain and kidney protective agent. Anaesth Intensive Care, 39(3), 356-72 (2011)
- [144] C. Caprara and C. Grimm: From oxygen to erythropoietin: relevance of hypoxia for retinal development, health and disease. Prog Retin Eye Res, 31(1), 89-119 (2012)
- [145] Z. Z. Chong, J. Q. Kang and K. Maiese: Angiogenesis and plasticity: role of erythropoietin in vascular systems.J Hematother Stem Cell Res, 11(6), 863-71 (2002)
- [146] S. Kato, M. Aoyama, H. Kakita, H. Hida, I. Kato, T. Ito, T. Goto, M. H. Hussein, K. Sawamoto, H. Togari and K. Asai: Endogenous erythropoietin from astrocyte protects the oligodendrocyte precursor cell against hypoxic and reoxygenation injury. J Neurosci Res, 89(10), 1566-74 (2011)
- [147] K. Maiese, F. Li and Z. Z. Chong: Erythropoietin in the brain: can the promise to protect be fulfilled? Trends Pharmacol Sci, 25(11), 577-583 (2004)
- [148] S. B. Krantz: Erythropoietin. Blood, 77(3), 419-34. (1991)
- [149] K. Maiese, Z. Z. Chong, J. Hou and Y. C. Shang: Erythropoietin and oxidative stress. Curr Neurovasc Res, 5(2), 125-42 (2008)
- [150] E. Tsuda, G. Kawanishi, M. Ueda, S. Masuda and R. Sasaki: The role of carbohydrate in recombinant human erythropoietin. Eur J Biochem, 188(2), 405-11. (1990)
- [151] E. Uchida, K. Morimoto, N. Kawasaki, Y. Izaki, A. Abdu Said and T. Hayakawa: Effect of active oxygen radicals on protein and carbohydrate moieties of recombinant human erythropoietin. Free Radic Res, 27(3), 311-23. (1997)
- [152] T. Toyoda, T. Itai, T. Arakawa, K. H. Aoki and H. Yamaguchi: Stabilization of human recombinant erythropoietin through interactions with the highly branched N-glycans. J Biochem (Tokyo), 128(5), 731-7. (2000)
- [153] F. F. Wang, C. K. Kung and E. Goldwasser: Some chemical properties of human erythropoietin. Endocrinology, 116(6), 2286-92. (1985)
- [154] K. Reissmann: Studies on the mechanism of erythropoietin stimulation in parabiotic rats during hypoxia. Blood, 5, 347-380 (1950)
- [155] K. Maiese: Triple play: Promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus. Biomed Pharmacother, 62(4), 218-232 (2008)
- [156] K. Maiese: Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease. Neural Regen Res, 10(4), 518-528 (2015)
- [157] A. Guven Bagla, E. Ercan, H. F. Asgun, M. Ickin, F. Ercan, O. Yavuz, S. Bagla and A. Kaplan: Experimental acute myocardial infarction in rats: HIF-1alpha, caspase-3, erythropoietin and erythropoietin receptor expression and the cardioprotective effects of two different erythropoietin doses. Acta Histochem, 115(7), 658-68 (2013)
- [158] K. Nishimura, M. Tokida, H. Katsuyama, H. Nakagawa and S. Matsuo: The effect of hemin-induced oxidative stress on erythropoietin production in HepG2 cells. Cell Biol Int (2014)
- [159] A. A. Ali, J. A. Coulter, C. H. Ogle, M. M. Migaud, D. G. Hirst, T. Robson and H. O. McCarthy: The contribution of N(2)O(3) to the cytotoxicity of the nitric oxide donor DETA/NO: an emerging role for S-nitrosylation. Biosci Rep, 33(2) (2013)
- [160] A. Deng, M. A. Arndt, J. Satriano, P. Singh, T. Rieg, S. Thomson, T. Tang and R. C. Blantz: Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade. Am J Physiol Renal Physiol, 299(6), F1365-73 (2010)
- [161] N. Singh, G. Sharma, V. Mishra and R. Raghubir: Hypoxia Inducible Factor-1: Its Potential Role In Cerebral Ischemia. Cell Mol Neurobiol (2012)
- [162] K. Teramo, M. A. Kari, M. Eronen, H. Markkanen and V. Hiilesmaa: High amniotic fluid erythropoietin levels are associated with an increased frequency of fetal and neonatal morbidity in type 1 diabetic pregnancies. Diabetologia, 47(10), 1695-703 (2004)
- [163] S. J. Korzeniewski, E. Allred, J. W. Logan, R. N. Fichorova, S. Engelke, K. C. Kuban, T. M. O’Shea, N. Paneth, M. Holm, O. Dammann and A. Leviton: Elevated endogenous erythropoietin concentrations are associated with increased risk of brain damage in extremely preterm neonates. PLoS One, 10(3), e0115083 (2015)
- [164] S. Masuda, M. Chikuma and R. Sasaki: Insulin-like growth factors and insulin stimulate erythropoietin production in primary cultured astrocytes. Brain Res, 746(1-2), 63-70 (1997)
- [165] A. Symeonidis, A. Kouraklis-Symeonidis, A. Psiroyiannis, M. Leotsinidis, V. Kyriazopoulou, P. Vassilakos, A. Vagenakis and N. Zoumbos: Inappropriately low erythropoietin response for the degree of anemia in patients with noninsulin-dependent diabetes mellitus. Ann Hematol, 85(2), 79-85 (2006)
- [166] C. F. Tsai, Y. H. Kuo, W. L. Yeh, C. Y. Wu, H. Y. Lin, S. W. Lai, Y. S. Liu, L. H. Wu, J. K. Lu and D. Y. Lu: Regulatory Effects of Caffeic Acid Phenethyl Ester on Neuroinflammation in Microglial Cells. Int J Mol Sci, 16(3), 5572-5589 (2015)
- [167] N. Diez-Padrisa, R. Aguilar, S. Machevo, L. Morais, T. Nhampossa, C. O’Callaghan-Gordo, D. Nhalungo, C. Menendez, A. Roca, P. L. Alonso and Q. Bassat: Erythropoietin levels are not independently associated with malaria-attributable severe disease in mozambican children. PLoS ONE, 6(8), e24090 (2011)
- [168] C. Stoppe, M. Coburn, A. Fahlenkamp, J. Ney, S. Kraemer, R. Rossaint and A. Goetzenich: Elevated serum concentrations of erythropoietin after xenon anaesthesia in cardiac surgery: secondary analysis of a randomized controlled trial. Br J Anaesth, 114 (4), 701-3 (2015)
- [169] N. Kaushal, S. Hegde, J. Lumadue, R. F. Paulson and K. S. Prabhu: The regulation of erythropoiesis by selenium in mice. Antioxid Redox Signal, 14(8), 1403-12 (2011)
- [170] Z. Z. Chong, J. Q. Kang and K. Maiese: Erythropoietin: cytoprotection in vascular and neuronal cells. Curr Drug Targets Cardiovasc Haematol Disord, 3(2), 141-54 (2003)
- [171] C. L. Li, J. Jiang, Y. Q. Fan, G. S. Fu, J. A. Wang and W. M. Fan: Knockout of the tumor necrosis factor a receptor 1 gene can up-regulate erythropoietin receptor during myocardial ischemia-reperfusion injury in mice. Chin Med J (Engl), 122(5), 566-70 (2009)
- [172] Z. Z. Chong, J. Q. Kang and K. Maiese: Hematopoietic factor erythropoietin fosters neuroprotection through novel signal transduction cascades. J Cereb Blood Flow Metab, 22(5), 503-14 (2002)
- [173] Z. Z. Chong, F. Li and K. Maiese: Activating Akt and the brain’s resources to drive cellular survival and prevent inflammatory injury. Histol Histopathol, 20(1), 299-315 (2005)
- [174] Z. Z. Chong, Y. C. Shang, S. Wang and K. Maiese: ACritical Kinase Cascade in Neurological Disorders: PI 3-K, Akt, and mTOR. Future Neurol, 7(6), 733-748 (2012)
- [175] Y. Fong, Y. C. Lin, C. Y. Wu, H. M. Wang, L. L. Lin, H. L. Chou, Y. N. Teng, S. S. Yuan and C. C. Chiu: The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/beta-catenin-Foxo3a axis. ScientificWorldJournal, 2014, 937051 (2014)
- [176] S. Al Sweidi, M. G. Sanchez, M. Bourque, M. Morissette, D. Dluzen and T. Di Paolo: Oestrogen receptors and signalling pathways: implications for neuroprotective effects of sex steroids in Parkinson’s disease. J Neuroendocrinol, 24(1), 48-61 (2012)
- [177] K. K. Ambacher, K. B. Pitzul, M. Karajgikar, A. Hamilton, S. S. Ferguson and S. P. Cregan: The JNK-and AKT/GSK3beta-Signaling Pathways Converge to Regulate Puma Induction and Neuronal Apoptosis Induced by Trophic Factor Deprivation. PLoS ONE, 7(10), e46885 (2012)
- [178] R. M. Uranga, S. Katz and G. A. Salvador: Enhanced phosphatidylinositol 3-kinase (PI3K)/Akt signaling has pleiotropic targets in hippocampal neurons exposed to iron-induced oxidative stress. J Biol Chem, 288 (27), 19773-84 (2013)
- [179] X. Zhou, L. Wang, M. Wang, L. Xu, L. Yu, T. Fang and M. Wu: Emodin-induced microglial apoptosis is associated with TRB3 induction. Immunopharmacol Immunotoxicol, 33(4), 594-602 (2011)
- [180] J. Branchu, O. Biondi, F. Chali, T. Collin, F. Leroy, K. Mamchaoui, J. Makoukji, C. Pariset, P. Lopes, C. Massaad, C. Chanoine and F. Charbonnier: Shift from extracellular signal-regulated kinase to AKT/cAMP response element-binding protein pathway increases survival-motor-neuron expression in spinal-muscular-atrophy-like mice and patient cells. J Neurosci, 33(10), 4280-94 (2013)
- [181] B. Chen, J. A. Van Winkle, P. D. Lyden, J. H. Brown and N. H. Purcell: PHLPP1 gene deletion protects the brain from ischemic injury. J Cereb Blood Flow Metab, 33(2), 196-204 (2013)
- [182] L. Bing, J. Wu, J. Zhang, Y. Chen, Z. Hong and H. Zu: DHT Inhibits the Abeta25-35-Induced Apoptosis by Regulation of Seladin-1, Survivin, XIAP, bax, and bcl-xl Expression Through a Rapid PI3-K/Akt Signaling in C6 Glial Cell Lines. Neurochem Res (2014)
- [183] Z. Z. Chong, F. Li and K. Maiese: Cellular demise and inflammatory microglial activation during beta-amyloid toxicity are governed by Wnt1 and canonical signaling pathways. Cell Signal, 19(6), 1150-62 (2007)
- [184] V. Echeverria, R. Zeitlin, S. Burgess, S. Patel, A. Barman, G. Thakur, M. Mamcarz, L. Wang, D. B. Sattelle, D. A. Kirschner, T. Mori, R. M. Leblanc, R. Prabhakar and G. W. Arendash: Cotinine Reduces Amyloid-beta Aggregation and Improves Memory in Alzheimer’s Disease Mice. J Alzheimers Dis (2011)
- [185] J. Liang, L. Liu and D. Xing: Photobiomodulation by low-power laser irradiation attenuates Abeta-induced cell apoptosis through the Akt/GSK3beta/beta-catenin pathway. Free Radic Biol Med, 53(7), 1459-67 (2012)
- [186] Y. C. Shang, Z. Z. Chong, S. Wang and K. Maiese: Prevention of beta-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL. Aging (Albany NY), 4(3), 187-201 (2012)
- [187] Y. C. Shang, Z. Z. Chong, S. Wang and K. Maiese: Tuberous sclerosis protein 2 (TSC2) modulates CCN4 cytoprotection during apoptotic amyloid toxicity in microglia. Curr Neurovasc Res, 10(1), 29-38 (2013)
- [188] Y. Wang, Y. X. Wang, T. Liu, P. Y. Law, H. H. Loh, Y. Qiu and H. Z. Chen: mu-Opioid Receptor Attenuates Abeta Oligomers-Induced Neurotoxicity Through mTOR Signaling. CNS Neurosci Ther (2014)
- [189] Z. Xue, Y. Guo, S. Zhang, L. Huang, Y. He, R. Fang and Y. Fang: Beta-asarone attenuates amyloid beta-induced autophagy via Akt/mTOR pathway in PC12 cells. Eur J Pharmacol, 741, 195-204 (2014)
- [190] S. Zara, M. De Colli, M. Rapino, S. Pacella, C. Nasuti, P. Sozio, A. Di Stefano and A. Cataldi: Ibuprofen and lipoic acid conjugate neuroprotective activity is mediated by Ngb/Akt intracellular signaling pathway in Alzheimer’s disease rat model. Gerontology, 59(3), 250-60 (2013)
- [191] K. W. Zeng, X. M. Wang, H. Ko, H. C. Kwon, J. W. Cha and H. O. Yang: Hyperoside protects primary rat cortical neurons from neurotoxicity induced by amyloid beta-protein via the PI3K/Akt/Bad/Bcl(XL)-regulated mitochondrial apoptotic pathway. Eur J Pharmacol, 672(1-3), 45-55 (2011)
- [192] J. Zhang, X. Feng, J. Wu, H. Xu, G. Li, D. Zhu, Q. Yue, H. Liu, Y. Zhang, D. Sun, H. Wang and J. Sun: Neuroprotective effects of resveratrol on damages of mouse cortical neurons induced by beta-amyloid through activation of SIRT1/Akt1 pathway. Biofactors, 40(2), 258-267 (2013)
- [193] Z. Zhu, J. Yan, W. Jiang, X. G. Yao, J. Chen, L. Chen, C. Li, L. Hu, H. Jiang and X. Shen: Arctigenin effectively ameliorates memory impairment in Alzheimer’s disease model mice targeting both beta-amyloid production and clearance. J Neurosci, 33(32), 13138-49 (2013)
- [194] Z. Z. Chong and K. Maiese: Erythropoietin involves the phosphatidylinositol 3-kinase pathway, 14-3-3 protein and FOXO3a nuclear trafficking to preserve endothelial cell integrity. Br J Pharmacol, 150(7), 839-50 (2007)
- [195] Y. F. Ji, L. Zhou, Y. J. Xie, S. M. Xu, J. Zhu, P. Teng, C. Y. Shao, Y. Wang, J. H. Luo and Y. Shen: Upregulation of glutamate transporter GLT-1 by mTOR-Akt-NF-small ka, CyrillicB cascade in astrocytic oxygen-glucose deprivation. Glia, 61(12), 1959-75 (2013)
- [196] F. Li, Z. Z. Chong and K. Maiese: Microglial integrity is maintained by erythropoietin through integration of Akt and its substrates of glycogen synthase kinase-3beta, beta-catenin, and nuclear factor-kappaB. Curr Neurovasc Res, 3(3), 187-201 (2006)
- [197] S. Wang, Z. Z. Chong, Y. C. Shang and K. Maiese: Wnt1 inducible signaling pathway protein 1 (WISP1) blocks neurodegeneration through phosphoinositide 3 kinase/Akt1 and apoptotic mitochondrial signaling involving Bad, Bax, Bim, and Bcl-xL. Curr Neurovasc Re s, 9 (1), 20-31 (2012)
- [198] F. Zhang, T. Ding, L. Yu, Y. Zhong, H. Dai and M. Yan: Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells. J Pharm Pharmacol, 64(1), 120-7 (2012)
- [199] Z. Z. Chong, J. Q. Kang and K. Maiese: Erythropoietin is a novel vascular protectant through activation of Akt1 and mitochondrial modulation of cysteine proteases. Circulation, 106(23), 2973-9 (2002)
- [200] Z. Rong, R. Pan, Y. Xu, C. Zhang, Y. Cao and D. Liu: Hesperidin pretreatment protects hypoxia-ischemic brain injury in neonatal rat. Neuroscience, 255, 292-9 (2013)
- [201] B. N. Seo, J. M. Ryu, S. P. Yun, J. H. Jeon, S. S. Park, K. B. Oh, J. K. Park and H. J. Han: Delphinidin prevents hypoxia-induced mouse embryonic stem cell apoptosis through reduction of intracellular reactive oxygen species-mediated activation of JNK and NF-kappaB, and Akt inhibition. Apoptosis, 18(7), 811-24 (2013)
- [202] J. Su, Y. Tang, H. Zhou, L. Liu and Q. Dong: Tissue kallikrein protects neurons from hypoxia/reoxygenation-induced cell injury through Homer1b/c. Cell Signal, 24(11), 2205-15 (2012)
- [203] S. Busch, A. Kannt, M. Kolibabka, A. Schlotterer, Q. Wang, J. Lin, Y. Feng, S. Hoffmann, N. Gretz and H. P. Hammes: Systemic treatment with erythropoietin protects the neurovascular unit in a rat model of retinal neurodegeneration. PLoS One, 9(7), e102013 (2014)
- [204] Z. Z. Chong, J. Hou, Y. C. Shang, S. Wang and K. Maiese: EPO Relies upon Novel Signaling of Wnt1 that Requires Akt1, FoxO3a, GSK-3beta, and beta-Catenin to Foster Vascular Integrity During Experimental Diabetes. Curr Neurovasc Res, 8(2), 103-20 (2011)
- [205] F. Das, N. Dey, B. Venkatesan, B. S. Kasinath, N. Ghosh-Choudhury and G. G. Choudhury: High glucose upregulation of early-onset Parkinson’s disease protein DJ-1 integrates the PRAS40/TORC1 axis to mesangial cell hypertrophy. Cell Signal, 23(8), 1311-9 (2011)
- [206] J. Hou, Z. Z. Chong, Y. C. Shang and K. Maiese: FoxO3a governs early and late apoptotic endothelial programs during elevated glucose through mitochondrial and caspase signaling. Mol Cell Endocrinol, 321(2), 194-206 (2010)
- [207] J. Hou, Z. Z. Chong, Y. C. Shang and K. Maiese: Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation. Curr Neurovasc Res, 7(2), 95-112 (2010)
- [208] R. Kimura, M. Okouchi, T. Kato, K. Imaeda, N. Okayama, K. Asai and T. Joh: Epidermal growth factor receptor transactivation is necessary for glucagon-like peptide-1 to protect PC12 cells from apoptosis. Neuroendocrinology, 97(4), 300-8 (2013)
- [209] Z. Y. Chang, M. K. Yeh, C. H. Chiang, Y. H. Chen and D. W. Lu: Erythropoietin protects adult retinal ganglion cells against NMDA-, trophic factor withdrawal-, and TNF-alpha-induced damage. PLoS One, 8(1), e55291 (2013)
- [210] Z. Z. Chong, J. Q. Kang and K. Maiese: Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase-mediated pathways. Br J Pharmacol, 138(6), 1107-1118 (2003)
- [211] M. S. Kwon, M. H. Kim, S. H. Kim, K. D. Park, S. H. Yoo, I. U. Oh, S. Pak and Y. J. Seo: Erythropoietin exerts cell protective effect by activating PI3K/Akt and MAPK pathways in C6 Cells. Neurol Res, 36(3), 215-23 (2014)
- [212] A. Parvin, R. Pranap, U. Shalini, A. Devendran, J. E. Baker and A. Dhanasekaran: Erythropoietin protects cardiomyocytes from cell death during hypoxia/reperfusion injury through activation of survival signaling pathways. PLoS One, 9(9), e107453 (2014)
- [213] Y. Yu, S. R. Shiou, Y. Guo, L. Lu, M. Westerhoff, J. Sun, E. O. Petrof and E. C. Claud: Erythropoietin protects epithelial cells from excessive autophagy and apoptosis in experimental neonatal necrotizing enterocolitis. PLoS One, 8(7), e69620 (2013)
- [214] J. Kang, J. Y. Yun, J. Hur, J. A. Kang, J. I. Choi, S. B. Ko, J. Lee, J. Y. Kim, I. C. Hwang, Y. B. Park and H. S. Kim: Erythropoietin priming improves the vasculogenic potential of G-CSF mobilized human peripheral blood mononuclear cells. Cardiovasc Res, 104(1), 171-82 (2014)
- [215] Z. Z. Chong, S. H. Lin, J. Q. Kang and K. Maiese: Erythropoietin prevents early and late neuronal demise through modulation of Akt1 and induction of caspase 1, 3, and 8. J Neurosci Res, 71(5), 659-69 (2003)
- [216] W. Fu, X. Liao, J. Ruan, X. Li, L. Chen, B. Wang, K. Wang and J. Zhou: Recombinant human erythropoietin preconditioning attenuates liver ischemia reperfusion injury through the phosphatidylinositol-3 kinase/AKT/endothelial nitric oxide synthase pathway. J Surg Res, 183(2), 876-84 (2013)
- [217] R. Ma, N. Xiong, C. Huang, Q. Tang, B. Hu, J. Xiang and G. Li: Erythropoietin protects PC12 cells from beta-amyloid(25-35)-induced apoptosis via PI3K/Akt signaling pathway. Neuropharmacology, 56(6-7), 1027-34 (2009)
- [218] T. Maurice, M. H. Mustafa, C. Desrumaux, E. Keller, G. Naert, C. G.-B. M. de la, Y. Rodriguez Cruz and J. C. Garcia Rodriguez: Intranasal formulation of erythropoietin (EPO) showed potent protective activity against amyloid toxicity in the Abeta(2)(5)(-)(3)(5) non-transgenic mouse model of Alzheimer’s disease. J Psychopharmacol, 27(11), 1044-57 (2013)
- [219] Z. K. Sun, H. Q. Yang, J. Pan, H. Zhen, Z. Q. Wang, S. D. Chen and J. Q. Ding: Protective effects of erythropoietin on tau phosphorylation induced by beta-amyloid. J Neurosci Res, 86(13), 3018-27 (2008)
- [220] Y. Bennis, G. Sarlon-Bartoli, B. Guillet, L. Lucas, L. Pellegrini, L. Velly, M. Blot-Chabaud, F. Dignat-Georges, F. Sabatier and P. Pisano: Priming of late endothelial progenitor cells with erythropoietin before transplantation requires the CD131 receptor subunit and enhances their angiogenic potential. J Thromb Haemost, 10(9), 1914-28 (2012)
- [221] J. Hou, S. Wang, Y. C. Shang, Z. Z. Chong and K. Maiese: Erythropoietin Employs Cell Longevity Pathways of SIRT1 to Foster Endothelial Vascular Integrity During Oxidant Stress. Curr Neurovasc Res, 8(3), 220-35 (2011)
- [222] A. I. Khan, S. M. Coldewey, N. S. Patel, M. Rogazzo, M. Collino, M. M. Yaqoob, P. Radermacher, A. Kapoor and C. Thiemermann: Erythropoietin attenuates cardiac dysfunction in experimental sepsis in mice via activation of the beta-common receptor. Dis Model Mech, 6(4), 1021-30 (2013)
- [223] Y. Nakazawa, T. Nishino, Y. Obata, M. Nakazawa, A. Furusu, K. Abe, M. Miyazaki, T. Koji and S. Kohno: Recombinant human erythropoietin attenuates renal tubulointerstitial injury in murine adriamycin-induced nephropathy. J Nephrol, 26(3), 527-33 (2013)
- [224] K. H. Su, S. K. Shyue, Y. R. Kou, L. C. Ching, A. N. Chiang, Y. B. Yu, C. Y. Chen, C. C. Pan and T. S. Lee: beta Common receptor integrates the erythropoietin signaling in activation of endothelial nitric oxide synthase. J Cell Physiol, 226(12), 3330-9 (2011)
- [225] H. Toba, Y. Kojima, J. Wang, K. Noda, W. Tian, M. Kobara and T. Nakata: Erythropoietin attenuated vascular dysfunction and inflammation by inhibiting NADPH oxidase-derived superoxide production in nitric oxide synthase-inhibited hypertensive rat aorta. Eur J Pharmacol, 691(1-3), 190-7 (2012)
- [226] H. Toba, N. Sawai, M. Morishita, S. Murata, M. Yoshida, K. Nakashima, Y. Morita, M. Kobara and T. Nakata: Chronic treatment with recombinant human erythropoietin exerts renoprotective effects beyond hematopoiesis in streptozotocin-induced diabetic rat. Eur J Pharmacol, 612(1-3), 106-14 (2009)
- [227] Y. C. Shang, Z. Z. Chong, S. Wang and K. Maiese: Erythropoietin and Wnt1 Govern Pathways of mTOR, Apaf-1, and XIAP in Inflammatory Microglia. Curr Neurovasc Res, 8(4), 270-285 (2011)
- [228] J. Shen, Y. Wu, J. Y. Xu, J. Zhang, S. H. Sinclair, M. Yanoff, G. Xu, W. Li and G. T. Xu: ERK-and Akt-dependent neuroprotection by erythropoietin (EPO) against glyoxal-AGEs via modulation of Bcl-xL, Bax, and BAD. Invest Ophthalmol Vis Sci, 51(1), 35-46 (2010)
- [229] G. B. Wang, Y. L. Ni, X. P. Zhou and W. F. Zhang: The AKT/mTOR pathway mediates neuronal protective effects of erythropoietin in sepsis. Mol Cell Biochem, 385(1-2), 125-32 (2014)
- [230] K. Maiese: Forkhead Transcription Factors: Vital Elements in Biology and Medicine. Advances in Experimental Medicine and Biology, Springer Science and Business Media, 665(2010)
- [231] W. H. Biggs, 3rd, W. K. Cavenee and K. C. Arden: Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse. Mamm Genome, 12(6), 416-25 (2001)
- [232] H. Huang and D. J. Tindall: Dynamic FoxO transcription factors. J Cell Sci, 120(Pt 15), 2479-87 (2007)
- [233] K. Maiese, Z. Z. Chong, Y. C. Shang and J. Hou: FoxO proteins: cunning concepts and considerations for the cardiovascular system. Clin Sci (Lond), 116(3), 191-203 (2009)
- [234] K. Maiese, Z. Z. Chong and Y. C. Shang: “Sly as a FOXO”: New paths with Forkhead signaling in the brain. Curr Neurovasc Res, 4 (4), 295-302 (2007)
- [235] D. L. Trinh, D. W. Scott, R. D. Morin, M. Mendez-Lago, J. An, S. J. Jones, A. J. Mungall, Y. Zhao, J. Schein, C. Steidl, J. M. Connors, R. D. Gascoyne and M. A. Marra: Analysis of FOXO1 mutations in diffuse large B-cell lymphoma. Blood, 121(18), 3666-74 (2013)
- [236] S. Carbajo-Pescador, J. L. Mauriz, A. Garcia-Palomo and J. Gonzalez-Gallego: FoxO proteins: regulation and molecular targets in liver cancer. Curr Med Chem, 21(10), 1231-46 (2014)
- [237] M. E. Chamorro, S. D. Wenker, D. M. Vota, D. C. Vittori and A. B. Nesse: Signaling pathways of cell proliferation are involved in the differential effect of erythropoietin and its carbamylated derivative. Biochim Biophys Acta, 1833(8), 1960-8 (2013)
- [238] P. Scodelaro Bilbao and R. Boland: Extracellular ATP regulates FoxO family of transcription factors and cell cycle progression through PI3K/Akt in MCF-7 cells. Biochim Biophys Acta, 1830(10), 4456-69 (2013)
- [239] G. Z. Tao, N. Lehwald, K. Y. Jang, J. Baek, B. Xu, M. B. Omary and K. G. Sylvester: Wnt/beta-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3. J Biol Chem, 288(24), 17214-24 (2013)
- [240] C. P. Wong, T. Kaneda, A. H. Hadi and H. Morita: Ceramicine B, a limonoid with anti-lipid droplets accumulation activity from Chisocheton ceramicus. J Nat Med, 68(1), 22-30 (2014)
- [241] H. Matsuzaki, H. Daitoku, M. Hatta, H. Aoyama, K. Yoshimochi and A. Fukamizu: Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation. Proc Natl Acad Sci U S A, 102(32), 11278-83 (2005)
- [242] G. Xu, J. Liu, K. Yoshimoto, G. Chen, T. Iwata, N. Mizusawa, Z. Duan, C. Wan and J. Jiang: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces expression of p27(kip(1)) and FoxO3a in female rat cerebral cortex and PC12 cells. Toxicol Lett, 226(3), 294-302 (2014)
- [243] Y. C. Shang, Z. Z. Chong, J. Hou and K. Maiese: Wnt1, FoxO3a, and NF-kappaB oversee microglial integrity and activation during oxidant stress. Cell Signal, 22(9), 1317-29 (2010)
- [244] A. Wilk, K. Urbanska, S. Yang, J. Y. Wang, S. Amini, L. Del Valle, F. Peruzzi, L. Meggs and K. Reiss: Insulin-like growth factor-I-forkhead box O transcription factor 3a counteracts high glucose/tumor necrosis factor-alpha-mediated neuronal damage: implications for human immunodeficiency virus encephalitis. J Neurosci Res, 89(2), 183-98 (2011)
- [245] N. Hariharan, Y. Maejima, J. Nakae, J. Paik, R. A. Depinho and J. Sadoshima: Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circ Res, 107(12), 1470-82 (2010)
- [246] S. Iyer, L. Han, S. M. Bartell, H. N. Kim, I. Gubrij, R. de Cabo, C. A. O’Brien, S. C. Manolagas and M. Almeida: Sirtuin1 (Sirt1) promotes cortical bone formation by preventing beta-catenin sequestration by FoxO transcription factors in osteoblast progenitors. J Biol Chem, 289(35), 24069-78 (2014)
- [247] J. Shi, N. Yin, L. L. Xuan, C. S. Yao, A. M. Meng and Q. Hou: Vam3, a derivative of resveratrol, attenuates cigarette smoke-induced autophagy. Acta Pharmacol Sin, 33 (7), 888-96 (2012)
- [248] Y. Akasaki, O. Alvarez-Garcia, M. Saito, B. Carames, Y. Iwamoto and M. K. Lotz: FOXO transcription factors support oxidative stress resistance in human chondrocytes. Arthritis Rheumatol, 66(12), 3349-3358 (2014)
- [249] V. Balan, G. S. Miller, L. Kaplun, K. Balan, Z. Z. Chong, F. Li, A. Kaplun, M. F. VanBerkum, R. Arking, D. C. Freeman, K. Maiese and G. Tzivion: Life span extension and neuronal cell protection by Drosophila nicotinamidase. J Biol Chem, 283(41), 27810-9 (2008)
- [250] Z. Z. Chong, S. Wang, Y. C. Shang and K. Maiese: Targeting cardiovascular disease with novel SIRT1 pathways. Future Cardiol, 8(1), 89-100 (2012)
- [251] K. Maiese, Z. Z. Chong, Y. C. Shang and S. Wang: Translating cell survival and cell longevity into treatment strategies with SIRT1. Rom J Morphol Embryol, 52(4), 1173-85 (2011)
- [252] A. F. Paraiso, K. L. Mendes and S. H. Santos: Brain activation of SIRT1: role in neuropathology. Mol Neurobiol, 48(3), 681-9 (2013)
- [253] W. Wang, C. Yan, J. Zhang, R. Lin, Q. Lin, L. Yang, F. Ren, J. Zhang, M. Ji and Y. Li: SIRT1 inhibits TNF-alpha-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1. Apoptosis, 18 (6), 689-701 (2013)
- [254] G. Arunachalam, S. M. Samuel, I. Marei, H. Ding and C. R. Triggle: Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1. Br J Pharmacol, 171(2), 523-35 (2014)
- [255] N. D’Onofrio, M. Vitiello, R. Casale, L. Servillo, A. Giovane and M. L. Balestrieri: Sirtuins in vascular diseases: Emerging roles and therapeutic potential. Biochim Biophys Acta, 1852(7), 1311-1322 (2015)
- [256] Y. Liu, H. Chen and D. Liu: Mechanistic perspectives of calorie restriction on vascular homeostasis. Sci China Life Sci, 57(8), 742-754 (2014)
- [257] S. Xu, P. Bai, P. J. Little and P. Liu: Poly(ADP-ribose) polymerase 1 (PARP1) in atherosclerosis: from molecular mechanisms to therapeutic implications. Med Res Rev, 34 (3), 644-75 (2014)
- [258] G. Favero, L. Franceschetti, L. F. Rodella and R. Rezzani: Sirtuins, aging, and cardiovascular risks. Age (Dordr), 37(4), 9804 (2015)
- [259] N. Ferrara, B. Rinaldi, G. Corbi, V. Conti, P. Stiuso, S. Boccuti, G. Rengo, F. Rossi and A. Filippelli: Exercise Training Promotes SIRT1 Activity in Aged Rats. Rejuvenation Res, 11(1), 139-150 (2008)
- [260] R. R. Alcendor, S. Gao, P. Zhai, D. Zablocki, E. Holle, X. Yu, B. Tian, T. Wagner, S. F. Vatner and J. Sadoshima: Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res, 100(10), 1512-21 (2007)
- [261] S. Xiong, G. Salazar, N. Patrushev and R. W. Alexander: FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression. J Biol Chem, 286(7), 5289-99 (2011)
- [262] E. H. Hong, S. J. Lee, J. S. Kim, K. H. Lee, H. D. Um, J. H. Kim, S. J. Kim, J. I. Kim and S. G. Hwang: Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase. J Biol Chem, 285(2), 1283-95 (2010)
- [263] Z. Gao, J. Zhang, I. Kheterpal, N. Kennedy, R. J. Davis and J. Ye: Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J Biol Chem, 286(25), 22227-34 (2011)
- [264] T. Kozako, A. Aikawa, T. Shoji, T. Fujimoto, M. Yoshimitsu, S. Shirasawa, H. Tanaka, S. Honda, H. Shimeno, N. Arima and S. Soeda: High expression of the longevity gene product SIRT1 and apoptosis induction by sirtinol in adult T-cell leukemia cells. Int J Cancer, 131(9), 2044-55 (2012)
- [265] X. F. Qi, Y. J. Li, Z. Y. Chen, S. K. Kim, K. J. Lee and D. Q. Cai: Involvement of the FoxO3a pathway in the ischemia/reperfusion injury of cardiac microvascular endothelial cells. Exp Mol Pathol, 95(2), 242-7 (2013)
- [266] Y. Yang, Y. Su, D. Wang, Y. Chen, T. Wu, G. Li, X. Sun and L. Cui: Tanshinol attenuates the deleterious effects of oxidative stress on osteoblastic differentiation via Wnt/FoxO3a signaling. Oxid Med Cell Longev, 2013, 351895 (2013)
- [267] K. Lee, Y. Hu, L. Ding, Y. Chen, Y. Takahashi, R. Mott and J. X. Ma: Therapeutic potential of a monoclonal antibody blocking the Wnt pathway in diabetic retinopathy. Diabetes, 61(11), 2948-57 (2012)
- [268] K. Maiese: WISP1: Clinical Insights for a Proliferative and Restorative Member of the CCN Family. Curr Neurovasc Res, 11(4), 378-389 (2014)
- [269] X. H. Wang, X. Sun, X. W. Meng, Z. W. Lv, Y. J. Du, Y. Zhu, J. Chen, D. X. Kong and S. Z. Jin: beta-catenin siRNA regulation of apoptosis-and angiogenesis-related gene expression in hepatocellular carcinoma cells: potential uses for gene therapy. Oncol Rep, 24(4), 1093-9 (2010)
- [270] J. Du, J. D. Klein, F. Hassounah, J. Zhang, C. Zhang and X. H. Wang: Aging increases CCN1 expression leading to muscle senescence. Am J Physiol Cell Physiol, 306(1), C28-36 (2014)
- [271] Y. Fu, H. Chang, X. Peng, Q. Bai, L. Yi, Y. Zhou, J. Zhu and M. Mi: Resveratrol inhibits breast cancer stem-like cells and induces autophagy via suppressing Wnt/beta-catenin signaling pathway. PLoS One, 9(7), e102535 (2014)
- [272] N. Shah, Y. Morsi and R. Manasseh: From mechanical stimulation to biological pathways in the regulation of stem cell fate. Cell Biochem Funct, 32(4), 309-325 (2014)
- [273] T. J. Sun, R. Tao, Y. Q. Han, G. Xu, J. Liu and Y. F. Han: Therapeutic potential of umbilical cord mesenchymal stem cells with Wnt/beta-catenin signaling pathway pre-activated for the treatment of diabetic wounds. Eur Rev Med Pharmacol Sci, 18(17), 2460-4 (2014)
- [274] A. Maeda, M. Ono, K. Holmbeck, L. Li, T. M. Kilts, V. Kram, M. L. Noonan, Y. Yoshioka, E. McNerny, M. Tantillo, D. Kohn, K. M. Lyons, P. G. Robey and M. F. Young: WNT1 induced secreted protein-1 (WISP1): A novel regulator of bone turnover and Wnt signaling. J Biol Chem (2015)
- [275] F. L’Episcopo, C. Tirolo, S. Caniglia, N. Testa, M. C. Morale, M. F. Serapide, S. Pluchino and B. Marchetti: Targeting Wnt signaling at the neuroimmune interface for dopaminergic neuroprotection/repair in Parkinson’s disease. J Mol Cell Biol, 6 (1), 13-26 (2014)
- [276] B. Marchetti and S. Pluchino: Wnt your brain be inflamed? Yes, it Wnt! Trends Mol Med, 19 (3), 144-56 (2013)
- [277] D. Ortiz-Masia, J. Cosin-Roger, S. Calatayud, C. Hernandez, R. Alos, J. Hinojosa, N. Apostolova, A. Alvarez and M. D. Barrachina: Hypoxic macrophages impair autophagy in epithelial cells through Wnt1: relevance in IBD. Mucosal Immunol, 7(4), 929-38 (2014)
- [278] D. J. Klinke, 2nd: Induction of Wnt-inducible signaling protein-1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study. PLoS Comput Biol, 10 (1), e1003409 (2014)
- [279] K. Knoblich, H. X. Wang, C. Sharma, A. L. Fletcher, S. J. Turley and M. E. Hemler: Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits beta-catenin degradation. Cell Mol Life Sci, 71(7), 1305-14 (2014)
- [280] K. Maiese, F. Li, Z. Z. Chong and Y. C. Shang: The Wnt signaling pathway: Aging gracefully as a protectionist? Pharmacol Ther, 118(1), 58-81 (2008)
- [281] H. Y. Park, K. Toume, M. A. Arai, S. K. Sadhu, F. Ahmed and M. Ishibashi: Calotropin: a cardenolide from calotropis gigantea that inhibits Wnt signaling by increasing casein kinase 1alpha in colon cancer cells. Chembiochem, 15(6), 872-8 (2014)
- [282] S. Bayod, P. Felice, P. Andres, P. Rosa, A. Camins, M. Pallas and A. M. Canudas: Downregulation of canonical Wnt signaling in hippocampus of SAMP8 mice. Neurobiol Aging (2014)
- [283] S. Bayod, I. Menella, S. Sanchez-Roige, J. F. Lalanza, R. M. Escorihuela, A. Camins, M. Pallas and A. M. Canudas: Wnt pathway regulation by long-term moderate exercise in rat hippocampus. Brain Res, 1543, 38-48 (2014)
- [284] D. C. Berwick and K. Harvey: The regulation and deregulation of Wnt signaling by PARK genes in health and disease. J Mol Cell Biol, 6(1), 3-12 (2014)
- [285] C. Gonzalez-Fernandez, C. M. Fernandez-Martos, S. Shields, E. Arenas and F. J. Rodriguez: Wnts are expressed in the spinal cord of adult mice and are differentially induced after injury. J Neurotrauma (2013)
- [286] D. Xu, W. Zhao, G. Pan, M. Qian, X. Zhu, W. Liu, G. Cai and Z. Cui: Expression of Nemo-like kinase after spinal cord injury in rats. J Mol Neurosci, 52(3), 410-8 (2014)
- [287] N. Tabatadze, C. Tomas, R. McGonigal, B. Lin, A. Schook and A. Routtenberg: Wnt transmembrane signaling and long-term spatial memory. Hippocampus, 22(6), 1228-41 (2012)
- [288] W. Loilome, P. Bungkanjana, A. Techasen, N. Namwat, P. Yongvanit, A. Puapairoj, N. Khuntikeo and G. J. Riggins: Activated macrophages promote Wnt/beta-catenin signaling in cholangiocarcinoma cells. Tumour Biol (2014)
- [289] V. Murahovschi, O. Pivovarova, I. Ilkavets, R. M. Dmitrieva, S. Docke, F. Keyhani-Nejad, O. Gogebakan, M. Osterhoff, M. Kemper, S. Hornemann, M. Markova, N. Kloting, M. Stockmann, M. O. Weickert, V. Lamounier-Zepter, P. Neuhaus, A. Konradi, S. Dooley, C. von Loeffelholz, M. Bluher, A. F. Pfeiffer and N. Rudovich: WISP1 is a novel adipokine linked to inflammation in obesity. Diabetes (2014)
- [290] S. Wang, Z. Sun, X. Zhang, Z. Li, M. Wu, W. Zhao, H. Wang, T. Chen, H. Yan and J. Zhu: Wnt1 Positively Regulates CD36 Expression via TCF4 and PPAR-gamma in Macrophages. Cell Physiol Biochem, 35(4), 1289-1302 (2015)
- [291] F. L’Episcopo, C. Tirolo, N. Testa, S. Caniglia, M. C. Morale, M. Deleidi, M. F. Serapide, S. Pluchino and B. Marchetti: Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson’s Disease Involves Cross Talk between Inflammatory and Wnt/beta-Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair. J Neurosci, 32(6), 2062-2085 (2012)
- [292] L. Wei, L. Ding, M. S. Mo, M. Lei, L. Zhang, K. Chen and P. Xu: Wnt3a protects SH-SY5Y cells against 6-hydroxydopamine toxicity by restoration of mitochondria function. Transl Neurodegener, 4, 11 (2015)
- [293] F. Pilar-Cuellar, R. Vidal, A. Diaz, E. Castro, S. dos Anjos, J. Pascual-Brazo, R. Linge, V. Vargas, H. Blanco, B. Martinez-Villayandre, A. Pazos and E. M. Valdizan: Neural plasticity and proliferation in the generation of antidepressant effects: hippocampal implication. Neural Plast, 2013, 537265 (2013)
- [294] Z. Z. Chong, Y. C. Shang, J. Hou and K. Maiese: Wnt1 neuroprotection translates into improved neurological function during oxidant stress and cerebral ischemia through AKT1 and mitochondrial apoptotic pathways. Oxid Med Cell Longev, 3(2), 153-65 (2010)
- [295] X. S. Xing, F. Liu and Z. Y. He: Akt regulates beta-catenin in a rat model of focal cerebral ischemia-reperfusion injury. Mol Med Rep (2014)
- [296] Y. Xing, X. Zhang, K. Zhao, L. Cui, L. Wang, L. Dong, Y. Li, Z. Liu, C. Wang, X. Zhang, C. Zhu, H. Qiao, Y. Ji and X. Cao: Beneficial effects of sulindac in focal cerebral ischemia: a positive role in Wnt/beta-catenin pathway. Brain Res, 1482, 71-80 (2012)
- [297] E. M. Kawamoto, M. Gleichmann, L. M. Yshii, S. Lima Lde, M. P. Mattson and C. Scavone: Effect of activation of canonical Wnt signaling by the Wnt-3a protein on the susceptibility of PC12 cells to oxidative and apoptotic insults. Braz J Med Biol Res, 45(1), 58-67 (2012)
- [298] N. Pecina-Slaus: Wnt signal transduction pathway and apoptosis: a review. Cancer Cell Int, 10, 22 (2010)
- [299] Y. Peng, B. H. Jiang, P. H. Yang, Z. Cao, X. Shi, M. C. Lin, M. L. He and H. F. Kung: Phosphatidylinositol 3-kinase signaling is involved in neurogenesis during Xenopus embryonic development. J Biol Chem, 279(27), 28509-14 (2004)
- [300] S. Wang, Z. Z. Chong, Y. C. Shang and K. Maiese: WISP1 (CCN4) autoregulates its expression and nuclear trafficking of beta-catenin during oxidant stress with limited effects upon neuronal autophagy. Curr Neurovasc Res, 9(2), 89-99 (2012)
- [301] B. Berschneider, D. C. Ellwanger, H. A. Baarsma, C. Thiel, C. Shimbori, E. S. White, M. Kolb, P. Neth and M. Konigshoff: miR-92a regulates TGF-beta1-induced WISP1 expression in pulmonary fibrosis. Int J Biochem Cell Biol, 53, 432-41 (2014)
- [302] S. Schneider, P. Kloimstein, J. Pammer, W. Brannath, M. Grasl and B. M. Erovic: New diagnostic markers in salivary gland tumors. Eur Arch Otorhinolaryngol, 271(7), 1999-2007 (2014)
- [303] M. H. van den Bosch, A. B. Blom, P. L. van Lent, H. M. van Beuningen, E. N. Blaney Davidson, P. M. van der Kraan and W. B. van den Berg: Canonical Wnt signaling skews TGF-beta signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8. Cell Signal, 26(5), 951-8 (2014)
- [304] H. Liu, J. Yin, H. Wang, G. Jiang, M. Deng, G. Zhang, X. Bu, S. Cai, J. Du and Z. He: FOXO3a modulates WNT/beta-catenin signaling and suppresses epithelial-to-mesenchymal transition in prostate cancer cells. Cell Signal, 27(3), 510-8 (2015)
- [305] M. Almeida, L. Han, M. Martin-Millan, C. A. O’Brien and S. C. Manolagas: Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor-to forkhead box O-mediated transcription. J Biol Chem, 282(37), 27298-305 (2007)
- [306] Y. Kashii, M. Uchida, K. Kirito, M. Tanaka, K. Nishijima, M. Toshima, T. Ando, K. Koizumi, T. Endoh, K. Sawada, M. Momoi, Y. Miura, K. Ozawa and N. Komatsu: Amember of Forkhead family transcription factor, FKHRL1, is one of the downstream molecules of phosphatidylinositol 3-kinase-Akt activation pathway in erythropoietin signal transduction. Blood, 96(3), 941-9. (2000)
- [307] W. J. Bakker, T. B. van Dijk, M. Parren-van Amelsvoort, A. Kolbus, K. Yamamoto, P. Steinlein, R. G. Verhaak, T. W. Mak, H. Beug, B. Lowenberg and M. von Lindern: Differential regulation of Foxo3a target genes in erythropoiesis. Mol Cell Biol, 27(10), 3839-3854 (2007)
- [308] D. Bouscary, F. Pene, Y. E. Claessens, O. Muller, S. Chretien, M. Fontenay-Roupie, S. Gisselbrecht, P. Mayeux and C. Lacombe: Critical role for PI 3-kinase in the control of erythropoietin-induced erythroid progenitor proliferation. Blood, 101(9), 3436-43 (2003)
- [309] D. L. Mahmud, G. A. M, D. K. Deb, L. C. Platanias, S. Uddin and A. Wickrema: Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells. Oncogene, 21(10), 1556-62 (2002)
- [310] Z. Z. Chong, Y. C. Shang, S. Wang and K. Maiese: PRAS40 Is an Integral Regulatory Component of Erythropoietin mTOR Signaling and Cytoprotection. PLoS ONE, 7(9), e45456 (2012)
- [311] W. J. Bakker, M. Blazquez-Domingo, A. Kolbus, J. Besooyen, P. Steinlein, H. Beug, P. J. Coffer, B. Lowenberg, M. von Lindern and T. B. van Dijk: FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. J Cell Biol, 164(2), 175-84 (2004)
- [312] K. Maiese, J. Hou, Z. Z. Chong and Y. C. Shang: Erythropoietin, forkhead proteins, and oxidative injury: biomarkers and biology. ScientificWorldJournal, 9, 1072-104 (2009)
- [313] H. Zhao, R. Wang, X. Wu, J. Liang, Z. Qi, X. Liu, L. Min, X. Ji and Y. Luo: Erythropoietin delivered via intra-arterial infusion reduces endoplasmic reticulum stress in brain microvessels of rats following cerebral ischemia and reperfusion. J Neuroimmune Pharmaco l, 10 (1), 153-61 (2015)
- [314] L. Wang, R. Teng, L. Di, H. Rogers, H. Wu, J. B. Kopp and C. T. Noguchi: PPARalpha and Sirt1 mediate erythropoietin action in increasing metabolic activity and browning of white adipocytes to protect against obesity and metabolic disorders. Diabetes, 62(12), 4122-31 (2013)
- [315] L. Wang, Y. Jia, H. Rogers, Y. P. Wu, S. Huang and C. T. Noguchi: GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1). J Biol Chem, 287(36), 30157-69 (2012)
- [316] Z. Z. Chong, Y. C. Shang and K. Maiese: Vascular injury during elevated glucose can be mitigated by erythropoietin and Wnt signaling. Curr Neurovasc Re s, 4 (3), 194-204 (2007)
- [317] L. Danielyan, R. Schafer, A. Schulz, T. Ladewig, A. Lourhmati, M. Buadze, A. L. Schmitt, S. Verleysdonk, D. Kabisch, K. Koeppen, G. Siegel, B. Proksch, T. Kluba, A. Eckert, C. Kohle, T. Schoneberg, H. Northoff, M. Schwab and C. H. Gleiter: Survival, neuron-like differentiation and functionality of mesenchymal stem cells in neurotoxic environment: the critical role of erythropoietin. Cell Death Differ, 16(12), 1599-614 (2009)
- [318] X. Chen, C. C. Wang, S. M. Song, S. Y. Wei, J. S. Li, S. L. Zhao and B. Li: The administration of erythropoietin attenuates kidney injury induced by ischemia/reperfusion with increased activation of Wnt/beta-catenin signaling. J Formos Med Assoc, 114(5), 430-7 (2015)
- [319] K. Maiese: MicroRNAs and Stem Cells to the Rescue. Curr Neurovasc Res (2015)
- [320] S. C. Johnson, M. Sangesland, M. Kaeberlein and P. S. Rabinovitch: Modulating mTOR in aging and health. Interdiscip Top Gerontol, 40, 107-27 (2015)
- [321] J. Neasta, S. Barak, S. B. Hamida and D. Ron: mTOR complex 1: a key player in neuroadaptations induced by drugs of abuse. J Neurochem, 130(2), 172-84 (2014)
- [322] C. Wang, J. T. Yu, D. Miao, Z. C. Wu, M. S. Tan and L. Tan: Targeting the mTOR Signaling Network for Alzheimer’s Disease Therapy. Mol Neurobiol, 49(1), 120-35 (2014)
- [323] Z. Z. Chong, Y. C. Shang, L. Zhang, S. Wang and K. Maiese: Mammalian target of rapamycin: hitting the bull’s -eye for neurological disorders. Oxid Med Cell Longev, 3(6), 374-91 (2010)
- [324] Z. Z. Chong and K. Maiese: Mammalian Target of Rapamycin Signaling in Diabetic Cardiovascular Disease. Cardiovasc Diabetol, 11(1), 45 (2012)
- [325] A. K. Saha, X. J. Xu, E. Lawson, R. Deoliveira, A. E. Brandon, E. W. Kraegen and N. B. Ruderman: Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. Diabetes, 59 (10), 2426-34 (2010)
- [326] P. B. Martinez de Morentin, N. Martinez-Sanchez, J. Roa, J. Ferno, R. Nogueiras, M. Tena-Sempere, C. Dieguez and M. Lopez: Hypothalamic mTOR: the rookie energy sensor. Curr Mol Med, 14(1), 3-21 (2014)
- [327] Z. Cai, B. Li, K. Li and B. Zhao: Down-regulation of amyloid-beta through AMPK activation by inhibitors of GSK-3beta in SH-SY5Y and SH-SY5Y-AbetaPP695 cells. J Alzheimers Dis, 29(1), 89-98 (2012)
- [328] H. Zhao, Z. C. Wang, K. F. Wang and X. Y. Chen: Abeta peptide secretion is reduced by Radix Polygalaeinduced autophagy via activation of the AMPK/mTOR pathway. Mol Med Rep (2015)
- [329] L. L. Du, D. M. Chai, L. N. Zhao, X. H. Li, F. C. Zhang, H. B. Zhang, L. B. Liu, K. Wu, R. Liu, J. Z. Wang and X. W. Zhou: AMPK Activation Ameliorates Alzheimer’s Disease-Like Pathology and Spatial Memory Impairment in a Streptozotocin-Induced Alzheimer’s Disease Model in Rats. J Alzheimers Dis (2014)
- [330] T. Jiang, J. T. Yu, X. C. Zhu, H. F. Wang, M. S. Tan, L. Cao, Q. Q. Zhang, L. Gao, J. Q. Shi, Y. D. Zhang and L. Tan: Acute metformin preconditioning confers neuroprotection against focal cerebral ischaemia by pre-activation of AMPK-dependent autophagy. Br J Pharmacol, 171(13), 3146-57 (2014)
- [331] N. Moroz, J. J. Carmona, E. Anderson, A. C. Hart, D. A. Sinclair and T. K. Blackwell: Dietary restriction involves NAD-dependent mechanisms and a shift toward oxidative metabolism. Aging Cell, 13 (6), 1075-1085 (2014)
- [332] E. Russo, F. Andreozzi, R. Iuliano, V. Dattilo, T. Procopio, G. Fiume, S. Mimmi, N. Perrotti, R. Citraro, G. Sesti, A. Constanti and G. De Sarro: Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release. Brain Behav Immu n, 42, 157-168 (2014)
- [333] F. Y. Guan, J. Gu, W. Li, M. Zhang, Y. Ji, J. Li, L. Chen and G. M. Hatch: Compound K protects pancreatic islet cells against apoptosis through inhibition of the AMPK/JNK pathway in type 2 diabetic mice and in MIN6 beta-cells. Life Sci, 107(1-2), 42-9 (2014)
- [334] L. Chen, B. Xu, L. Liu, Y. Luo, J. Yin, H. Zhou, W. Chen, T. Shen, X. Han and S. Huang: Hydrogen peroxide inhibits mTOR signaling by activation of AMPKalpha leading to apoptosis of neuronal cells. Lab Invest, 90 (5), 762-73 (2010)
- [335] A. Salminen, K. Kaarniranta, A. Haapasalo, H. Soininen and M. Hiltunen: AMP-activated protein kinase: a potential player in Alzheimer’s disease. J Neurochem, 118(4), 460-74 (2011)
- [336] G. Marfia, L. Madaschi, F. Marra, M. Menarini, D. Bottai, A. Formenti, C. Bellardita, A. M. Di Giulio, S. Carelli and A. Gorio: Adult neural precursors isolated from post mortem brain yield mostly neurons: an erythropoietin-dependent process. Neurobiol Dis, 43(1), 86-98 (2011)
- [337] K. P. Sanghera, N. Mathalone, R. Baigi, E. Panov, D. Wang, X. Zhao, H. Hsu, H. Wang, V. Tropepe, M. Ward and S. R. Boyd: The PI3K/Akt/mTOR pathway mediates retinal progenitor cell survival under hypoxic and superoxide stress. Mol Cell Neurosci, 47(2), 145-53 (2011)
- [338] M. G. Ryou, G. R. Choudhury, W. Li, A. Winters, F. Yuan, R. Liu and S. H. Yang: Methylene blue-induced neuronal protective mechanism against hypoxia-reoxygenation stress. Neuroscience, 301, 193-203 (2015)
- [339] L. Wang, L. Di and C. T. Noguchi: AMPK is involved in mediation of erythropoietin influence on metabolic activity and reactive oxygen species production in white adipocytes. Int J Biochem Cell Biol, 54, 1-9 (2014)
- [340] M. Andreucci, G. Fuiano, P. Presta, G. Lucisano, F. Leone, L. Fuiano, V. Bisesti, P. Esposito, D. Russo, B. Memoli, T. Faga and A. Michael: Downregulation of cell survival signalling pathways and increased cell damage in hydrogen peroxide-treated human renal proximal tubular cells by alpha-erythropoietin. Cell Prolif, 42 (4), 554-61 (2009)
- [341] X. Guo, Y. Chen, Q. Liu, J. Wu, L. Wang, X. Tang, W. Zhao and H. Zhang: Ac-cel, a novel antioxidant, protects against hydrogen peroxide-induced injury in PC12 cells via attenuation of mitochondrial dysfunction. J Mol Neurosc i, 50 (3), 453-61 (2013)
- [342] K. Maiese, Z. Z. Chong, Y. C. Shang and S. Wang: Targeting disease through novel pathways of apoptosis and autophagy. Expert Opin Ther Targets, 16(12), 1203-14 (2012)
- [343] B. Favaloro, N. Allocati, V. Graziano, C. Di Ilio and V. De Laurenzi: Role of Apoptosis in disease. Aging (Albany NY), 4(5), 330-49 (2012)
- [344] J. Folch, F. Junyent, E. Verdaguer, C. Auladell, J. G. Pizarro, C. Beas-Zarate, M. Pallas and A. Camins: Role of cell cycle re-entry in neurons: a common apoptotic mechanism of neuronal cell death. Neurotox Res, 22(3), 195-207 (2012)
- [345] A. Q. Nguyen, B. H. Cherry, G. F. Scott, M. G. Ryou and R. T. Mallet: Erythropoietin: Powerful protection of ischemic and post-ischemic brain. Exp Biol Med (Maywood) (2014)
- [346] S. Shao, Y. Yang, G. Yuan, M. Zhang and X. Yu: Signaling molecules involved in lipid-induced pancreatic Beta-cell dysfunction. Dna Cell Bio l, 32 (2), 41-9 (2013)
- [347] J. Q. Kang, Z. Z. Chong and K. Maiese: Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation. Mol Pharmacol, 64(3), 557-69 (2003)
- [348] K. Schutters and C. Reutelingsperger: Phosphatidylserine targeting for diagnosis and treatment of human diseases. Apoptosis, 15 (9), 1072-82 (2010)
- [349] G. Viola, R. Bortolozzi, E. Hamel, S. Moro, P. Brun, I. Castagliuolo, M. G. Ferlin and G. Basso: MG-2477, a new tubulin inhibitor, induces autophagy through inhibition of the Akt/mTOR pathway and delayed apoptosis in A549 cells. Biochem Pharmacol, 83(1), 16-26 (2012)
- [350] S. R. Haldar, A. Chakrabarty, S. Chowdhury, A. Haldar, S. Sengupta and M. Bhattacharyya: Oxidative Stress-Related Genes in Type 2 Diabetes: Association Analysis and Their Clinical Impact. Biochem Genet (2015)
- [351] K. Maiese, Z. Z. Chong, S. Wang and Y. C. Shang: Oxidant Stress and Signal Transduction in the Nervous System with the PI 3-K, Akt, and mTOR Cascade. Int J Mol Sc i, 13 (11), 13830-66 (2013)
- [352] H. E. Palma, P. Wolkmer, M. Gallio, M. M. Correa, R. Schmatz, G. R. Thome, L. B. Pereira, V. S. Castro, A. B. Pereira, A. Bueno, L. S. de Oliveira, D. Rosolen, T. R. Mann, B. S. de Cecco, D. L. Graca, S. T. Lopes and C. M. Mazzanti: Oxidative stress parameters in blood, liver, and kidney of diabetic rats treated with curcumin and/or insulin. Mol Cell Biochem, 386(1-2), 199-210 (2014)
- [353] C. Bowes Rickman, S. Farsiu, C. A. Toth and M. Klingeborn: Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging. Invest Ophthalmol Vis Sci, 54(14), ORSF68-80 (2013)
- [354] J. A. Miret and S. Munne-Bosch: Plant amino acid-derived vitamins: biosynthesis and function. Amino Acids, 46(4), 809-24 (2014)
- [355] Y. J. Xu, P. S. Tappia, N. S. Neki and N. S. Dhalla: Prevention of diabetes-induced cardiovascular complications upon treatment with antioxidants. Heart Fail Rev, 19(1), 113-21 (2014)
- [356] J. M. Yousef and A. M. Mohamed: Prophylactic role of B vitamins against bulk and zinc oxide nano-particles toxicity induced oxidative DNA damage and apoptosis in rat livers. Pak J Pharm Sci, 28(1), 175-84 (2015)
- [357] K. Rjiba-Touati, I. Ayed-Boussema, Y. Guedri, A. Achour, H. Bacha and S. Abid-Essefi: Effect of recombinant human erythropoietin on mitomycin C-induced oxidative stress and genotoxicity in rat kidney and heart tissues. Hum Exp Toxicol (2015)
- [358] L. Moreira, J. M. Beirao, I. Beirao and P. P. Costa: Oligomeric TTR V30M aggregates compromise cell viability, erythropoietin gene expression and promoter activity in the human hepatoma cell line Hep3B. Amyloid, 1-7 (2015)
- [359] T. Yu, L. Li, T. Chen, Z. Liu, H. Liu and Z. Li: Erythropoietin attenuates advanced glycation endproducts-induced toxicity of schwann cells in vitro. Neurochem Res, 40(4), 698-712 (2015)
- [360] X. Zhang, S. Dong, Y. Qin and X. Bian: Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms. Mol Med Rep, 11(5), 3317-29 (2015)
- [361] T. Ishii, T. Asai, T. Fukuta, D. Oyama, N. Yasuda, Y. Agato, K. Shimizu, T. Minamino and N. Oku: A single injection of liposomal asialo-erythropoietin improves motor function deficit caused by cerebral ischemia/reperfusion. Int J Pharm, 439(1-2), 269-74 (2012)
- [362] Z. Z. Chong, F. Li and K. Maiese: Erythropoietin requires NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity. Curr Neurovasc Res, 2(5), 387-99 (2005)
- [363] P. Esmaeili Tazangi, S. M. Moosavi, M. Shabani and M. Haghani: Erythropoietin improves synaptic plasticity and memory deficits by decrease of the neurotransmitter release probability in the rat model of Alzheimer’s disease. Pharmacol Biochem Behav, 130, 15-21 (2015)
- [364] S. T. Lee, K. Chu, J. E. Park, K. H. Jung, D. Jeon, J. Y. Lim, S. K. Lee, M. Kim and J. K. Roh: Erythropoietin improves memory function with reducing endothelial dysfunction and amyloid-beta burden in Alzheimer’s disease models. J Neurochem, 120(1), 115-24 (2012)
- [365] P. E. Sanchez, R. P. Fares, J. J. Risso, C. Bonnet, S. Bouvard, M. Le-Cavorsin, B. Georges, C. Moulin, A. Belmeguenai, J. Bodennec, A. Morales, J. M. Pequignot, E. E. Baulieu, R. A. Levine and L. Bezin: Optimal neuroprotection by erythropoietin requires elevated expression of its receptor in neurons. Proc Natl Acad Sci U S A, 106(24), 9848-53 (2009)
- [366] J. Soliz, J. J. Thomsen, C. Soulage, C. Lundby and M. Gassmann: Sex-dependent regulation of hypoxic ventilation in mice and humans is mediated by erythropoietin. Am J Physiol Regul Integr Comp Physiol, 296(6), R1837-46 (2009)
- [367] C. Caprara, C. Britschgi, M. Samardzija and C. Grimm: The erythropoietin receptor is not required for the development, function, and aging of rods and cells in the retinal periphery. Mol Vis, 20, 307-24 (2014)
- [368] W. Shen, S. H. Chung, M. R. Irhimeh, S. Li, S. R. Lee and M. C. Gillies: Systemic Administration of Erythropoietin Inhibits Retinopathy in RCS Rats. PLoS One, 9(8), e104759 (2014)
- [369] D. Choi, S. A. Schroer, S. Y. Lu, L. Wang, X. Wu, Y. Liu, Y. Zhang, H. Y. Gaisano, K. U. Wagner, H. Wu, R. Retnakaran and M. Woo: Erythropoietin protects against diabetes through direct effects on pancreatic beta cells. J Exp Med, 207 (13), 2831-42 (2010)
- [370] T. Yu, L. Li, Y. Bi, Z. Liu, H. Liu and Z. Li: Erythropoietin attenuates oxidative stress and apoptosis in Schwann cells isolated from streptozotocin-induced diabetic rats. J Pharm Pharmacol (2014)
- [371] Z. Z. Chong, J. Q. Kang and K. Maiese: Apaf-1, Bcl-xL, Cytochrome c, and Caspase-9 Form the Critical Elements for Cerebral Vascular Protection by Erythropoietin. J Cereb Blood Flow Metab, 23(3), 320-30 (2003)
- [372] K. R. Dimitrova and I. M. Leitman: Intramyocardial transplantation of endothelial progenitor cells and erythropoietin: a new scope for the treatment of cardiovascular disease. J Surg Res, 183 (2), 550-2 (2013)
- [373] E. Gammella, C. Leuenberger, M. Gassmann and L. Ostergaard: Evidence of synergistic/additive effects of sildenafil and erythropoietin in enhancing survival and migration of hypoxic endothelial cells. Am J Physiol Lung Cell Mol Physiol, 304(4), L230-9 (2013)
- [374] S. Hamed, D. Egozi, D. Kruchevsky, L. Teot, A. Gilhar and Y. Ullmann: Erythropoietin improves the survival of fat tissue after its transplantation in nude mice. PLoS ONE, 5(11), e13986 (2010)
- [375] S. Hamed, Y. Ullmann, D. Egozi, E. Daod, E. Hellou, M. Ashkar, A. Gilhar and L. Teot: Fibronectin potentiates topical erythropoietin-induced wound repair in diabetic mice. J Invest Dermatol, 131(6), 1365-74 (2011)
- [376] M. Kamianowska, M. Szczepanski and E. Skrzydlewska: Effects of erythropoietin on ICAM-1 and PECAM-1 expressions on human umbilical vein endothelial cells subjected to oxidative stress. Cell Biochem Funct, 29(6), 437-41 (2011)
- [377] W. S. Bond and T. S. Rex: Evidence That Erythropoietin Modulates Neuroinflammation through Differential Action on Neurons, Astrocytes, and Microglia. Front Immunol, 5, 523 (2014)
- [378] M. M. Loeliger, A. Mackintosh, R. De Matteo, R. Harding and S. M. Rees: Erythropoietin protects the developing retina in an ovine model of endotoxin-induced retinal injury. Invest Ophthalmol Vis Sci, 52(5), 2656-61 (2011)
- [379] N. Miljus, S. Heibeck, M. Jarrar, M. Micke, D. Ostrowski, H. Ehrenreich and R. Heinrich: Erythropoietin-mediated protection of insect brain neurons involves JAK and STAT but not PI3K transduction pathways. Neuroscience, 258, 218-27 (2014)
- [380] S. Pankratova, B. Gu, D. Kiryushko, I. Korshunova, L. B. Kohler, M. Rathje, E. Bock and V. Berezin: Anew agonist of the erythropoietin receptor, Epobis, induces neurite outgrowth and promotes neuronal survival. J Neurochem, 121(6), 915-23 (2012)
- [381] S. D. Wenker, M. E. Chamorro, D. C. Vittori and A. B. Nesse: Protective action of erythropoietin on neuronal damage induced by activated microglia. FEBS J, 280(7), 1630-42 (2013)
- [382] T. F. Zhou and J. G. Yu: Recombinant human erythropoietin attenuates neuronal apoptosis and cognitive defects via JAK2/STAT3 signaling in experimental endotoxemia. J Surg Res, 183 (1), 304-12 (2013)
- [383] A. Lourhmati, G. H. Buniatian, C. Paul, S. Verleysdonk, R. Buecheler, M. Buadze, B. Proksch, M. Schwab, C. H. Gleiter and L. Danielyan: Age-dependent astroglial vulnerability to hypoxia and glutamate: the role for erythropoietin. PLoS One, 8(10), e77182 (2013)
- [384] R. Schafer, L. Mueller, R. Buecheler, B. Proksch, M. Schwab, C. H. Gleiter and L. Danielyan: Interplay between Endothelin and Erythropoietin in Astroglia: The Role in Protection against Hypoxia. Int J Mol Sci, 15 (2), 2858-75 (2014)
- [385] M. Yamada, C. Burke, P. Colditz, D. W. Johnson and G. C. Gobe: Erythropoietin protects against apoptosis and increases expression of non-neuronal cell markers in the hypoxia-injured developing brain. J Pathol, 224 (1), 101-9 (2011)
- [386] N. Kaneko, E. Kako and K. Sawamoto: Enhancement of ventricular-subventricular zone-derived neurogenesis and oligodendrogenesis by erythropoietin and its derivatives. Front Cell Neurosci, 7, 235 (2013)
- [387] Y. Xu, Y. Tian, H. J. Wei, J. Chen, J. F. Dong, A. Zacharek and J. N. Zhang: Erythropoietin increases circulating endothelial progenitor cells and reduces the formation and progression of cerebral aneurysm in rats. Neuroscience, 181, 292-9 (2011)
- [388] M. H. Hussein, G. A. Daoud, H. Kakita, S. Kato, T. Goto, M. Kamei, K. Goto, M. Nobata, Y. Ozaki, T. Ito, S. Fukuda, I. Kato, S. Suzuki, H. Sobajima, F. Hara, T. Hashimoto and H. Togari: High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns. Free Radic Res, 44(4), 422-9 (2010)
- [389] K. H. Park, N. Y. Choi, S. H. Koh, H. H. Park, Y. S. Kim, M. J. Kim, S. J. Lee, H. J. Yu, K. Y. Lee, Y. J. Lee and H. T. Kim: L-DOPA neurotoxicity is prevented by neuroprotective effects of erythropoietin. Neurotoxicology, 32(6), 879-87 (2011)
- [390] Z. Y. Wang, L. J. Shen, L. Tu, D. N. Hu, G. Y. Liu, Z. L. Zhou, Y. Lin, L. H. Chen and J. Qu: Erythropoietin protects retinal pigment epithelial cells from oxidative damage. Free Radic Biol Med, 46(8), 1032-41 (2009)
- [391] J. Dang, R. Jia, Y. Tu, S. Xiao and G. Ding: Erythropoietin prevents reactive oxygen species generation and renal tubular cell apoptosis at high glucose level. Biomed Pharmacothe r, 64 (10), 681-5 (2010)
- [392] A. Francois, F. Terro, N. Quellard, B. Fernandez, D. Chassaing, T. Janet, A. Rioux-Bilan, M. Paccalin and G. Page: Impairment of autophagy in the central nervous system during lipopolysaccharide-induced inflammatory stress in mice. Mol Brain, 7(1), 56 (2014)
- [393] H. Vakifahmetoglu-Norberg, H. G. Xia and J. Yuan: Pharmacologic agents targeting autophagy. J Clin Invest, 125(1), 5-13 (2015)
- [394] C. He, H. Zhu, H. Li, M. H. Zou and Z. Xie: Dissociation of Bcl-2-Beclin1 complex by activated AMPK enhances cardiac autophagy and protects against cardiomyocyte apoptosis in diabetes. Diabetes, 62(4), 1270-81 (2013)
- [395] K. A. Kim, Y. J. Shin, M. Akram, E. S. Kim, K. W. Choi, H. Suh, C. H. Lee and O. N. Bae: High glucose condition induces autophagy in endothelial progenitor cells contributing to angiogenic impairment. Biol Pharm Bull, 37 (7), 1248-52 (2014)
- [396] Y. M. Lim, H. Lim, K. Y. Hur, W. Quan, H. Y. Lee, H. Cheon, D. Ryu, S. H. Koo, H. L. Kim, J. Kim, M. Komatsu and M. S. Lee: Systemic autophagy insufficiency compromises adaptation to metabolic stress and facilitates progression from obesity to diabetes. Nat Commun, 5, 4934 (2014)
- [397] A. Bargiela, E. Cerro-Herreros, J. M. Fernandez-Costa, J. J. Vilchez, B. Llamusi and R. Artero: Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model. Dis Model Mech, 8(7), 679-90 (2015)
- [398] W. Dong, R. Wang, L. N. Ma, B. L. Xu, J. S. Zhang, Z. W. Zhao, Y. L. Wang and X. Zhang: Influence of age-related learning and memory capacity of mice: different effects of a high and low caloric diet. Aging Clin Exp Res (2015)
- [399] I. Bendix, C. Schulze, C. Haefen, A. Gellhaus, S. Endesfelder, R. Heumann, U. Felderhoff-Mueser and M. Sifringer: Erythropoietin modulates autophagy signaling in the developing rat brain in an in vivo model of oxygen-toxicity. Int J Mol Sci, 13(10), 12939-51 (2012)
- [400] W. Jang, H. J. Kim, H. Li, K. D. Jo, M. K. Lee and H. O. Yang: The Neuroprotective Effect of Erythropoietin on Rotenone-Induced Neurotoxicity in SH-SY5Y Cells Through the Induction of Autophagy. Mol Neurobiol (2015)
- [401] R. Bierer, M. C. Peceny, C. H. Hartenberger and R. K. Ohls: Erythropoietin concentrations and neurodevelopmental outcome in preterm infants. Pediatrics, 118(3), e635-40 (2006)
- [402] R. H. Leuchter, L. Gui, A. Poncet, C. Hagmann, G. A. Lodygensky, E. Martin, B. Koller, A. Darque, H. U. Bucher and P. S. Huppi: Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age. JAMA, 312(8), 817-24 (2014)
- [403] C. S. Robertson, H. J. Hannay, J. M. Yamal, S. Gopinath, J. C. Goodman, B. C. Tilley, A. Baldwin, L. Rivera Lara, H. Saucedo-Crespo, O. Ahmed, S. Sadasivan, L. Ponce, J. Cruz-Navarro, H. Shahin, I. P. Aisiku, P. Doshi, A. Valadka, L. Neipert, J. M. Waguspack, M. L. Rubin, J. S. Benoit and P. Swank: Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial. JAMA, 312(1), 36-47 (2014)
- [404] S. C. Cramer and M. D. Hill: Human choriogonadotropin and epoetin alfa in acute ischemic stroke patients (REGENESIS-LED trial). Int J Strok e, 9 (3), 321-7 (2014)
- [405] R. Castelli, G. L. Deliliers, R. Colombo, G. Moreo, P. Gallipoli and G. Pantaleo: Biosimilar epoetin in elderly patients with low-risk myelodysplastic syndromes improves anemia, quality of life, and brain function. Ann Hematol, 93(9), 1523-9 (2014)
- [406] W. Jang, J. Park, K. J. Shin, J. S. Kim, J. S. Kim, J. Youn, J. W. Cho, E. Oh, J. Y. Ahn, K. W. Oh and H. T. Kim: Safety and efficacy of recombinant human erythropoietin treatment of non-motor symptoms in Parkinson’s disease. J Neurol Sci, 337(1-2), 47-54 (2014)
- [407] S. S. Najjar, S. V. Rao, C. Melloni, S. V. Raman, T. J. Povsic, L. Melton, G. W. Barsness, K. Prather, J. F. Heitner, R. Kilaru, L. Gruberg, V. Hasselblad, A. B. Greenbaum, M. Patel, R. J. Kim, M. Talan, L. Ferrucci, D. L. Longo, E. G. Lakatta and R. A. Harrington: Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. Jama, 305(18), 1863-72 (2011)
- [408] N. Taniguchi, T. Nakamura, T. Sawada, K. Matsubara, K. Furukawa, M. Hadase, Y. Nakahara and H. Matsubara: Erythropoietin prevention trial of coronary restenosis and cardiac remodeling after ST-elevated acute myocardial infarction (EPOC-AMI): a pilot, randomized, placebo-controlled study. Circ J, 74(11), 2365-71 (2010)
- [409] Y. Wen, J. Xu, X. Ma and Q. Gao: High-dose erythropoietin in acute ST-segment elevation myocardial infarction: a meta-analysis of randomized controlled trials. Am J Cardiovasc Drugs, 13(6), 435-42 (2013)
- [410] M. W. Bergmann, S. Haufe, F. von Knobelsdorff-Brenkenhoff, H. Mehling, R. Wassmuth, I. Munch, A. Busjahn, J. Schulz-Menger, J. Jordan, F. C. Luft and R. Dietz: Apilot study of chronic, low-dose epoetin-{beta} following percutaneous coronary intervention suggests safety, feasibility, and efficacy in patients with symptomatic ischaemic heart failure. Eur J Heart Fail, 13(5), 560-8 (2011)Cited within: 0Google Scholar
- [411] B. D. Hedley, A. L. Allan and A. Xenocostas: The role of erythropoietin and erythropoiesis-stimulating agents in tumor progression. Clin Cancer Res, 17(20), 6373-80 (2011)
- [412] K. Maiese, F. Li and Z. Z. Chong: Erythropoietin and cancer. JAMA, 293(15), 1858-1859 (2005)
- [413] C. Zhang, Z. Li, Q. Cao, C. Qin, H. Cai, H. Zhou, J. Qian, L. Tao, X. Ju and C. Yin: Association of erythropoietin gene rs576236 polymorphism and risk of adrenal tumors in a Chinese population. J Biomed Res, 28(6), 456-461 (2014)
- [414] M. Li, Q. Li, Y. H. Zhang, Z. Y. Tian, H. X. Ma, J. Zhao, S. Q. Xie and C. J. Wang: Antitumor effects and preliminary systemic toxicity of ANISpm in vivo and in vitro. Anticancer Drugs, 24(1), 32-42 (2013)
- [415] K. Maiese: Therapeutic targets for cancer: current concepts with PI 3-K, Akt, & mTOR. Indian J Med Res, 137 (2), 243-6 (2013)
- [416] R. Malla, C. R. Ashby, Jr., N. K. Narayanan, B. Narayanan, J. S. Faridi and A. K. Tiwari: Proline-rich AKT substrate of 40-kDa (PRAS40) in the pathophysiology of cancer. Biochem Biophys Res Commun (2015)
- [417] F. Barbieri, M. Albertelli, F. Grillo, A. Mohamed, A. Saveanu, A. Barlier, D. Ferone and T. Florio: Neuroendocrine tumors: insights into innovative therapeutic options and rational development of targeted therapies. Drug Discov Today, 19(4), 458-468 (2014)
- [418] V. N. Kolev, Q. G. Wright, C. M. Vidal, J. E. Ring, I. M. Shapiro, J. Ricono, D. T. Weaver, M. V. Padval, J. A. Pachter and Q. Xu: PI3K/mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells. Cancer Res, 75(2), 446-55 (2015)
- [419] K. Maiese: Neuronal Activity, Mitogens, and mTOR: Overcoming the Hurdles for the Treatment of Glioblastoma Multiforme. J Transl Sci, 1(1), 2 (2015)
- [420] Z. H. Yang, R. Zheng, Y. Gao, Q. Zhang and H. Zhang: Abnormal gene expression and gene fusion in lung adenocarcinoma with high-throughput RNA sequencing. Cancer Gene The r, 21 (2), 74-82 (2014)
- [421] B. Zhou, J. S. Damrauer, S. T. Bailey, T. Hadzic, Y. Jeong, K. Clark, C. Fan, L. Murphy, C. Y. Lee, M. A. Troester, C. R. Miller, J. Jin, D. Darr, C. M. Perou, R. L. Levine, M. Diehn and W. Y. Kim: Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal. J Clin Invest, 124 (2), 553-63 (2014)
- [422] H. Skali, H. H. Parving, P. S. Parfrey, E. A. Burdmann, E. F. Lewis, P. Ivanovich, S. R. Keithi-Reddy, J. B. McGill, J. J. McMurray, A. K. Singh, S. D. Solomon, H. Uno and M. A. Pfeffer: Stroke in patients with type 2 diabetes mellitus, chronic kidney disease, and anemia treated with Darbepoetin Alfa: the trial to reduce cardiovascular events with Aranesp therapy (TREAT) experience. Circulation, 124(25), 2903-8 (2011)
- [423] T. Frietsch, M. H. Maurer, J. Vogel, M. Gassmann, W. Kuschinsky and K. F. Waschke: Reduced cerebral blood flow but elevated cerebral glucose metabolic rate in erythropoietin overexpressing transgenic mice with excessive erythrocytosis. J Cereb Blood Flow Metab, 27(3), 469-76 (2007)
- [424] S. M. Bode-Boger, R. H. Boger, M. Kuhn, J. Radermacher and J. C. Frolich: Recombinant human erythropoietin enhances vasoconstrictor tone via endothelin-1 and constrictor prostanoids. Kidney Int, 50(4), 1255-61. (1996)
- [425] T. De Palo, M. Giordano, F. Palumbo, R. Bellantuono, G. Messina, V. Colella and A. D. Caringella: Clinical experience with darbepoietin alfa (NESP) in children undergoing hemodialysis. Pediatr Nephrol, 19(3), 337-40 (2004)
- [426] F. Semeraro, A. Cancarini, F. Morescalchi, M. R. Romano, R. dell’Omo, G. Ruggeri, L. Agnifili and C. Costagliola: Serum and intraocular concentrations of erythropoietin and vascular endothelial growth factor in patients with type 2 diabetes and proliferative retinopathy. Diabetes Metab, 40(6), 445-51 (2014)
- [427] O. O. Ogunshola, M. Moransard and M. Gassmann: Constitutive excessive erythrocytosis causes inflammation and increased vascular permeability in aged mouse brain. Brain Re s, 1531, 48-57 (2013)
- [428] Y. C. Shang, Z. Z. Chong, S. Wang and K. Maiese: WNT1 Inducible Signaling Pathway Protein 1 (WISP1) Targets PRAS40 to Govern beta-Amyloid Apoptotic Injury of Microglia. Curr Neurovasc Res, 9(4), 239-249 (2012)
- [429] N. Shahani, W. Pryor, S. Swarnkar, N. Kholodilov, G. Thinakaran, R. E. Burke and S. Subramaniam: Rheb GTPase regulates beta-secretase levels and amyloid beta generation. J Biol Chem, 289(9), 5799-808 (2014)
- [430] T. Ma, C. A. Hoeffer, E. Capetillo-Zarate, F. Yu, H. Wong, M. T. Lin, D. Tampellini, E. Klann, R. D. Blitzer and G. K. Gouras: Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer’s disease. PLoS One, 5(9) (2010)
- [431] T. Jiang, J. T. Yu, X. C. Zhu, M. S. Tan, H. F. Wang, L. Cao, Q. Q. Zhang, J. Q. Shi, L. Gao, H. Qin, Y. D. Zhang and L. Tan: Temsirolimus promotes autophagic clearance of amyloid-beta and provides protective effects in cellular and animal models of Alzheimer’s disease. Pharmacol Res, 81C, 54-63 (2014)