Role of microRNAs in hepatocellular carcinoma

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article

Lin-Na Liu¹, Dan-Dan Li¹, Hui-Xiong Xu^1,*, Shu-Guang Zheng¹, Xiao-Ping Zhang²

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¹ Department of Medical Ultrasound, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, 200072, Shanghai, China

² Department of Nuclear Medicine, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, PR China

Front. Biosci. (Landmark Ed) 2015, 20(7), 1056–1067; https://doi.org/10.2741/4358

Published: 1 June 2015

(This article belongs to the Special Issue MicroRNA in hepatic fibrosis and cirrhosis)

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Abstract

Hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of cancer related death worldwide. HCC develops through a multistep process that involves genetic and epigenetic changes. In addition to genetic and epigenetic mechanisms, recent studies have shown that microRNAs (miRNAs) play essential roles in hepatocellular carcinogenesis through the post-transcriptional regulation of tumor associated-genes. In this review, we summarize the role of miRNAs in HCC and its microenvironment, and discuss the implications for HCC therapy.

Keywords

HCC

microenvironment

miRNA

therapy

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