IMR Press / FBL / Volume 20 / Issue 7 / DOI: 10.2741/4354

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Critical role of miRNAs in pancreatic cancer
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1 Department of Interventional Radiology, Tongren Hospital, Shanghai Jiaotong University School of Medicine Shanghai 200050, PR China
2 Institute of Medical Intervention Engineering, Tongji University, North Zhongshan Road, Shanghai 200072, PR China
Academic Editor:Wei Qin
Front. Biosci. (Landmark Ed) 2015, 20(7), 1017–1028; https://doi.org/10.2741/4354
Published: 1 June 2015
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
Abstract

Pancreatic cancer (PC) is an aggressive malignancy with a high mortality rate and poor prognosis. Numerous investigations have shown that microRNA (miRNA) plays a vital role in PC. Thousands of miRNAs have been screened in PC and altered miRNAs, including circulating miRNAs, are associated with PC proliferation, apoptosis, metastasis, chemosensitivity, and radiosensitivity. Several studies have shown that miRNAs can act as potential diagnostic and prognostic markers. The present review focuses on recent advances regarding the roles of miRNAs in PC and their practical value.

Keywords
Pancreatic Cancer
miRNA
Clinical Application
Review
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