IMR Press / FBL / Volume 20 / Issue 6 / DOI: 10.2741/4348

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
The role of 14-3-3 proteins in gynecological tumors
Show Less
1 Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Wenzhou Medical University, Wenzhou 325027, China
Academic Editor:Fei He
Front. Biosci. (Landmark Ed) 2015, 20(6), 934–945; https://doi.org/10.2741/4348
Published: 1 June 2015
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
Abstract

A large family of highly conserved cellular 14-3-3 proteins plays key roles in the regulation of central physiological pathways such as metabolism, protein trafficking, signal transduction, apoptosis and regulation of cell cycle. The involvement of these proteins in the regulation of various tumor suppressor genes and oncogenes points to their potential role in human cancer. According to some, the 14-3-3 proteins in gynecological tumors, promote gynecological tumors whereas others suggest that 14-3-3 proteins function as tumor suppressors in such tumors. Here, we review the use of 14-3-3 proteins as novel markers for screening and early diagnosis of gyncyological malignancies, and in monitoring the effectiveness of treatment. 14-3-3 proteins are proposed to be used as prognostic factors and as specific target in the treatment of cancers.

Keywords
HPV
14-3-3 protein
Gynecological Tumors
Review
Share
Back to top