IMR Press / FBL / Volume 20 / Issue 6 / DOI: 10.2741/4347

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Systemic inflammation and multiple organ injury in traumatic hemorrhagic shock
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1 Emergency and Intensive Care Center, the third Xiangya Hospital of Central South University, Changsha, Hunan, China
Academic Editor:Fei He
Front. Biosci. (Landmark Ed) 2015, 20(6), 927–933;
Published: 1 June 2015
(This article belongs to the Special Issue Cellular immunology and stem cell biology)

Traumatic hemorrhagic shock (HS) is a severe outcome of traumatic injury that accounts for numerous traumatic deaths. In the process of traumatic HS, both hemorrhage and trauma can trigger a complex cascade of posttraumatic events that are related to inflammatory and immune responses, which may lead to multiple organ injury or even death. From a mechanistic perspective, systemic inflammation and organ injury are involved coagulation, the complement system, impaired microcirculation and inflammatory signaling pathways. In this review, we discuss the systemic inflammation and multiple organ injury in post-traumatic HS.

Systemic Inflammation
Multiple Organ Injury
Hemorrhagic Shock
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