IMR Press / FBL / Volume 20 / Issue 6 / DOI: 10.2741/4346

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
KIT gene mutations in gastrointestinal stromal tumor
Show Less
1 Department of General Surgery, Peking Union Medical College Hospital, CAMS and PUMC, Beijing, China
Academic Editor:Wei Qin
Front. Biosci. (Landmark Ed) 2015, 20(6), 919–926; https://doi.org/10.2741/4346
Published: 1 June 2015
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
Abstract

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. It arises in the stomach, small intestine, colon, rectum and esophagus. KIT gene mutation is a feature of GIST, in addition to PDGFRA gene mutation. KIT gene mutations have been observed to be involved in the development of GIST, its recurrence after surgery and chemotherapy resistance in GIST. Exons 13, 17, 9, and mainly exon 11 are concerned in these biological behaviors of GIST. In this review, we will discuss on the involvement of KIT gene mutations in the tumorigenesis, recurrence and chemotherapeutic resistance of GIST.

Keywords
KIT
Gene Mutation
Gastrointestinal Stromal Tumor
Review
Share
Back to top