IMR Press / FBL / Volume 20 / Issue 5 / DOI: 10.2741/4340

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Changes of cytoskeleton affect T cell biological behaviors
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1 School of Life Sciences, Northwestern Polytechnical University, 710072 Xi’an, China
2 Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, 710072 Xi’an, China
Academic Editor:Fei He
Front. Biosci. (Landmark Ed) 2015, 20(5), 829–837; https://doi.org/10.2741/4340
Published: 1 January 2015
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
Abstract

T lymphocyte (T cell) is a crucial member in adaptive immunity that protects the organism against foreign pathogens and cancer by producing cytokines and cytotoxic molecules. In T cell, the cytoskeleton is in a stable and dynamic renewed condition and maintains shape and mechanical resistance to deformation. The cytoskeleton changes lead to morphological differences of T cell, and then affect local mechanical properties and cellular behavior, including development, differentiation, polarization, migration or adhesion. In this review, we will discuss the effect of cytoskeleton changes on T cell biological behaviors and its mechanism.

Keywords
Cytoskeleton
ICAMs
LFA-1
PI3K
Review
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