Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
, Ruihua Tang 1, Jing Li 1,2, Ji Li 1,2, Yaxiong Liu 1,2, Linjie Ye 1,2, Dongyan Shao 1,2, Mingliang Jin 1,2, Qingsheng Huang 1,2, Junling Shi 1,21 School of Life Sciences, Northwestern Polytechnical University, 710072 Xi’an, China
2 Key Laboratory for Space Bioscience and Biotechnology, Northwestern Polytechnical University, 710072 Xi’an, China
Abstract
T lymphocyte (T cell) is a crucial member in adaptive immunity that protects the organism against foreign pathogens and cancer by producing cytokines and cytotoxic molecules. In T cell, the cytoskeleton is in a stable and dynamic renewed condition and maintains shape and mechanical resistance to deformation. The cytoskeleton changes lead to morphological differences of T cell, and then affect local mechanical properties and cellular behavior, including development, differentiation, polarization, migration or adhesion. In this review, we will discuss the effect of cytoskeleton changes on T cell biological behaviors and its mechanism.
Keywords
- Cytoskeleton
- ICAMs
- LFA-1
- PI3K
- Review