Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
Ciz1 promotes tumorigenicity of prostate carcinoma cells
1 Department of Urology, The First Hospital of China Medical University, Shenyang, 110001 P. R. China
2 Key Laboratory of Stem Cell Biology, Institute of Health Sciences, CAS/Shanghai Jiao Tong University School of Medicine, Shanghai 200025 China
3 Department of Rehabilitation, Guangdong General Hospital, Guangzhou 510030, P. R. China
4 Department of Urology, Hospital of Heilongjiang Province, Harbin 150036, P. R. China
5 Department of Anorectal, ShenYang Anorectal Hospital, Shenyang 110001, P. R. China
Abstract
Prostate cancer is the most common malignancy in men and is the second leading cause of cancer-related mortality in developed countries. Recent work has revealed the significance of CIP-interacting zinc finger protein 1 (CIZ1) in cancer cell biology, but its roles in prostatic carcinoma are unknown. Our study compared CIZ1 gene expression in banked prostatic carcinomas versus matched paraneoplastic tissues and in tumor cell lines of varying origin. This study revealed that the expression of
Keywords
- Ciz1
- Prostate Cancer
- Cell Cycle
- Proliferation
- Tumorigenesis
- Gene Silencing