IMR Press / FBL / Volume 20 / Issue 2 / DOI: 10.2741/4309

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Membrane lipid domains in the nervous system
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1 Department of Medical Biotechnology and Translational Medicine, University of Milan, Italy
Academic Editor:Tatsuro Mutoh
Front. Biosci. (Landmark Ed) 2015, 20(2), 280–302; https://doi.org/10.2741/4309
Published: 1 January 2015
Abstract

The structural properties of the lipids forming biological membranes determine a very high level of lateral organization within membranes. Lipid-driven membrane organization allows the segregation of membrane-associated components into membrane lipid domains, now worldwide known as lipid rafts, acting as dynamic platforms for signal transduction, protein processing and membrane turnover. Many processes necessary to the correct functions of nervous system occur in lipid rafts and are dependent on lipid raft organization. Thus, an altered lipid composition frequently occurring in neurodegenerative diseases leads to anomalous lipid raft organization and then to deregulated cell signaling.

Keywords
Lipid Rafts
Liquid-Ordered Phase
Sphingolipids
Gangliosides
Cholesterol
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