Hepatic fibrosis is caused by an imbalance

between production and dissolution of extracellular matrix

after chronic and inflmmatory injury, when hepatic stellate

cells are stimulated to proliferate and secret extracellular

matrix. The most common causes of liver fibrosis are

chronic viral hepatitis B and C. Cirrhosis is the most

advanced stage of fibrosis, which usually develop into

hepatocellular carcinoma (HCC). microRNAs participate

the pathogenesis of hepatic fibrosis and cirrhosis or even

the onset of HCC. In this review, we will summarize the

role of miRNA in the pathogenesis of viral hepatitis

fibrosis, non-alcoholic steatohepatitis fibrosis, primary

biliary cirrhosis and HCC onset, especially in the regulation

of stellate cells.