IMR Press / FBL / Volume 19 / Issue 8 / DOI: 10.2741/4292

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

MicroRNA in hepatic fibrosis and cirrhosis

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1 Department of Pathology, General Hospital of Jinan Military Command, Shandong Province, China
2 Department of Pathology, Shanghai Changzheng Hospital, Shanghai, China
3 Department of Traumatic Orthopaedics, General Hospital of Jinan Military Command, Shandong, China
Academic Editor:Wei Qin
Front. Biosci. (Landmark Ed) 2014, 19(8), 1418–1424;
Published: 1 June 2014
(This article belongs to the Special Issue MicroRNA in hepatic fibrosis and cirrhosis)

Hepatic fibrosis is caused by an imbalance between production and dissolution of extracellular matrix after chronic and inflmmatory injury, when hepatic stellate cells are stimulated to proliferate and secret extracellular matrix. The most common causes of liver fibrosis are chronic viral hepatitis B and C. Cirrhosis is the most advanced stage of fibrosis, which usually develop into hepatocellular carcinoma (HCC). microRNAs participate the pathogenesis of hepatic fibrosis and cirrhosis or even the onset of HCC. In this review, we will summarize the role of miRNA in the pathogenesis of viral hepatitis fibrosis, non-alcoholic steatohepatitis fibrosis, primary biliary cirrhosis and HCC onset, especially in the regulation of stellate cells. 

Hepatocellular Carcinoma
Hepatic Fibrosis
Stellate Cells
Hepatocellular Carcinoma
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