IMR Press / FBL / Volume 19 / Issue 8 / DOI: 10.2741/4288

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Evaluation of hepatic steatosis using dual-energy CT with MR comparison
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1 China Department of Radiology, Shanghai Ruijin Hospital, No, 197 Ruijin Er Rd, Shanghai, 200011
Front. Biosci. (Landmark Ed) 2014, 19(8), 1377–1385; https://doi.org/10.2741/4288
Published: 1 June 2014
Abstract

In this study, we aimed to explore the potential of dual-energy computed tomography (DECT) in evaluating liver fat; we also compared the diagnostic performance of DECT, T1-weighted dual-echo magnetic resonance (MR) imaging, and 1H-MR spectroscopy (1H-MRS) in assessing hepatic steatosis in a fatty liver rat model. Fat (water) concentration measurements by DECT spectral imaging, MR findings, and 1H-MRS measurements of hepatic fat showed similar correlations with the histopathologic results. Furthermore, a good correlation was observed between the fat (water) concentration and 1H-MRS measurements (r = 0.800 and P less than 0.001). The discriminant accuracies of the fat (water) concentration, MR findings, and 1H-MRS measurements were 66.7, 64, and 56 percent, respectively. Therefore, we conclude that the findings of DECT spectral CT imaging are strongly correlated with histopathologic findings in cases of steatosis; in addition, DECT can allow rapid, accurate evaluations of hepatic steatosis that are as effective as those obtained using T1-weighted dual-echo MR imaging and 1H-MRS.

Keywords
Steatosis
Dual-Energy Ct
Mrs
ChemicalShift Mr
Quantification
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