IMR Press / FBL / Volume 19 / Issue 8 / DOI: 10.2741/4287

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Deregulation of T cell response in sepsis

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1 Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, P.R. China
2 Intensive care unit, Zhejiang Provincial People’s Hospital, Hangzhou, 310014, P.R. China
Academic Editor:Fei He
Front. Biosci. (Landmark Ed) 2014, 19(8), 1370–1376; https://doi.org/10.2741/4287
Published: 1 June 2014
(This article belongs to the Special Issue Deregulation of T cell response in sepsis)
Abstract

The development of sepsis invovles the dysfunction of immunity due to an imbalance between the hyperimmune response and the immunoparalysis. Immune cells in both the innate and acquired immune system, including neutrophils, macrophages, dendritic cells, T cells and NK cells, are actively involved in the process. The interaction between immune cells, proinflammatory and anti-inflammatory cytokines contribute to the immunoparalysis in sepsis. Abnormal CD4+ and CD8+ T cell responses are major components of the deregulated acquired immune response in sepsis. Immune dysfunction of regulatory T cells (Tregs) contributes to the pathogensis of sepsis. Furthermore, IL-7 is essential for the replenishment and survival of T cells, which represents a promising target for immunotherapy of sepsis. In this review, we discusse the the immunoparalysis in the sepsis, with a focus on the deregulation of T cell response.

Keywords
T cell receptor
Toll-like receptors
Tim-3
Dendritic Cells
Review
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