IMR Press / FBL / Volume 19 / Issue 4 / DOI: 10.2741/4237

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Atopic eczema: a disease modulated by gene and environment
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1 Department of Dermatology, Shanghai Seventh People's Hospital, Shanghai, China
2 Shanghai University of Traditional Chinese Medicine, Shanghai, China
Academic Editor:Fei He
Front. Biosci. (Landmark Ed) 2014, 19(4), 707–717; https://doi.org/10.2741/4237
Published: 1 January 2014
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
Abstract

Atopic eczema (AE) is a chronic inflammatory skin disease that is mainly characterized by pruritus and epidermal barrier dysfunction. Between 15% and 20% of children and 1%-3% of adults are affected worldwide. AE is a complex disease triggered by multiple triggers, including gene and environmental factors. Impaired skin barrier function, modifications of the immune system, and hyper-reactivity to environmental stimulation directly cause and aggravate AE. In this review, we provide an overview of the recent developments and future directions in the pathogenesis of AE.

Keywords
Atopic eczema
Skin Diseases
Genetic Factors
Immune System Abnormalities
Microbes
Review
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