IMR Press / FBL / Volume 19 / Issue 4 / DOI: 10.2741/4231

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Clinical applications of coenzyme Q10
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1 Centro Andaluz de Biologia del Desarrollo (CABD), and Centro de Investigacion Biomedica en Red, Enfermedades Raras, Instituto de Salud Carlos III, Universidad Pablo de Olavide-Consejo Superior de Investigaciones Cientificas, Sevilla 41013, Spain
2 Facultad de Odontologia, Universidad de Sevilla, Sevilla 41009, Spain
Academic Editor:Valeria Tripodi
Front. Biosci. (Landmark Ed) 2014, 19(4), 619–633; https://doi.org/10.2741/4231
Published: 1 January 2014
(This article belongs to the Special Issue New clinical, technological and therapeutic study of coenzyme Q10)
Abstract

Coenzyme Q10 (CoQ10) or ubiquinone was known for its key role in mitochondrial bioenergetics as electron and proton carrier; later studies demonstrated its presence in other cellular membranes and in blood plasma, and extensively investigated its antioxidant role. These two functions constitute the basis for supporting the clinical indication of CoQ10. Furthermore, recent data indicate that CoQ10 affects expression of genes involved in human cell signalling, metabolism and transport and some of the effects of CoQ10 supplementation may be due to this property. CoQ10 deficiencies are due to autosomal recessive mutations, mitochondrial diseases, ageing-related oxidative stress and carcinogenesis processes, and also a secondary effect of statin treatment. Many neurodegenerative disorders, diabetes, cancer, fibromyalgia, muscular and cardiovascular diseases have been associated with low CoQ10 levels. CoQ10 treatment does not cause serious adverse effects in humans and new formulations have been developed that increase CoQ10 absorption and tissue distribution. Oral CoQ10 treatment is a frequent mitochondrial energizer and antioxidant strategy in many diseases that may provide a significant symptomatic benefit.

Keywords
Coenzyme Q10
clinical indications
pharmacokinetics
CoQ10-related compounds
review
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