IMR Press / FBL / Volume 19 / Issue 3 / DOI: 10.2741/4228

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Interaction of toxin-1 and T lymphocytes in toxic shock syndrome
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1 Department of emergency medicine , Affiliated Dongnan Hospital of Xiamen University School of Medicine Zhangzhou, China
2 Affiliated Dongnan Hospital of Xiamen University School of Medicine Zhangzhou, China
Academic Editor:Fei He
Front. Biosci. (Landmark Ed) 2014, 19(3), 571–577; https://doi.org/10.2741/4228
Published: 1 January 2014
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
Abstract

Toxic shock syndrome (TSS) is a potentially fatal illness caused by infection with the bacterium Staphylococcus aureus. TSS toxin-1 (TSST-1) contains a T-cell epitope with specificity for human V-beta-2. Binding of TSST-1 to the human major histocompatibility complex and T cell receptors activates T cells and triggers the secretion of high amounts of inflammatory cytokines, leading to TSS and potentially death. During this process, CD4+ T cells are inhibited by TSST-1, while regulatory T cells are increased. This suggests a protective immune response by the body in TSS. Thus, TSST-1 can trigger both, an inflammatory response that attacks the body and a protective response. In this review, we discuss the interaction between TSST-1 and T lymphocytes in TSS.

Keywords
Toxic shock syndrome; TSS toxin-1; antigen presenting cells; IFN-gamma
Review
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