Skin barrier in atopic dermatitis

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Review

Sanja Kezic^1,*, Natalija Novak², Ivone Jakasa³, Jakob M. Jungersted⁴, Michel Simon⁵, Johanna M. Brandner⁶, Maritza A. Middelkamp-Hup⁷, Stephan Weidinger⁸

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¹ Coronel Institute of Occupational Health, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands

² Department of Dermatology and Allergy, Sigmund-Freud-Str. 25, 53105 Bonn, Germany

³ Laboratory for Analytical Chemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, 10000 Zagreb, Croatia

⁴ Department of Dermatology, Roskilde Hospital, University of Copenhagen Køgevej 7-13, 4000 Roskilde, Denmark

⁵ CNRS-INSERM-University of Toulouse, UMR5165, CHU Purpan, Place du Dr. Baylac, TSA40031, 31059, Toulouse, Cedex 9, France

⁶ Department of Dermatology and Venerology, University Hospital Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany

⁷ Department of Dermatology, Academic Medical Centre, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands

⁸ Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig-Holstein, Campus Kiel, Schittenhelmstrasse 7, 24105 Kiel, Germany

Front. Biosci. (Landmark Ed) 2014, 19(3), 542–556; https://doi.org/10.2741/4225

Published: 1 January 2014

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Abstract

The skin represents the largest organ of the body and provides a vital interface between the body and the environment. Hereditary and acquired alterations of structural proteins and lipids of the stratum corneum and epidermal tight junctions leading to a diminished skin barrier function are major causative factors for a number of skin diseases, in particular atopic dermatitis (AD). This review summarizes current knowledge on the role of the skin barrier in AD with regard to pathogenesis and treatment, on the relationship between skin barrier abnormalities and immune aberrations, and on potential therapies aimed at repair of the skin barrier. Furthermore recent advances in the genetics of AD will be addressed.

Keywords

Atopic dermatitis

Skin Barrier

Genetics

Immunology

Review

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