IMR Press / FBL / Volume 18 / Issue 3 / DOI: 10.2741/4164

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Genetic susceptibility to Grave’s disease

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1 Department of Endocrinology, Long Hua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, China
Academic Editor:Fei He
Front. Biosci. (Landmark Ed) 2013, 18(3), 1080–1087; https://doi.org/10.2741/4164
Published: 1 June 2013
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
Abstract

The variety of clinical presentations of eye changes in patients with Graves’ disease (GD) suggests that complex interactions between genetic, environmental, endogenous and local factors influence the severity of Graves’ ophthalmopathy (GO). It is thought that the development of GO might be influenced by genetic factors and environmental factors, such as cigarette smoking. At present, however, the role of genetic factors in the development of GO is not known. On the basis of studies with candidate genes and other genetic approaches, several susceptibility loci in GO have been proposed, including immunological genes, human leukocyte antigen (HLA), cytotoxic T-lymphocyte antigen-4 (CTLA-4), regulatory Tcell genes and thyroid-specific genes. This review gives a brief overview of the current range of major susceptibility genes found for GD.

Keywords
Graves’ disease
Graves’ ophthalmopathy
CTLA-4
APCs
HSP70
Review
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