IMR Press / FBL / Volume 18 / Issue 3 / DOI: 10.2741/4160

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Effects of Vitamin C on health: a review of evidence

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1 Department of G.F. Ingrassia, Section of Hygiene and Public Health, University of Catania, Catania, Italy
2 Department of Drug Sciences, Section of Biochemistry, University of Catania, Catania, Italy
3 Department of Clinical Sciences and Translational Medicine, University of Rome "Tor Vergata", Rome, Italy
4 Department of Biology, Piemonte Orientale University, Alessandria, Italy
5 Department of Experimental Medicine, University of Rome “Sapienza”, Rome, Italy
6 Department of Maternal, Fetal and Neonatal Medicine, Cesare Arrigo Children's Hospital, Alessandria, Italy
7 Department of Pediatric Cardiac Surgery IRCCS, San Donato Milanese Hospital, San Donato Milanese, Italy
Academic Editor:Fabio Galvano
Front. Biosci. (Landmark Ed) 2013, 18(3), 1017–1029;
Published: 1 June 2013
(This article belongs to the Special Issue Dietary approaches to prevent chronic-degenerative diseases)

Vitamin C is an essential dietary nutrient for the biosynthesis of collagen and a co-factor in the biosynthesis of catecholamines, L-carnitine, cholesterol, amino acids, and some peptide hormones. The lack of vitamin C causes scurvy, a pathological condition leading to blood vessel fragility and connective tissue damage due to failure in producing collagen, and, finally, to death as result of a general collapse. Vitamin C is potentially involved also in cancer and cardiovascular diseases prevention. In addition, vitamin C effects on nervous system and chronically ill patients have been also documented. This review attempts to summarize recent and well established advances in vitamin C research and its clinical implications. Since vitamin C has the potential to counteract inflammation and subsequent oxidative damage that play a major role in the initiation and progression of several chronic and acute diseases, it represents a practical tool to administer for the early prevention of these pathologic conditions.

Vitamin C
Ascorbic Acid
Cardiovascular Disease
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