Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
1 Department of Orthopedics, Shaoxing People’s Hospital, Zhejiang 312000, China
2 Department of Orthopedics, The 306th Hospital of PLA, Beijing 100101, China
3 Department of Nephrology, Tongji Hospital of Tongji University, Shanghai 200065, China
4 Department of Orthopedics, Changhai Hospital of Second Military Medical University, Shanghai 200433, China
Abstract
Osteosarcoma is an aggressive sarcoma of the bone characterized by a high level of genetic instability and recurrent DNA deletions and amplifications. MicroRNAs (miRNAs) are non-coding small RNAs, usually 18–25 nucleotides in length, which repress translation and cleave mRNA by base-pairing to the 3 untranslated region of the target genes. miRNAs have demonstrated far-reaching effects on the cellular biology of development and cancer. Their role in osteosarcomagenesis remains largely unexplored. A number of reports have investigated the role of microRNAs in osteosarcoma. This review summeizes the recent research progress of miRNA in the osteosarcome.
Keywords
- miRNAs
- siRNAs
- mRNA
- Review