IMR Press / FBL / Volume 18 / Issue 2 / DOI: 10.2741/4141

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

The autoimmunity in Graves's disease

Show Less
1 Department of Endocrinology, Long Hua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, P.R. China
Academic Editor:Fei He
Front. Biosci. (Landmark Ed) 2013, 18(2), 782–787; https://doi.org/10.2741/4141
Published: 1 January 2013
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
Abstract

Graves’ disease (GD) is a systemic autoimmune syndrome manifesting complications in thyroid and orbital connective tissues. The thyroid gland plays a major role in the human body by producing the hormones necessary for appropriate energy levels and an active life. At the same time, the thyroid is highly vulnerable to autoimmune thyroid diseases. GD arises due to the complex interplay of genetic, environmental and endogenous factors, and the specific combination is required to initiate thyroid autoimmunity. Earlier studies have demonstrated the autoimmune response plays a dominant role in the development of GD. This review summarizes the inflammatory events which occur during the development of GD, such as Th17/Treg cell infiltration, Th1/Th2 cytokine and chemokine production, and the subtypes of immunogloblins (IgGs) generated.

Keywords
Graves' disease
IFN–gamma
IL-2
Review
Share
Back to top