IMR Press / FBL / Volume 18 / Issue 2 / DOI: 10.2741/4137

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

MicroRNAs in androgen-dependent PCa

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1 Department of Urology, Provincial Hospital Affiliated to Shandong University,Jinan 250021, China
2 Department of Urology, Fengxian Branch of Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai, China
3 Department of Neonatology, Fengxian Branch of Shanghai Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai, China
Academic Editor:Wei Qin
Front. Biosci. (Landmark Ed) 2013, 18(2), 748–755; https://doi.org/10.2741/4137
Published: 1 January 2013
(This article belongs to the Special Issue Pathogenesis and diagnostic modalities in cancer)
Abstract

Prostate cancer (PCa) is the most commonly diagnosed cancer among men in Western countries and is one of the leading causes of cancer deaths. The growth and progression of PCa is related to androgen levels. In cancer, nicroRNAs (miRs) function as either oncogenes or tumor suppressor genes. In androgen-dependent PCa, miRs play a role in the growth, development, progression, and metastasis of the disease, and are also involved in the response to therapy and therefore affect the prognosis. In this review, we focus on the role played by miRs concerning the mechanisms of androgen-dependent PCa.

Keywords
Prostate cancer
MicroRNAs
Single Nucleotide Polymorphisms
Review
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