IMR Press / FBL / Volume 18 / Issue 1 / DOI: 10.2741/4105

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Towards elucidating the role of SirT1 in osteoarthritis
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1 Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University of Jerusalem, P. O. Box 12272, Jerusalem 91120, Israel
2 Laboratory for Experimental Orthopaedics, Dept. of Orthopaedic Surgery, University Hospital Giessen & Marburg GmbH, Paul-Meimberg-Str. 3, D-35392 Giessen, Germany
Academic Editor:Ali Mobasheri
Front. Biosci. (Landmark Ed) 2013, 18(1), 343–355; https://doi.org/10.2741/4105
Published: 1 January 2013
(This article belongs to the Special Issue Current trends in cartilage and mesenchymal stem cell biology)
Abstract

Osteoarthritis (OA) is a degenerative joint disease particularly affecting the elderly population. Although several genetic features have been characterized as risk factors for OA susceptibility, a growing body of evidence indicates that epigenetic effectors may also modulate gene expression and thus contribute to OA pathology. One such epigenetic regulator of particular relevance to OA is Silent Information Regulator 2 type 1 (SirT1) which has been linked to aging and caloric intake, Consistently, SirT1 has been also connected with various age-associated diseases such as diabetes type II, Alzheimers and osteoporosis. Recent reports show that OA is linked to changes in SirT1 activity or levels within cartilage. In human chondrocytes, SirT1 plays a role in cartilage extracellular matrix (ECM) synthesis and promotes cell survival, even under proinflammatory stress. It appears that SirT1 fine tunes many cellular biochemical processes through its capacity to interact and modify various histone and non-histone proteins. Taken together these investigations demonstrate that SirT1 is involved in cartilage biology and could potentially serve as novel drug target in treating OA even at its premature stages, thereby possibly reversing mechanical-stress induced cartilage degeneration.

Keywords
Ageing
osteoarthritis
OA
Histone Modifying Enzymes
Silent Information Regulator 2 Type 1
Sirt1
Inflammation
Review
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