IMR Press / FBL / Volume 18 / Issue 1 / DOI: 10.2741/4101

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review

Non-syndromic thoracic aortic aneurysms and dissections-a genetic review

Show Less
1 Cardiovascular and Thoracic Surgery Department, West China Hospital of Sichuan University, Chengdu, China
Academic Editor:Xinyu Wang
Front. Biosci. (Landmark Ed) 2013, 18(1), 305–311; https://doi.org/10.2741/4101
Published: 1 January 2013
Abstract

Thoracic aortic aneurysm and dissections (TAADs) are associated with both high mortality and medical expense. Poor outcomes are preventable by surgical repair; however, identifying individuals at-risk is difficult. Researchers are scanning the human genome to characterize the genetic determinants of TAADs by identifying chromosomal regions, gene mutations, single nucleotide polymorphism (SNP), genomic copy number variants and micro-RNA variants, with the purpose of analyzing the risk of TAADs associated with these predisposing genes. The goal of this review is to develop screening tests to identify individuals at risk for non- syndromic TAADs. This genetic survey has significant clinical implications because high-risk individuals can be closely monitored and can benefit from preventative surgical repair.

Keywords
Thoracic Aortic Aneurysms
Genetic Analysis
Single Nucleotide Polymorphism
Review
Share
Back to top