IMR Press / FBL / Volume 18 / Issue 1 / DOI: 10.2741/4099

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Role of TSG101 in cancer
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1 School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China
2 Department of Pharmacology and Toxicology, The University of Texas Medical Brach, Galveston, Texas 77555-0615, USA
Academic Editor:Anna Czarnecka
Front. Biosci. (Landmark Ed) 2013, 18(1), 279–288; https://doi.org/10.2741/4099
Published: 1 January 2013
(This article belongs to the Special Issue Frontiers in molecular medicine)
Abstract

The tumor susceptibility gene 101 (TSG101) encodes a multidomain protein that contains a UEV (ubiquitin e2 variant) domain at is N-terminus and a putative DNA-binding motif at its C-terminus. In addition to being a bona fide component of the ESCRT (endosomal sorting complexes required for transport) complex 1 and playing a critical role in endosomal sorting and trafficking, TSG101 has also been implicated in an array of cellular functions including, cytokinesis, protein ubiquitination, transcriptional regulation, cell cycle and proliferation, as well as viral budding. The major focus of this article is on the role of TSG101 in tumorigenesis.

Keywords
TSG101
Cancer
Tumorigenesis
Endosomal Sorting
Ubiquitination
Cytokinesis
Cell Proliferation
Review
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