Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
The power of yeast to model diseases of the powerhouse of the cell
Matthew G. Baile 1, Steven M. Claypool 1,*
Affiliation
Article Info
1 Department of Physiology, Johns Hopkins School of Medicine, Baltimore, MD 21205-2185, USA
Abstract
Mitochondria participate in a variety of cellular functions. As such, mitochondrial diseases exhibit numerous clinical phenotypes. Because mitochondrial functions are highly conserved between humans and Saccharomyces cerevisiae, yeast are an excellent model to study mitochondrial disease, providing insight into both physiological and pathophysiological processes.
Keywords
- Mitochondria
- Oxidative Phosphorylation
- Mitochondrial Disease
- Saccharomyces cerevisiae
- Review