IMR Press / FBL / Volume 18 / Issue 1 / DOI: 10.2741/4090

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Review
Platelet-derived growth factor signaling in mesenchymal cells
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1 Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, Royal Free Campus, London, UK
2 Centre for Nephrology, Division of Medicine, UCL Medical School, Royal Free Campus, London, UK
Academic Editor:Andrew Leask
Front. Biosci. (Landmark Ed) 2013, 18(1), 106–119; https://doi.org/10.2741/4090
Published: 1 January 2013
(This article belongs to the Special Issue Signaling in tissue repair and fibrosis)
Abstract

Platelet-derived growth factors (PDGFs) and their receptors are major mitogens for many cell types of mensenchymal origin, including fibroblasts and vascular smooth muscle cells (VSMCs). Their role in enhancing migratory and proliferative responses and extracellular matrix synthesis in these cells, make them key regulators of critical biological functions and in tissue diseases including tissue remodeling, scarring and fibrosis. The activities of the PDGFs have been extensively characterized at the molecular and cellular level and in in vivo model systems. This, in turn, has lead to an increasing number of PDGF-based therapies designed to accelerate or combat defects in tissue repair. This review aims to summarize recent developments in the role of PDGF in key mesenchymal cell functions. Many of the current developments in this field have primarily focused on advancements in understanding cell differentiation, migration, proliferation and the development of emerging PDGF-based therapies and hence will be primary focus of this review.


Keywords
PDGF
PDGFR
Fibroblast
Vascular smooth muscle cell
Chondrocyte
Osteoblast
Osteoclast
Review
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