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Article
Abnormal bone metabolism in Crohn's disease
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1
Institute of Digestive Disease, Longhua Hospital,Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
2
Center of Chinese medicine therapy and systems biology, shanghai university of Traditional Chinese Medicine, Shanghai 201203, China
Front. Biosci. (Landmark Ed) 2012, 17(7), 2675–2683;
https://doi.org/10.2741/4078
Published: 1 June 2012
(This article belongs to the Special Issue Cellular immunology and stem cell biology)
Abstract
Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) have a major impact on the health of individuals and population. These diseases result from an inappropriate immune response, in genetically susceptible individuals, to microbial antigens of commensal microorganisms. This paper reviews the abnormal bone metabolism associated with CD, in order to elucidate the mechanism of bone loss.