IMR Press / FBL / Volume 17 / Issue 7 / DOI: 10.2741/4070

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on as a courtesy and upon agreement with Frontiers in Bioscience.

Open Access Article
Association between obesity and gallbladder cancer
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1 Department of Gastroenterology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
2 Storr Liver Unit, Westmead Millennium Institute, The Western Clinical School of the University of Sydney, Westmead Hospital, Westmead, NSW 2145, Australia
Academic Editor:Hua Huang
Front. Biosci. (Landmark Ed) 2012, 17(7), 2550–2558;
Published: 1 June 2012
(This article belongs to the Special Issue Regulation of type-2 immune responses)

Obesity has become a global health issue because of its increased morbidity and mortality, and a close association with at least 20 different cancers. Clinical and epidemiological studies have suggested that obesity and overweight are positively related with the risk of GBC. Gallbladder cancer (GBC) is a relatively infrequent but highly lethal neoplasm. Obesity may disturb lipid and endogenous hormones metabolism, affect gallbladder motility, increase the risk of gallstones, and thus plays a role in GBC. Control of obesity through measures such as lifestyle modification, healthy diet, and regular exercise may prove useful in the prevention of GBC.

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